Spatial omics techniques and data analysis for cancer immunotherapy applications
Curr Opin Biotechnol. 2024 Mar 22;87:103111. doi: 10.1016/j.copbio.2024.103111. Online ahead of print.ABSTRACTIn-depth profiling of cancer cells/tissues is expanding our understanding of the genomic, epigenomic, transcriptomic, and proteomic landscape of cancer. However, the complexity of the cancer microenvironment, particularly its immune regulation, has made it difficult to exploit the potential of cancer immunotherapy. High-throughput spatial omics technologies and analysis pipelines have emerged as powerful tools for tackling this challenge. As a result, a potential revolution in cancer diagnosis, prognosis, and treat...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Yue Zhang Ren Yuan Lee Chin Wee Tan Xue Guo Willa W-Y Yim Jeffrey Ct Lim Felicia Yt Wee W U Yang Malvika Kharbanda Jia-Ying J Lee Nye Thane Ngo Wei Qiang Leow Lit-Hsin Loo Tony Kh Lim Radoslaw M Sobota Mai Chan Lau Melissa J Davis Joe Yeong Source Type: research
Microbial synthesis of health-promoting inositols
Curr Opin Biotechnol. 2024 Mar 22;87:103114. doi: 10.1016/j.copbio.2024.103114. Online ahead of print.ABSTRACTD-chiro-inositol and scyllo-inositol are known for their health-promoting properties and promising as ingredients for functional foods. Strains of Bacillus subtilis and Corynebacterium glutamicum were created by metabolic engineering capable of inexpensive production of these two rare inositols from myo-inositol, which is the most common inositol in nature. In addition, further modifications have enabled the synthesis of the two rare inositols from the much-cheaper carbon sources, glucose or sucrose.PMID:38520822 |...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Ken-Ichi Yoshida Michael Bott Source Type: research
Editorial overview: Tumor-stroma crosstalk: Shaping and characterizing the metabolic microenvironment of tumors
Curr Opin Biotechnol. 2024 Mar 22;87:103095. doi: 10.1016/j.copbio.2024.103095. Online ahead of print.NO ABSTRACTPMID:38520823 | DOI:10.1016/j.copbio.2024.103095 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Seth Parker Thekla Cordes Source Type: research
Advancing in vivo reprogramming with synthetic biology
Curr Opin Biotechnol. 2024 Mar 22;87:103109. doi: 10.1016/j.copbio.2024.103109. Online ahead of print.ABSTRACTReprogramming cells will play a fundamental role in shaping the future of cell therapies by developing new strategies to engineer cells for improved performance and higher-order physiological functions. Approaches in synthetic biology harness cells' natural ability to sense diverse signals, integrate environmental inputs to make decisions, and execute complex behaviors based on the health of the organism or tissue. In this review, we highlight strategies in synthetic biology to reprogram cells, and discuss how rece...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Farhana Islam Mitchell R Lewis James D Craig Peyton M Leyendecker Tara L Deans Source Type: research
Spatial omics techniques and data analysis for cancer immunotherapy applications
Curr Opin Biotechnol. 2024 Mar 22;87:103111. doi: 10.1016/j.copbio.2024.103111. Online ahead of print.ABSTRACTIn-depth profiling of cancer cells/tissues is expanding our understanding of the genomic, epigenomic, transcriptomic, and proteomic landscape of cancer. However, the complexity of the cancer microenvironment, particularly its immune regulation, has made it difficult to exploit the potential of cancer immunotherapy. High-throughput spatial omics technologies and analysis pipelines have emerged as powerful tools for tackling this challenge. As a result, a potential revolution in cancer diagnosis, prognosis, and treat...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Yue Zhang Ren Yuan Lee Chin Wee Tan Xue Guo Willa W-Y Yim Jeffrey Ct Lim Felicia Yt Wee W U Yang Malvika Kharbanda Jia-Ying J Lee Nye Thane Ngo Wei Qiang Leow Lit-Hsin Loo Tony Kh Lim Radoslaw M Sobota Mai Chan Lau Melissa J Davis Joe Yeong Source Type: research
Microbial synthesis of health-promoting inositols
Curr Opin Biotechnol. 2024 Mar 22;87:103114. doi: 10.1016/j.copbio.2024.103114. Online ahead of print.ABSTRACTD-chiro-inositol and scyllo-inositol are known for their health-promoting properties and promising as ingredients for functional foods. Strains of Bacillus subtilis and Corynebacterium glutamicum were created by metabolic engineering capable of inexpensive production of these two rare inositols from myo-inositol, which is the most common inositol in nature. In addition, further modifications have enabled the synthesis of the two rare inositols from the much-cheaper carbon sources, glucose or sucrose.PMID:38520822 |...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Ken-Ichi Yoshida Michael Bott Source Type: research
Editorial overview: Tumor-stroma crosstalk: Shaping and characterizing the metabolic microenvironment of tumors
Curr Opin Biotechnol. 2024 Mar 22;87:103095. doi: 10.1016/j.copbio.2024.103095. Online ahead of print.NO ABSTRACTPMID:38520823 | DOI:10.1016/j.copbio.2024.103095 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Seth Parker Thekla Cordes Source Type: research
Advancing in vivo reprogramming with synthetic biology
Curr Opin Biotechnol. 2024 Mar 22;87:103109. doi: 10.1016/j.copbio.2024.103109. Online ahead of print.ABSTRACTReprogramming cells will play a fundamental role in shaping the future of cell therapies by developing new strategies to engineer cells for improved performance and higher-order physiological functions. Approaches in synthetic biology harness cells' natural ability to sense diverse signals, integrate environmental inputs to make decisions, and execute complex behaviors based on the health of the organism or tissue. In this review, we highlight strategies in synthetic biology to reprogram cells, and discuss how rece...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Farhana Islam Mitchell R Lewis James D Craig Peyton M Leyendecker Tara L Deans Source Type: research
Spatial omics techniques and data analysis for cancer immunotherapy applications
Curr Opin Biotechnol. 2024 Mar 22;87:103111. doi: 10.1016/j.copbio.2024.103111. Online ahead of print.ABSTRACTIn-depth profiling of cancer cells/tissues is expanding our understanding of the genomic, epigenomic, transcriptomic, and proteomic landscape of cancer. However, the complexity of the cancer microenvironment, particularly its immune regulation, has made it difficult to exploit the potential of cancer immunotherapy. High-throughput spatial omics technologies and analysis pipelines have emerged as powerful tools for tackling this challenge. As a result, a potential revolution in cancer diagnosis, prognosis, and treat...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Yue Zhang Ren Yuan Lee Chin Wee Tan Xue Guo Willa W-Y Yim Jeffrey Ct Lim Felicia Yt Wee W U Yang Malvika Kharbanda Jia-Ying J Lee Nye Thane Ngo Wei Qiang Leow Lit-Hsin Loo Tony Kh Lim Radoslaw M Sobota Mai Chan Lau Melissa J Davis Joe Yeong Source Type: research
Microbial synthesis of health-promoting inositols
Curr Opin Biotechnol. 2024 Mar 22;87:103114. doi: 10.1016/j.copbio.2024.103114. Online ahead of print.ABSTRACTD-chiro-inositol and scyllo-inositol are known for their health-promoting properties and promising as ingredients for functional foods. Strains of Bacillus subtilis and Corynebacterium glutamicum were created by metabolic engineering capable of inexpensive production of these two rare inositols from myo-inositol, which is the most common inositol in nature. In addition, further modifications have enabled the synthesis of the two rare inositols from the much-cheaper carbon sources, glucose or sucrose.PMID:38520822 |...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Ken-Ichi Yoshida Michael Bott Source Type: research
Editorial overview: Tumor-stroma crosstalk: Shaping and characterizing the metabolic microenvironment of tumors
Curr Opin Biotechnol. 2024 Mar 22;87:103095. doi: 10.1016/j.copbio.2024.103095. Online ahead of print.NO ABSTRACTPMID:38520823 | DOI:10.1016/j.copbio.2024.103095 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Seth Parker Thekla Cordes Source Type: research
Advancing in vivo reprogramming with synthetic biology
Curr Opin Biotechnol. 2024 Mar 22;87:103109. doi: 10.1016/j.copbio.2024.103109. Online ahead of print.ABSTRACTReprogramming cells will play a fundamental role in shaping the future of cell therapies by developing new strategies to engineer cells for improved performance and higher-order physiological functions. Approaches in synthetic biology harness cells' natural ability to sense diverse signals, integrate environmental inputs to make decisions, and execute complex behaviors based on the health of the organism or tissue. In this review, we highlight strategies in synthetic biology to reprogram cells, and discuss how rece...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Farhana Islam Mitchell R Lewis James D Craig Peyton M Leyendecker Tara L Deans Source Type: research
Spatial omics techniques and data analysis for cancer immunotherapy applications
Curr Opin Biotechnol. 2024 Mar 22;87:103111. doi: 10.1016/j.copbio.2024.103111. Online ahead of print.ABSTRACTIn-depth profiling of cancer cells/tissues is expanding our understanding of the genomic, epigenomic, transcriptomic, and proteomic landscape of cancer. However, the complexity of the cancer microenvironment, particularly its immune regulation, has made it difficult to exploit the potential of cancer immunotherapy. High-throughput spatial omics technologies and analysis pipelines have emerged as powerful tools for tackling this challenge. As a result, a potential revolution in cancer diagnosis, prognosis, and treat...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Yue Zhang Ren Yuan Lee Chin Wee Tan Xue Guo Willa W-Y Yim Jeffrey Ct Lim Felicia Yt Wee W U Yang Malvika Kharbanda Jia-Ying J Lee Nye Thane Ngo Wei Qiang Leow Lit-Hsin Loo Tony Kh Lim Radoslaw M Sobota Mai Chan Lau Melissa J Davis Joe Yeong Source Type: research
Microbial synthesis of health-promoting inositols
Curr Opin Biotechnol. 2024 Mar 22;87:103114. doi: 10.1016/j.copbio.2024.103114. Online ahead of print.ABSTRACTD-chiro-inositol and scyllo-inositol are known for their health-promoting properties and promising as ingredients for functional foods. Strains of Bacillus subtilis and Corynebacterium glutamicum were created by metabolic engineering capable of inexpensive production of these two rare inositols from myo-inositol, which is the most common inositol in nature. In addition, further modifications have enabled the synthesis of the two rare inositols from the much-cheaper carbon sources, glucose or sucrose.PMID:38520822 |...
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Ken-Ichi Yoshida Michael Bott Source Type: research
Editorial overview: Tumor-stroma crosstalk: Shaping and characterizing the metabolic microenvironment of tumors
Curr Opin Biotechnol. 2024 Mar 22;87:103095. doi: 10.1016/j.copbio.2024.103095. Online ahead of print.NO ABSTRACTPMID:38520823 | DOI:10.1016/j.copbio.2024.103095 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - March 23, 2024 Category: Biotechnology Authors: Seth Parker Thekla Cordes Source Type: research
