Impact of protein coronas on nanoparticle interactions with tissues and targeted delivery
Curr Opin Biotechnol. 2023 Dec 15;85:103046. doi: 10.1016/j.copbio.2023.103046. Online ahead of print.ABSTRACTA major challenge in advancing nanoparticle (NP)-based delivery systems stems from the intricate interactions between NPs and biological systems. These interactions are largely determined by the formation of the NP-protein corona (PC), in which proteins spontaneously adsorb to the surface of NPs. The PC endows the NPs with a new biological identity, capable of altering the interactions of NPs with targeting organs and subsequent biological fate. This review discusses the mechanisms behind PC-mediated effects on tis...
Source: Current Opinion in Biotechnology - December 16, 2023 Category: Biotechnology Authors: Wei-Chun Chou Zhoumeng Lin Source Type: research
N-acetyl-aspartate metabolism at the interface of cancer, immunity, and neurodegeneration
Curr Opin Biotechnol. 2023 Dec 15;85:103051. doi: 10.1016/j.copbio.2023.103051. Online ahead of print.ABSTRACTN-acetyl-L-aspartic acid (NAA) is a prominent amino acid derivative primarily associated with vertebrate brain metabolism. This review delineates the critical role of NAA across various cell types and its significance in pathophysiological contexts, including Canavan disease and cancer metabolism. Although traditionally linked with myelination and aspartoacylase-driven carbon donation, its significance as a carbon source for myelination remains debated. Evidence suggests that intact NAA might substantially impact c...
Source: Current Opinion in Biotechnology - December 16, 2023 Category: Biotechnology Authors: Nils Krause Andre Wegner Source Type: research
Next-generation biological vector platforms for in vivo delivery of genome editing agents
Curr Opin Biotechnol. 2023 Dec 15;85:103040. doi: 10.1016/j.copbio.2023.103040. Online ahead of print.ABSTRACTCRISPR-based genome editing holds promise for addressing genetic disease, infectious disease, and cancer and has rapidly advanced from primary research to clinical trials in recent years. However, the lack of safe and potent in vivo delivery methods for CRISPR components has limited most ongoing clinical trials to ex vivo gene therapy. Effective CRISPR in vivo genome editing necessitates an effective vehicle ensuring target cell transduction while minimizing off-target effects, toxicity, and immune reactions. In th...
Source: Current Opinion in Biotechnology - December 16, 2023 Category: Biotechnology Authors: Delphine Leclerc Michael D Siroky Shannon M Miller Source Type: research
Impact of protein coronas on nanoparticle interactions with tissues and targeted delivery
Curr Opin Biotechnol. 2023 Dec 15;85:103046. doi: 10.1016/j.copbio.2023.103046. Online ahead of print.ABSTRACTA major challenge in advancing nanoparticle (NP)-based delivery systems stems from the intricate interactions between NPs and biological systems. These interactions are largely determined by the formation of the NP-protein corona (PC), in which proteins spontaneously adsorb to the surface of NPs. The PC endows the NPs with a new biological identity, capable of altering the interactions of NPs with targeting organs and subsequent biological fate. This review discusses the mechanisms behind PC-mediated effects on tis...
Source: Current Opinion in Biotechnology - December 16, 2023 Category: Biotechnology Authors: Wei-Chun Chou Zhoumeng Lin Source Type: research
N-acetyl-aspartate metabolism at the interface of cancer, immunity, and neurodegeneration
Curr Opin Biotechnol. 2023 Dec 15;85:103051. doi: 10.1016/j.copbio.2023.103051. Online ahead of print.ABSTRACTN-acetyl-L-aspartic acid (NAA) is a prominent amino acid derivative primarily associated with vertebrate brain metabolism. This review delineates the critical role of NAA across various cell types and its significance in pathophysiological contexts, including Canavan disease and cancer metabolism. Although traditionally linked with myelination and aspartoacylase-driven carbon donation, its significance as a carbon source for myelination remains debated. Evidence suggests that intact NAA might substantially impact c...
Source: Current Opinion in Biotechnology - December 16, 2023 Category: Biotechnology Authors: Nils Krause Andre Wegner Source Type: research
Engineered methane biocatalysis: strategies to assimilate methane for chemical production
Curr Opin Biotechnol. 2023 Dec 14;85:103031. doi: 10.1016/j.copbio.2023.103031. Online ahead of print.ABSTRACTMethane (CH4), one of the greenhouse gases, is considered a promising feedstock for the biological production of fuels and chemicals. Although recent studies have demonstrated the capability of methanotrophs to convert CH4 into various bioproducts by metabolic engineering, the productivity has not reached commercial levels. As such, there is a growing interest in synthetic methanotrophic systems as an alternative. This review summarizes the strategies for enhancing native CH4 assimilation and discusses the challeng...
Source: Current Opinion in Biotechnology - December 15, 2023 Category: Biotechnology Authors: Nam Kyu Kang Tin Hoang Trung Chau Eun Yeol Lee Source Type: research
Engineered methane biocatalysis: strategies to assimilate methane for chemical production
Curr Opin Biotechnol. 2023 Dec 14;85:103031. doi: 10.1016/j.copbio.2023.103031. Online ahead of print.ABSTRACTMethane (CH4), one of the greenhouse gases, is considered a promising feedstock for the biological production of fuels and chemicals. Although recent studies have demonstrated the capability of methanotrophs to convert CH4 into various bioproducts by metabolic engineering, the productivity has not reached commercial levels. As such, there is a growing interest in synthetic methanotrophic systems as an alternative. This review summarizes the strategies for enhancing native CH4 assimilation and discusses the challeng...
Source: Current Opinion in Biotechnology - December 15, 2023 Category: Biotechnology Authors: Nam Kyu Kang Tin Hoang Trung Chau Eun Yeol Lee Source Type: research
Progress and challenges in the translation of cancer nanomedicines
Curr Opin Biotechnol. 2023 Dec 13;85:103045. doi: 10.1016/j.copbio.2023.103045. Online ahead of print.ABSTRACTWith the booming development of nanotechnology, nanomedicines have made considerable progress in the pharmaceutical field. However, the number of nanodrugs approved for clinical treatment is very limited. The main obstacles stem from the complexity of nanomedicine composition, tumor heterogeneity, complexity and incomplete understanding of nanotumor interactions, uncontrollable scaling, high production costs, and uncertainty of regulations and standards. This review article described the current stage of nanomedici...
Source: Current Opinion in Biotechnology - December 14, 2023 Category: Biotechnology Authors: Fan Tong Yufan Wang Huile Gao Source Type: research
Progress and challenges in the translation of cancer nanomedicines
Curr Opin Biotechnol. 2023 Dec 13;85:103045. doi: 10.1016/j.copbio.2023.103045. Online ahead of print.ABSTRACTWith the booming development of nanotechnology, nanomedicines have made considerable progress in the pharmaceutical field. However, the number of nanodrugs approved for clinical treatment is very limited. The main obstacles stem from the complexity of nanomedicine composition, tumor heterogeneity, complexity and incomplete understanding of nanotumor interactions, uncontrollable scaling, high production costs, and uncertainty of regulations and standards. This review article described the current stage of nanomedici...
Source: Current Opinion in Biotechnology - December 14, 2023 Category: Biotechnology Authors: Fan Tong Yufan Wang Huile Gao Source Type: research
Engineering Saccharomyces cerevisiae for application in integrated bioprocessing biorefineries
Curr Opin Biotechnol. 2023 Dec 12;85:103030. doi: 10.1016/j.copbio.2023.103030. Online ahead of print.ABSTRACTAfter decades of research and development, no organism - natural or engineered - has been described that can produce commodity products through direct microbial conversion to meet industry demands in terms of rates and yields. Variation in lignocellulosic biomass (LCB) feedstocks, the lack of a widely applicable pretreatment method, and the limited economic value of energy products further complicates second-generation biofuel production. Nevertheless, the emergence of advanced genomic editing tools and a more comp...
Source: Current Opinion in Biotechnology - December 13, 2023 Category: Biotechnology Authors: Letitia S Minnaar Francois Kruger Jordan Fortuin Lazzlo J Hoffmeester Riaan den Haan Source Type: research
Applying artificial intelligence and computational modeling to nanomedicine
Curr Opin Biotechnol. 2023 Dec 12;85:103043. doi: 10.1016/j.copbio.2023.103043. Online ahead of print.ABSTRACTAchieving specific and targeted delivery of nanomedicines to diseased tissues is a major challenge. This is because the process of designing, formulating, testing, and selecting a nanoparticle delivery vehicle for a specific disease target is governed by complex multivariate interactions. Computational modeling and artificial intelligence are well-suited for analyzing and modeling large multivariate datasets in short periods of time. Computational approaches can be applied to help design nanomedicine formulations, ...
Source: Current Opinion in Biotechnology - December 13, 2023 Category: Biotechnology Authors: Sean Hamilton Benjamin R Kingston Source Type: research
Complement-dependent uptake of nanoparticles by blood phagocytes: brief overview and perspective
We describe the interplay between surface properties, complement opsonization, and immune uptake, primarily of iron oxide nanoparticles. We discuss the rigor of the published research and further identify the following knowledge gaps: 1) the role of complement in the variability of uptake of nanomaterials in healthy and diseased subjects, and 2) modulation of complement interactions to improve the performance of nanomaterials. Addressing these gaps is critical to improving translational chances of nanomaterials for drug delivery and imaging applications.PMID:38091875 | DOI:10.1016/j.copbio.2023.103044 (Source: Current Opin...
Source: Current Opinion in Biotechnology - December 13, 2023 Category: Biotechnology Authors: Yue Li Seyed Moein Moghimi Dmitri Simberg Source Type: research
Engineering Saccharomyces cerevisiae for application in integrated bioprocessing biorefineries
Curr Opin Biotechnol. 2023 Dec 12;85:103030. doi: 10.1016/j.copbio.2023.103030. Online ahead of print.ABSTRACTAfter decades of research and development, no organism - natural or engineered - has been described that can produce commodity products through direct microbial conversion to meet industry demands in terms of rates and yields. Variation in lignocellulosic biomass (LCB) feedstocks, the lack of a widely applicable pretreatment method, and the limited economic value of energy products further complicates second-generation biofuel production. Nevertheless, the emergence of advanced genomic editing tools and a more comp...
Source: Current Opinion in Biotechnology - December 13, 2023 Category: Biotechnology Authors: Letitia S Minnaar Francois Kruger Jordan Fortuin Lazzlo J Hoffmeester Riaan den Haan Source Type: research
Applying artificial intelligence and computational modeling to nanomedicine
Curr Opin Biotechnol. 2023 Dec 12;85:103043. doi: 10.1016/j.copbio.2023.103043. Online ahead of print.ABSTRACTAchieving specific and targeted delivery of nanomedicines to diseased tissues is a major challenge. This is because the process of designing, formulating, testing, and selecting a nanoparticle delivery vehicle for a specific disease target is governed by complex multivariate interactions. Computational modeling and artificial intelligence are well-suited for analyzing and modeling large multivariate datasets in short periods of time. Computational approaches can be applied to help design nanomedicine formulations, ...
Source: Current Opinion in Biotechnology - December 13, 2023 Category: Biotechnology Authors: Sean Hamilton Benjamin R Kingston Source Type: research
Complement-dependent uptake of nanoparticles by blood phagocytes: brief overview and perspective
We describe the interplay between surface properties, complement opsonization, and immune uptake, primarily of iron oxide nanoparticles. We discuss the rigor of the published research and further identify the following knowledge gaps: 1) the role of complement in the variability of uptake of nanomaterials in healthy and diseased subjects, and 2) modulation of complement interactions to improve the performance of nanomaterials. Addressing these gaps is critical to improving translational chances of nanomaterials for drug delivery and imaging applications.PMID:38091875 | DOI:10.1016/j.copbio.2023.103044 (Source: Current Opin...
Source: Current Opinion in Biotechnology - December 13, 2023 Category: Biotechnology Authors: Yue Li Seyed Moein Moghimi Dmitri Simberg Source Type: research
