Prospects of single-cell nuclear magnetic resonance spectroscopy with quantum sensors
Curr Opin Biotechnol. 2023 Aug 11;83:102975. doi: 10.1016/j.copbio.2023.102975. Online ahead of print.ABSTRACTSingle-cell analysis can unravel functional heterogeneity within cell populations otherwise obscured by ensemble measurements. However, noninvasive techniques that probe chemical entities and their dynamics are still lacking. This challenge could be overcome by novel sensors based on nitrogen-vacancy (NV) centers in diamond, which enable nuclear magnetic resonance (NMR) spectroscopy on unprecedented sample volumes. In this perspective, we briefly introduce NV-based quantum sensing and review the progress made in mi...
Source: Current Opinion in Biotechnology - August 13, 2023 Category: Biotechnology Authors: Nick R Neuling Robin D Allert Dominik B Bucher Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: Current Opinion in Biotechnology - August 13, 2023 Category: Biotechnology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research

Editorial overview: 21st Century solutions for crop improvement
Curr Opin Biotechnol. 2023 Aug 11;83:102982. doi: 10.1016/j.copbio.2023.102982. Online ahead of print.NO ABSTRACTPMID:37573626 | DOI:10.1016/j.copbio.2023.102982 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - August 13, 2023 Category: Biotechnology Authors: Jianbing Yan Alisdair R Fernie Source Type: research

Prospects of single-cell nuclear magnetic resonance spectroscopy with quantum sensors
Curr Opin Biotechnol. 2023 Aug 11;83:102975. doi: 10.1016/j.copbio.2023.102975. Online ahead of print.ABSTRACTSingle-cell analysis can unravel functional heterogeneity within cell populations otherwise obscured by ensemble measurements. However, noninvasive techniques that probe chemical entities and their dynamics are still lacking. This challenge could be overcome by novel sensors based on nitrogen-vacancy (NV) centers in diamond, which enable nuclear magnetic resonance (NMR) spectroscopy on unprecedented sample volumes. In this perspective, we briefly introduce NV-based quantum sensing and review the progress made in mi...
Source: Current Opinion in Biotechnology - August 13, 2023 Category: Biotechnology Authors: Nick R Neuling Robin D Allert Dominik B Bucher Source Type: research

Sustainable metabolic engineering requires a perfect trifecta
Curr Opin Biotechnol. 2023 Aug 11;83:102983. doi: 10.1016/j.copbio.2023.102983. Online ahead of print.ABSTRACTThe versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering ...
Source: Current Opinion in Biotechnology - August 13, 2023 Category: Biotechnology Authors: Glenn Nurwono Samantha O'Keeffe Nian Liu Junyoung O Park Source Type: research