The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Advances in genome-scale metabolic models of industrially important fungi
Curr Opin Biotechnol. 2023 Oct 3;84:103005. doi: 10.1016/j.copbio.2023.103005. Online ahead of print.ABSTRACTMany fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved p...
Source: Current Opinion in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Yichao Han Albert Tafur Rangel Kyle R Pomraning Eduard J Kerkhoven Joonhoon Kim Source Type: research
Advances in genome-scale metabolic models of industrially important fungi
Curr Opin Biotechnol. 2023 Oct 3;84:103005. doi: 10.1016/j.copbio.2023.103005. Online ahead of print.ABSTRACTMany fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved p...
Source: Current Opinion in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Yichao Han Albert Tafur Rangel Kyle R Pomraning Eduard J Kerkhoven Joonhoon Kim Source Type: research
Advances in genome-scale metabolic models of industrially important fungi
Curr Opin Biotechnol. 2023 Oct 3;84:103005. doi: 10.1016/j.copbio.2023.103005. Online ahead of print.ABSTRACTMany fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved p...
Source: Current Opinion in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Yichao Han Albert Tafur Rangel Kyle R Pomraning Eduard J Kerkhoven Joonhoon Kim Source Type: research
Editorial overview: Energy biotechnology as an integral solution to global challenges
Curr Opin Biotechnol. 2023 Oct 2;84:103006. doi: 10.1016/j.copbio.2023.103006. Online ahead of print.NO ABSTRACTPMID:37793238 | DOI:10.1016/j.copbio.2023.103006 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - October 4, 2023 Category: Biotechnology Authors: Junyoung O Park David R Nielsen Source Type: research
Editorial overview: Energy biotechnology as an integral solution to global challenges
Curr Opin Biotechnol. 2023 Oct 2;84:103006. doi: 10.1016/j.copbio.2023.103006. Online ahead of print.NO ABSTRACTPMID:37793238 | DOI:10.1016/j.copbio.2023.103006 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - October 4, 2023 Category: Biotechnology Authors: Junyoung O Park David R Nielsen Source Type: research
The aging tumor metabolic microenvironment
Curr Opin Biotechnol. 2023 Sep 30;84:102995. doi: 10.1016/j.copbio.2023.102995. Online ahead of print.ABSTRACTDespite the higher incidence of cancer with increasing age, few preclinical or clinical studies incorporate age. This, coupled with an aging world population, requires that we improve our understanding of how aging affects cancer development, progression, and treatment. One key area will be how the tumor microenvironment (TME) changes with age. Metabolite levels are an essential component of the TME, and they are affected by the metabolic requirements of the cells present and systemic metabolite availability. These...
Source: Current Opinion in Biotechnology - October 2, 2023 Category: Biotechnology Authors: Steven E Pilley Edgar Esparza Peter J Mullen Source Type: research
The aging tumor metabolic microenvironment
Curr Opin Biotechnol. 2023 Sep 30;84:102995. doi: 10.1016/j.copbio.2023.102995. Online ahead of print.ABSTRACTDespite the higher incidence of cancer with increasing age, few preclinical or clinical studies incorporate age. This, coupled with an aging world population, requires that we improve our understanding of how aging affects cancer development, progression, and treatment. One key area will be how the tumor microenvironment (TME) changes with age. Metabolite levels are an essential component of the TME, and they are affected by the metabolic requirements of the cells present and systemic metabolite availability. These...
Source: Current Opinion in Biotechnology - October 2, 2023 Category: Biotechnology Authors: Steven E Pilley Edgar Esparza Peter J Mullen Source Type: research
Recent advances in systems metabolic engineering
This article provides a review of the recent tools and strategies used for enzyme-, genetic module-, pathway-, flux-, genome-, and cell-level engineering, supported by illustrative examples. Furthermore, we highlight recent trends in systems metabolic engineering, which involve the application of multiple tools discussed in this review. Finally, the paper addresses the challenges and perspectives of transitioning academic-level metabolic engineering studies to commercial-scale production.PMID:37778304 | DOI:10.1016/j.copbio.2023.103004 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - October 1, 2023 Category: Biotechnology Authors: Taehee Han Alisher Nazarbekov Xuan Zou Sang Yup Lee Source Type: research
Recent advances in systems metabolic engineering
This article provides a review of the recent tools and strategies used for enzyme-, genetic module-, pathway-, flux-, genome-, and cell-level engineering, supported by illustrative examples. Furthermore, we highlight recent trends in systems metabolic engineering, which involve the application of multiple tools discussed in this review. Finally, the paper addresses the challenges and perspectives of transitioning academic-level metabolic engineering studies to commercial-scale production.PMID:37778304 | DOI:10.1016/j.copbio.2023.103004 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - October 1, 2023 Category: Biotechnology Authors: Taehee Han Alisher Nazarbekov Xuan Zou Sang Yup Lee Source Type: research
Mining natural products for advanced biofuels and sustainable bioproducts
Curr Opin Biotechnol. 2023 Sep 26;84:103003. doi: 10.1016/j.copbio.2023.103003. Online ahead of print.ABSTRACTRecently, there has been growing interest in the sustainable production of biofuels and bioproducts derived from renewable sources. Natural products, the largest and more structurally diverse group of metabolites, hold significant promise as sources for such bio-based products. However, there are two primary challenges in harnessing natural products' potential: precise mining of biosynthetic gene clusters (BGCs) that can be used as scaffolds or bioparts and their functional expression for biofuel and bioproduct man...
Source: Current Opinion in Biotechnology - September 28, 2023 Category: Biotechnology Authors: Xiaowei Li Adrian E Gadar-Lopez Ling Chen Sidharth Jayachandran Pablo Cruz-Morales Jay D Keasling Source Type: research
Mining natural products for advanced biofuels and sustainable bioproducts
Curr Opin Biotechnol. 2023 Sep 26;84:103003. doi: 10.1016/j.copbio.2023.103003. Online ahead of print.ABSTRACTRecently, there has been growing interest in the sustainable production of biofuels and bioproducts derived from renewable sources. Natural products, the largest and more structurally diverse group of metabolites, hold significant promise as sources for such bio-based products. However, there are two primary challenges in harnessing natural products' potential: precise mining of biosynthetic gene clusters (BGCs) that can be used as scaffolds or bioparts and their functional expression for biofuel and bioproduct man...
Source: Current Opinion in Biotechnology - September 28, 2023 Category: Biotechnology Authors: Xiaowei Li Adrian E Gadar-Lopez Ling Chen Sidharth Jayachandran Pablo Cruz-Morales Jay D Keasling Source Type: research
Mining natural products for advanced biofuels and sustainable bioproducts
Curr Opin Biotechnol. 2023 Sep 26;84:103003. doi: 10.1016/j.copbio.2023.103003. Online ahead of print.ABSTRACTRecently, there has been growing interest in the sustainable production of biofuels and bioproducts derived from renewable sources. Natural products, the largest and more structurally diverse group of metabolites, hold significant promise as sources for such bio-based products. However, there are two primary challenges in harnessing natural products' potential: precise mining of biosynthetic gene clusters (BGCs) that can be used as scaffolds or bioparts and their functional expression for biofuel and bioproduct man...
Source: Current Opinion in Biotechnology - September 28, 2023 Category: Biotechnology Authors: Xiaowei Li Adrian E Gadar-Lopez Ling Chen Sidharth Jayachandran Pablo Cruz-Morales Jay D Keasling Source Type: research
Tumor lipid metabolism: a mechanistic link between diet and cancer progression
Curr Opin Biotechnol. 2023 Sep 13;84:102993. doi: 10.1016/j.copbio.2023.102993. Online ahead of print.ABSTRACTThe potential for 'anti-cancer' diets to markedly alter cancer risk and prognosis has captured the imagination of patients, physicians, and researchers alike, but many of these dietary recommendations come from correlative studies that attribute certain diets to altered cancer risk. While provocative, little is known about the molecular mechanisms behind how these dietary interventions impact cancer progression. Within this context, however, changes in tumor lipid metabolism are emerging as a key contributor. In th...
Source: Current Opinion in Biotechnology - September 16, 2023 Category: Biotechnology Authors: Yu-Jin Jeong Thomas J Rogers Carolyn E Anderson Evan C Lien Source Type: research
Tumor lipid metabolism: a mechanistic link between diet and cancer progression
Curr Opin Biotechnol. 2023 Sep 13;84:102993. doi: 10.1016/j.copbio.2023.102993. Online ahead of print.ABSTRACTThe potential for 'anti-cancer' diets to markedly alter cancer risk and prognosis has captured the imagination of patients, physicians, and researchers alike, but many of these dietary recommendations come from correlative studies that attribute certain diets to altered cancer risk. While provocative, little is known about the molecular mechanisms behind how these dietary interventions impact cancer progression. Within this context, however, changes in tumor lipid metabolism are emerging as a key contributor. In th...
Source: Current Opinion in Biotechnology - September 16, 2023 Category: Biotechnology Authors: Yu-Jin Jeong Thomas J Rogers Carolyn E Anderson Evan C Lien Source Type: research
