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Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF- α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats
CONCLUSION: The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.PMID:37870057 | DOI:10.2174/0115701638252203230919092315 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 23, 2023 Category: Drugs & Pharmacology Authors: None Shivam Asheesh Kumar Gupta Source Type: research

Design, Docking, Characterisation, and Synthesis of Pyrimidine Derivatives for Antidepressant Activity
CONCLUSION: Compound 24 showed the highest MolDock score as well as found to be the most potent antidepressant agent.PMID:37859311 | DOI:10.2174/0115701638243835230925161546 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: Ashwini Jadhav Sunil G Shingade Prachita Gauns Dessai Bheemanagouda S Biradar Shivalingrao MamleDesai Source Type: research

In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets
CONCLUSION: The present in silico screening study suggested that active phytomolecules from medicinal plants could inhibit SARS-CoV-2 targets. The elite docked compounds with drug-like properties have a harmless ADMET profile, which may help to develop promising COVID-19 inhibitors.PMID:37861016 | DOI:10.2174/0115701638243222230920051050 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: V Alagarsamy V Raja Solomon S Murugesan P Shyam Sundar M D Muzaffar-Ur-Rehman Ala Chandu A Dharshini Aishwarya B Narendhar M T Sulthana V Ravikumar Source Type: research

Modeling the Antiviral Activity of Ginkgo Biloba Polyphenols Against Variola: In Silico Exploration of Inhibitory Candidates for Vartmpk and Hsstmpk Enzymes
CONCLUSION: Based on the obtained scores and Lipinski's rules, Liquiritin, Olivil, and ginkgolic acids molecules showed interesting results for both studied enzymes, indicating the existence of promising and moderate activity of these polyphenols for the treatment of variola and for possible multi-targeting. Liquiritin has been shown to exhibit anti-inflammatory effects on various inflammation- related diseases such as skin injury, hepatic inflammatory injury, and rheumatoid arthritis. Olivil has been shown to have antioxidant activity. Olivil derivatives have also been studied for their potential use as anticancer agents....
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: Sarra Hamdani Salim Bouchentouf Hocine Allali Source Type: research

Nutritional Profile, GC-MS Analysis and In-silico Anti-diabetic Phytocompounds Candidature of Jatropha gossypifolia Leaf Extracts
CONCLUSION: Benzene-1,2,4,5-tetramethyl from JGE extracts exhibited the most promising antidia- betic potential in-silico, suggesting its candidature as diabetes-target-protein inhibitor which may be developed for the treatment of type-2 diabetes mellitus.PMID:37817655 | DOI:10.2174/0115701638267143230925172207 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 11, 2023 Category: Drugs & Pharmacology Authors: Olasunkanmi Kayode Awote Rahmon Ilesanmi Kanmodi Success Chidera Ebube Zainab Folashade Abdulganniyyu Source Type: research

Nutritional Profile, GC-MS Analysis and In-silico Anti-diabetic Phytocompounds Candidature of Jatropha gossypifolia Leaf Extracts
CONCLUSION: Benzene-1,2,4,5-tetramethyl from JGE extracts exhibited the most promising antidiabetic potential in-silico, suggesting its candidature as diabetes-target-protein inhibitor which may be developed for the treatment of type-2 diabetes mellitus.PMID:37817655 | DOI:10.2174/0115701638267143230925172207 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 11, 2023 Category: Drugs & Pharmacology Authors: Olasunkanmi Kayode Awote Rahmon Ilesanmi Kanmodi Success Chidera Ebube Zainab Folashade Abdulganniyyu Source Type: research