Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways
Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs...
Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research
Advances in enzymatic and organismal technologies for the recycling and upcycling of petroleum-derived plastic waste
Curr Opin Biotechnol. 2023 Nov 17;84:103021. doi: 10.1016/j.copbio.2023.103021. Online ahead of print.ABSTRACTBiological catalysts are emerging with the capability to depolymerize a wide variety of plastics. Improving and discovering these catalysts has leveraged a range of tools, including microbial ecology studies, high-throughput selections, and computationally guided mutational studies. In this review, we discuss the prospects for biological solutions to plastic recycling and upcycling with a focus on major advances in polyethylene terephthalate depolymerization, expanding the range of polymers with known biological ca...
Source: Current Opinion in Biotechnology - November 19, 2023 Category: Biotechnology Authors: Daniel J Acosta Hal S Alper Source Type: research
Advances in enzymatic and organismal technologies for the recycling and upcycling of petroleum-derived plastic waste
Curr Opin Biotechnol. 2023 Nov 17;84:103021. doi: 10.1016/j.copbio.2023.103021. Online ahead of print.ABSTRACTBiological catalysts are emerging with the capability to depolymerize a wide variety of plastics. Improving and discovering these catalysts has leveraged a range of tools, including microbial ecology studies, high-throughput selections, and computationally guided mutational studies. In this review, we discuss the prospects for biological solutions to plastic recycling and upcycling with a focus on major advances in polyethylene terephthalate depolymerization, expanding the range of polymers with known biological ca...
Source: Current Opinion in Biotechnology - November 19, 2023 Category: Biotechnology Authors: Daniel J Acosta Hal S Alper Source Type: research
Advances in enzymatic and organismal technologies for the recycling and upcycling of petroleum-derived plastic waste
Curr Opin Biotechnol. 2023 Nov 17;84:103021. doi: 10.1016/j.copbio.2023.103021. Online ahead of print.ABSTRACTBiological catalysts are emerging with the capability to depolymerize a wide variety of plastics. Improving and discovering these catalysts has leveraged a range of tools, including microbial ecology studies, high-throughput selections, and computationally guided mutational studies. In this review, we discuss the prospects for biological solutions to plastic recycling and upcycling with a focus on major advances in polyethylene terephthalate depolymerization, expanding the range of polymers with known biological ca...
Source: Current Opinion in Biotechnology - November 19, 2023 Category: Biotechnology Authors: Daniel J Acosta Hal S Alper Source Type: research
Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors
Curr Opin Biotechnol. 2023 Nov 15;84:103020. doi: 10.1016/j.copbio.2023.103020. Online ahead of print.ABSTRACTT cells engineered to express chimeric antigen receptors (CARs) have demonstrated robust response rates in treating hematological malignancies. However, solid tumors present multiple challenges that hinder the antitumor efficacy of CAR-T cells, including antigen heterogeneity, off-tumor and systemic toxicities, and the immunosuppressive milieu of the tumor microenvironment (TME). Notably, the TME of solid tumors is characterized by chemokine dysregulation and a dense architecture consisting of tumor stroma, extrace...
Source: Current Opinion in Biotechnology - November 17, 2023 Category: Biotechnology Authors: Mihe Hong Sohan Talluri Yvonne Y Chen Source Type: research
Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors
Curr Opin Biotechnol. 2023 Nov 15;84:103020. doi: 10.1016/j.copbio.2023.103020. Online ahead of print.ABSTRACTT cells engineered to express chimeric antigen receptors (CARs) have demonstrated robust response rates in treating hematological malignancies. However, solid tumors present multiple challenges that hinder the antitumor efficacy of CAR-T cells, including antigen heterogeneity, off-tumor and systemic toxicities, and the immunosuppressive milieu of the tumor microenvironment (TME). Notably, the TME of solid tumors is characterized by chemokine dysregulation and a dense architecture consisting of tumor stroma, extrace...
Source: Current Opinion in Biotechnology - November 17, 2023 Category: Biotechnology Authors: Mihe Hong Sohan Talluri Yvonne Y Chen Source Type: research
Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors
Curr Opin Biotechnol. 2023 Nov 15;84:103020. doi: 10.1016/j.copbio.2023.103020. Online ahead of print.ABSTRACTT cells engineered to express chimeric antigen receptors (CARs) have demonstrated robust response rates in treating hematological malignancies. However, solid tumors present multiple challenges that hinder the antitumor efficacy of CAR-T cells, including antigen heterogeneity, off-tumor and systemic toxicities, and the immunosuppressive milieu of the tumor microenvironment (TME). Notably, the TME of solid tumors is characterized by chemokine dysregulation and a dense architecture consisting of tumor stroma, extrace...
Source: Current Opinion in Biotechnology - November 17, 2023 Category: Biotechnology Authors: Mihe Hong Sohan Talluri Yvonne Y Chen Source Type: research
Design, construction, and application of noncanonical redox cofactor infrastructures
Curr Opin Biotechnol. 2023 Nov 6;84:103019. doi: 10.1016/j.copbio.2023.103019. Online ahead of print.ABSTRACTControlling the flow of carbon and reducing power in biological systems is a central theme in metabolic engineering. Often, trade-offs in pushing carbon flux through targeted pathways while operating in conditions agreeable to the host are required due to the central pools of the shared native redox cofactors NAD(P)/H. Noncanonical redox cofactors (NRCs) have emerged as promising tools to transform how engineers develop biotransformation systems. These new-to-Nature redox cofactors have been demonstrated to function...
Source: Current Opinion in Biotechnology - November 8, 2023 Category: Biotechnology Authors: William B Black Sean Perea Han Li Source Type: research
