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Effects of Kojic Acid-mediated Sonodynamic Therapy as a Matrix Metalloprotease-9 Inhibitor against Oral Squamous Cell Carcinoma: A Bioinformatics Screening and in vitro Analysis
CONCLUSIONS: Overall, Kojic acid-mediated SDT as an MMP-9 inhibitor can be a promising adjuvant treatment for OSCC. The study highlights the potential of in silico approaches to evaluate therapeutic methods for cancer treatment.PMID:38073102 | DOI:10.2174/0115701638266082231124055825 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - December 11, 2023 Category: Drugs & Pharmacology Authors: Maryam Pourhajibagher Mojgan Alaeddini Shahroo Etemad-Moghadam Steven Parker Abbas Bahador Source Type: research

In Search of Novel SGLT2 Inhibitors by High-throughput Virtual Screening
CONCLUSION: The identified molecules could manage T2DM effectively by inhibiting SGLT2, providing a promising avenue for future therapeutic strategies.PMID:38047361 | DOI:10.2174/0115701638267615231123160650 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - December 4, 2023 Category: Drugs & Pharmacology Authors: Abhijit Debnath Shalini Sharma Rupa Mazumder Avijit Mazumder Rajesh Kumar Ankit Kumar Arpita Dua Priya Singhal Arvind Kumar Gurvinder Singh Source Type: research

Artificial Intelligence for the Management of Breast Cancer: An Overview
Curr Drug Discov Technol. 2023 Dec 1. doi: 10.2174/0115701638262066231030052520. Online ahead of print.ABSTRACTBreast cancer is a severe global health problem, and early detection, accurate diagnosis, and personalized treatment is the key to improving patient outcomes. Artificial intelligence (AI) and machine learning (ML) have emerged as promising breast cancer research and clinical practice tools in recent years. Various projects are underway in early detection, diagnosis, prognosis, drug discovery, advanced image analysis, precision medicine, predictive modeling, and personalized treatment planning using artificial inte...
Source: Current Drug Discovery Technologies - December 4, 2023 Category: Drugs & Pharmacology Authors: Kapil Kumar Harshita Gandhi Source Type: research