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Docking of T6361 Analogues as Potential Inhibitors of E.coli MurA Followed by ADME-Toxicity Study
CONCLUSION: We propose two analogues of T6361 as new potential inhibitors of MurA enzyme. Their good ADME-Toxicity profile qualifies them to reach in vitro and in vivo assays as future lead molecules.PMID:37929742 | DOI:10.2174/0115701638244582231025110143 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 6, 2023 Category: Drugs & Pharmacology Authors: Ilham Boulhissa Hanane Boucherit Abdelouahab Chikhi Abderrahmane Bensegueni Source Type: research

A Review on the Role of Phytoconstituents Chrysin on the Protective Effect on Liver and Kidney
CONCLUSION: According to this revised study, chrysin is a promising phytoconstituent that can be utilized as an alternate treatment for various medications that cause hepatotoxicity and nephrotoxicity. With active chrysin, several dosage forms targeting the liver and kidneys can be formulated.PMID:37921185 | DOI:10.2174/0115701638242317231018144944 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 3, 2023 Category: Drugs & Pharmacology Authors: Debika Sarmah Rupa Sengupta Source Type: research

Design, In Silico Molecular Docking, and ADMET Prediction of Amide Derivatives of Chalcone Nucleus as EGFR Inhibitors for the Treatment of Cancer
CONCLUSION: Molecules AC9 and AC19 showed good docking scores and a promising ADMET profile. In the future, these derivatives can be further evaluated for wet lab studies and determination of their biological activity.PMID:37921215 | DOI:10.2174/0115701638263890231027071518 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - November 3, 2023 Category: Drugs & Pharmacology Authors: Shital M Patil Vrushali Randive Indrani Mahadik Kalyani Asgaonkar Source Type: research

Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research