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A Snapshot of Biomarkers in Psoriasis
Curr Drug Discov Technol. 2024 Mar 18. doi: 10.2174/0115701638278470240312075112. Online ahead of print.ABSTRACTA persistent long-standing, inflammatory skin condition that is brought on by a variety of factors is psoriasis. It is distinguished by itchy, scaly, reddish plaques, particularly on areas of the body that are frequently chafed, including the extensor sites of the limbs. Recent developments in molecular-targeted therapy that use biologics or small-molecule inhibitors can effectively cure even the worst psoriatic indications. The outstanding clinical outcomes of treatment help to clarify the disease's detrimental ...
Source: Current Drug Discovery Technologies - March 19, 2024 Category: Drugs & Pharmacology Authors: Krushna Abhale Addepalli Veeranjaneyulu Shivani Desai Source Type: research

Synthesis, Molecular Docking, and Biological Evaluation of Novel Indole--triazole Conjugates
CONCLUSION: In summary, our research underscores the efficacy of molecular hybridization in shaping the physicochemical, pharmacokinetic, and biological characteristics of novel indole-triazole derivatives.PMID:38482620 | DOI:10.2174/0115701638295739240222074426 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 14, 2024 Category: Drugs & Pharmacology Authors: Paras Berwal Suman Rohilla Nancy Mathur Ketki Rani Source Type: research

A Combination of Pharmacophore Generation, Ligand-based Virtual Screening, Atom-based 3D-QSAR, and Molecular Docking Studies on Febuxostat-based Amides Analogues as Anti-inflammatory Agents
CONCLUSION: The virtual screen compounds have shown similar docking interaction with amino acid residues as shown by standard diclofenac sodium drugs. Therefore, the findings in the present study can be explored in the development of potent anti-inflammatory agents.PMID:38485685 | DOI:10.2174/0115701638281229240226101906 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 14, 2024 Category: Drugs & Pharmacology Authors: Trupti Chitre Aniket Bhatambrekar Purvaj Hirode Shubhangi Thorat Sayli G Hajare Dinesh Garud Sakshi Jagdale Kalyani Asgaonkar Source Type: research

Effects of Mesenchymal Stem Cell-conditioned Media with Natural Immunomodulatory Agent Resveratrol on Type 1 Diabetes
CONCLUSION: In the current investigation, we concluded that CM and CM+ Resveratrol, as natural immunomodulators, have the capacity to regenerate injured pancreatic beta cells and have antidiabetic action, together with immunomodulating impact. Nonetheless, future studies on this therapy appear to be promising.PMID:38468534 | DOI:10.2174/0115701638276524240305054259 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 12, 2024 Category: Drugs & Pharmacology Authors: Krushna Abhale Addepalli Veeranjaneyulu Shivani Desai Avinash Sanap Ramesh Bhonde Source Type: research

In Silico Evaluation of NO-Sartans against SARS-CoV-2
CONCLUSION: Based on our in silico studies, CLC-1280 (a Valsartan dinitrate) has the potential to be considered as an inhibitor of the SARS-CoV-2 virus. However, further in vitro and in vivo evaluations are necessary for the drug development process.PMID:38445698 | DOI:10.2174/0115701638279362240223070810 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 6, 2024 Category: Drugs & Pharmacology Authors: Negar Omidkhah Farzin Hadizadeh Razieh Ghodsi Prashant Kesharwani Amirhossein Sahebkar Source Type: research