The aging tumor metabolic microenvironment

Curr Opin Biotechnol. 2023 Sep 30;84:102995. doi: 10.1016/j.copbio.2023.102995. Online ahead of print.ABSTRACTDespite the higher incidence of cancer with increasing age, few preclinical or clinical studies incorporate age. This, coupled with an aging world population, requires that we improve our understanding of how aging affects cancer development, progression, and treatment. One key area will be how the tumor microenvironment (TME) changes with age. Metabolite levels are an essential component of the TME, and they are affected by the metabolic requirements of the cells present and systemic metabolite availability. These factors are affected by aging, causing different TME metabolic states between young and older adults. In this review, we will summarize what is known about how aging impacts the TME metabolic state, and suggest how we can improve our understanding of it.PMID:37783168 | DOI:10.1016/j.copbio.2023.102995
Source: Current Opinion in Biotechnology - Category: Biotechnology Authors: Source Type: research