The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies
Curr Opin Biotechnol. 2023 Oct 6;84:102994. doi: 10.1016/j.copbio.2023.102994. Online ahead of print.ABSTRACTModulating the immune system shows promise in treating various conditions such as autoimmune, malignant, inflammatory, and infectious diseases. While immunotherapies can provide significant clinical benefits, they can also trigger debilitating immune-related toxicities. Achieving a balance between safety and efficacy of immunotherapy remains a significant engineering challenge. Recent research has simplified the complex immune response into a sequence of coordinated signals with precise spatial and temporal arrangem...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Noor Momin Source Type: research
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies
Curr Opin Biotechnol. 2023 Oct 6;84:102994. doi: 10.1016/j.copbio.2023.102994. Online ahead of print.ABSTRACTModulating the immune system shows promise in treating various conditions such as autoimmune, malignant, inflammatory, and infectious diseases. While immunotherapies can provide significant clinical benefits, they can also trigger debilitating immune-related toxicities. Achieving a balance between safety and efficacy of immunotherapy remains a significant engineering challenge. Recent research has simplified the complex immune response into a sequence of coordinated signals with precise spatial and temporal arrangem...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Noor Momin Source Type: research
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies
Curr Opin Biotechnol. 2023 Oct 6;84:102994. doi: 10.1016/j.copbio.2023.102994. Online ahead of print.ABSTRACTModulating the immune system shows promise in treating various conditions such as autoimmune, malignant, inflammatory, and infectious diseases. While immunotherapies can provide significant clinical benefits, they can also trigger debilitating immune-related toxicities. Achieving a balance between safety and efficacy of immunotherapy remains a significant engineering challenge. Recent research has simplified the complex immune response into a sequence of coordinated signals with precise spatial and temporal arrangem...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Noor Momin Source Type: research
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Advances in genome-scale metabolic models of industrially important fungi
Curr Opin Biotechnol. 2023 Oct 3;84:103005. doi: 10.1016/j.copbio.2023.103005. Online ahead of print.ABSTRACTMany fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved p...
Source: Current Opinion in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Yichao Han Albert Tafur Rangel Kyle R Pomraning Eduard J Kerkhoven Joonhoon Kim Source Type: research
Advances in genome-scale metabolic models of industrially important fungi
Curr Opin Biotechnol. 2023 Oct 3;84:103005. doi: 10.1016/j.copbio.2023.103005. Online ahead of print.ABSTRACTMany fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved p...
Source: Current Opinion in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Yichao Han Albert Tafur Rangel Kyle R Pomraning Eduard J Kerkhoven Joonhoon Kim Source Type: research
Advances in genome-scale metabolic models of industrially important fungi
Curr Opin Biotechnol. 2023 Oct 3;84:103005. doi: 10.1016/j.copbio.2023.103005. Online ahead of print.ABSTRACTMany fungal species have been used industrially for production of biofuels and bioproducts. Developing strains with better performance in biomanufacturing contexts requires a systematic understanding of cellular metabolism. Genome-scale metabolic models (GEMs) offer a comprehensive view of interconnected pathways and a mathematical framework for downstream analysis. Recently, GEMs have been developed or updated for several industrially important fungi. Some of them incorporate enzyme constraints, enabling improved p...
Source: Current Opinion in Biotechnology - October 5, 2023 Category: Biotechnology Authors: Yichao Han Albert Tafur Rangel Kyle R Pomraning Eduard J Kerkhoven Joonhoon Kim Source Type: research
Editorial overview: Energy biotechnology as an integral solution to global challenges
Curr Opin Biotechnol. 2023 Oct 2;84:103006. doi: 10.1016/j.copbio.2023.103006. Online ahead of print.NO ABSTRACTPMID:37793238 | DOI:10.1016/j.copbio.2023.103006 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - October 4, 2023 Category: Biotechnology Authors: Junyoung O Park David R Nielsen Source Type: research
Editorial overview: Energy biotechnology as an integral solution to global challenges
Curr Opin Biotechnol. 2023 Oct 2;84:103006. doi: 10.1016/j.copbio.2023.103006. Online ahead of print.NO ABSTRACTPMID:37793238 | DOI:10.1016/j.copbio.2023.103006 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - October 4, 2023 Category: Biotechnology Authors: Junyoung O Park David R Nielsen Source Type: research
The aging tumor metabolic microenvironment
Curr Opin Biotechnol. 2023 Sep 30;84:102995. doi: 10.1016/j.copbio.2023.102995. Online ahead of print.ABSTRACTDespite the higher incidence of cancer with increasing age, few preclinical or clinical studies incorporate age. This, coupled with an aging world population, requires that we improve our understanding of how aging affects cancer development, progression, and treatment. One key area will be how the tumor microenvironment (TME) changes with age. Metabolite levels are an essential component of the TME, and they are affected by the metabolic requirements of the cells present and systemic metabolite availability. These...
Source: Current Opinion in Biotechnology - October 2, 2023 Category: Biotechnology Authors: Steven E Pilley Edgar Esparza Peter J Mullen Source Type: research
The aging tumor metabolic microenvironment
Curr Opin Biotechnol. 2023 Sep 30;84:102995. doi: 10.1016/j.copbio.2023.102995. Online ahead of print.ABSTRACTDespite the higher incidence of cancer with increasing age, few preclinical or clinical studies incorporate age. This, coupled with an aging world population, requires that we improve our understanding of how aging affects cancer development, progression, and treatment. One key area will be how the tumor microenvironment (TME) changes with age. Metabolite levels are an essential component of the TME, and they are affected by the metabolic requirements of the cells present and systemic metabolite availability. These...
Source: Current Opinion in Biotechnology - October 2, 2023 Category: Biotechnology Authors: Steven E Pilley Edgar Esparza Peter J Mullen Source Type: research
Recent advances in systems metabolic engineering
This article provides a review of the recent tools and strategies used for enzyme-, genetic module-, pathway-, flux-, genome-, and cell-level engineering, supported by illustrative examples. Furthermore, we highlight recent trends in systems metabolic engineering, which involve the application of multiple tools discussed in this review. Finally, the paper addresses the challenges and perspectives of transitioning academic-level metabolic engineering studies to commercial-scale production.PMID:37778304 | DOI:10.1016/j.copbio.2023.103004 (Source: Current Opinion in Biotechnology)
Source: Current Opinion in Biotechnology - October 1, 2023 Category: Biotechnology Authors: Taehee Han Alisher Nazarbekov Xuan Zou Sang Yup Lee Source Type: research
