Modeling the Antiviral Activity of Ginkgo Biloba Polyphenols Against Variola: In Silico Exploration of Inhibitory Candidates for Vartmpk and Hsstmpk Enzymes

CONCLUSION: Based on the obtained scores and Lipinski's rules, Liquiritin, Olivil, and ginkgolic acids molecules showed interesting results for both studied enzymes, indicating the existence of promising and moderate activity of these polyphenols for the treatment of variola and for possible multi-targeting. Liquiritin has been shown to exhibit anti-inflammatory effects on various inflammation- related diseases such as skin injury, hepatic inflammatory injury, and rheumatoid arthritis. Olivil has been shown to have antioxidant activity. Olivil derivatives have also been studied for their potential use as anticancer agents. Ginkgolic acids have been shown to have antimicrobial and antifungal properties. However, ginkgolic acids are also known to cause allergic reactions in some people. Therefore, future studies should consider these results and explore the potential of these compounds as antiviral agents. Further experimental studies in-vitro and in-vivo are required to validate and scale up these findings.PMID:37861017 | DOI:10.2174/0115701638261541230922095853
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Source Type: research