Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion
Curr Opin Biotechnol. 2023 Oct 19;84:103011. doi: 10.1016/j.copbio.2023.103011. Online ahead of print.ABSTRACTProline is a nonessential amino acid, and its metabolism has been implicated in numerous malignancies. Together with a direct role in regulating cancer cells' proliferation and survival, proline metabolism plays active roles in shaping the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) display high rates of proline biosynthesis to support the production of collagen for the extracellular matrix (ECM). Indeed, impaired proline metabolism in CAFs results in reduced collagen deposition and compromis...
Source: Current Opinion in Biotechnology - October 21, 2023 Category: Biotechnology Authors: Emily J Kay Sara Zanivan Alessandro Rufini Source Type: research
Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion
Curr Opin Biotechnol. 2023 Oct 19;84:103011. doi: 10.1016/j.copbio.2023.103011. Online ahead of print.ABSTRACTProline is a nonessential amino acid, and its metabolism has been implicated in numerous malignancies. Together with a direct role in regulating cancer cells' proliferation and survival, proline metabolism plays active roles in shaping the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) display high rates of proline biosynthesis to support the production of collagen for the extracellular matrix (ECM). Indeed, impaired proline metabolism in CAFs results in reduced collagen deposition and compromis...
Source: Current Opinion in Biotechnology - October 21, 2023 Category: Biotechnology Authors: Emily J Kay Sara Zanivan Alessandro Rufini Source Type: research
O-GlcNAcylation at the center of antitumor immunity
Curr Opin Biotechnol. 2023 Oct 18;84:103009. doi: 10.1016/j.copbio.2023.103009. Online ahead of print.ABSTRACTThe post-translational modification known as O-GlcNAcylation is a highly dysregulated process in tumors, and a key contributor to malignant transformation. In contrast, after three decades since its discovery, very little has been revealed about this process in the immune system. With the prospect of targeting O-GlcNAcylation as tumor therapy, greater understanding of how it regulates immune responses in the context of the tumor microenvironment will be needed. Here, we discuss recent discoveries from which a pictu...
Source: Current Opinion in Biotechnology - October 20, 2023 Category: Biotechnology Authors: Graham A Heieis Bart Everts Source Type: research
Nucleotide metabolism in the regulation of tumor microenvironment and immune cell function
Curr Opin Biotechnol. 2023 Oct 18;84:103008. doi: 10.1016/j.copbio.2023.103008. Online ahead of print.ABSTRACTNucleotide metabolism plays a crucial role in the regulation of the tumor microenvironment (TME) and immune cell function. In the TME, limited availability of nucleotide precursors due to increased consumption by tumor cells and T cells affects both tumor development and immune function. Metabolic reprogramming in tumor cells favors pathways supporting growth and proliferation, including nucleotide synthesis. Additionally, extracellular nucleotides, such as ATP and adenosine, exhibit dual roles in modulating immune...
Source: Current Opinion in Biotechnology - October 20, 2023 Category: Biotechnology Authors: Helena B Madsen Marlies Jw Peeters Per Thor Straten Claus Desler Source Type: research
Interactions between nanoparticle corona proteins and the immune system
Curr Opin Biotechnol. 2023 Oct 16;84:103010. doi: 10.1016/j.copbio.2023.103010. Online ahead of print.ABSTRACTThe corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can interact with the immune system. This review article describes the impact of these interactions on nanomedicine stability, biodistribution, efficacy, and safety. Notably, it highlights the latest findings on the generation of antibody responses to the polyethylene glycol (PEG) component of SARS-CoV-2 mRNA vaccines and possible mechanisms of hypersensitivity reactions induced by ant...
Source: Current Opinion in Biotechnology - October 18, 2023 Category: Biotechnology Authors: Trieu Tm Tran Steve R Roffler Source Type: research
Interactions between nanoparticle corona proteins and the immune system
Curr Opin Biotechnol. 2023 Oct 16;84:103010. doi: 10.1016/j.copbio.2023.103010. Online ahead of print.ABSTRACTThe corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can interact with the immune system. This review article describes the impact of these interactions on nanomedicine stability, biodistribution, efficacy, and safety. Notably, it highlights the latest findings on the generation of antibody responses to the polyethylene glycol (PEG) component of SARS-CoV-2 mRNA vaccines and possible mechanisms of hypersensitivity reactions induced by ant...
Source: Current Opinion in Biotechnology - October 18, 2023 Category: Biotechnology Authors: Trieu Tm Tran Steve R Roffler Source Type: research
Interactions between nanoparticle corona proteins and the immune system
Curr Opin Biotechnol. 2023 Oct 16;84:103010. doi: 10.1016/j.copbio.2023.103010. Online ahead of print.ABSTRACTThe corona surrounding nanoparticles (NPs) in serum contains proteins such as complement, immunoglobulins, and apolipoproteins that can interact with the immune system. This review article describes the impact of these interactions on nanomedicine stability, biodistribution, efficacy, and safety. Notably, it highlights the latest findings on the generation of antibody responses to the polyethylene glycol (PEG) component of SARS-CoV-2 mRNA vaccines and possible mechanisms of hypersensitivity reactions induced by ant...
Source: Current Opinion in Biotechnology - October 18, 2023 Category: Biotechnology Authors: Trieu Tm Tran Steve R Roffler Source Type: research
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies
Curr Opin Biotechnol. 2023 Oct 6;84:102994. doi: 10.1016/j.copbio.2023.102994. Online ahead of print.ABSTRACTModulating the immune system shows promise in treating various conditions such as autoimmune, malignant, inflammatory, and infectious diseases. While immunotherapies can provide significant clinical benefits, they can also trigger debilitating immune-related toxicities. Achieving a balance between safety and efficacy of immunotherapy remains a significant engineering challenge. Recent research has simplified the complex immune response into a sequence of coordinated signals with precise spatial and temporal arrangem...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Noor Momin Source Type: research
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies
Curr Opin Biotechnol. 2023 Oct 6;84:102994. doi: 10.1016/j.copbio.2023.102994. Online ahead of print.ABSTRACTModulating the immune system shows promise in treating various conditions such as autoimmune, malignant, inflammatory, and infectious diseases. While immunotherapies can provide significant clinical benefits, they can also trigger debilitating immune-related toxicities. Achieving a balance between safety and efficacy of immunotherapy remains a significant engineering challenge. Recent research has simplified the complex immune response into a sequence of coordinated signals with precise spatial and temporal arrangem...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Noor Momin Source Type: research
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies
Curr Opin Biotechnol. 2023 Oct 6;84:102994. doi: 10.1016/j.copbio.2023.102994. Online ahead of print.ABSTRACTModulating the immune system shows promise in treating various conditions such as autoimmune, malignant, inflammatory, and infectious diseases. While immunotherapies can provide significant clinical benefits, they can also trigger debilitating immune-related toxicities. Achieving a balance between safety and efficacy of immunotherapy remains a significant engineering challenge. Recent research has simplified the complex immune response into a sequence of coordinated signals with precise spatial and temporal arrangem...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Noor Momin Source Type: research
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies
Curr Opin Biotechnol. 2023 Oct 6;84:102994. doi: 10.1016/j.copbio.2023.102994. Online ahead of print.ABSTRACTModulating the immune system shows promise in treating various conditions such as autoimmune, malignant, inflammatory, and infectious diseases. While immunotherapies can provide significant clinical benefits, they can also trigger debilitating immune-related toxicities. Achieving a balance between safety and efficacy of immunotherapy remains a significant engineering challenge. Recent research has simplified the complex immune response into a sequence of coordinated signals with precise spatial and temporal arrangem...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Noor Momin Source Type: research
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment
Curr Opin Biotechnol. 2023 Oct 6;84:102996. doi: 10.1016/j.copbio.2023.102996. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) consists of a network of metabolically interconnected tumor and immune cell types. Macrophages influence the metabolic composition within the TME, which directly impacts the metabolic state and drug response of tumors. The accumulation of oncometabolites, such as succinate, fumarate, and 2-hydroxyglutarate, represents metabolic vulnerabilities in cancer that can be targeted therapeutically. Immunometabolites are emerging as metabolic regulators of the TME impacting immune cell functi...
Source: Current Opinion in Biotechnology - October 8, 2023 Category: Biotechnology Authors: Fangfang Chen Birte Dowerg Thekla Cordes Source Type: research
