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Nutritional Profile, GC-MS Analysis and In-silico Anti-diabetic Phytocompounds Candidature of Jatropha gossypifolia Leaf Extracts
CONCLUSION: Benzene-1,2,4,5-tetramethyl from JGE extracts exhibited the most promising antidiabetic potential in-silico, suggesting its candidature as diabetes-target-protein inhibitor which may be developed for the treatment of type-2 diabetes mellitus.PMID:37817655 | DOI:10.2174/0115701638267143230925172207 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 11, 2023 Category: Drugs & Pharmacology Authors: Olasunkanmi Kayode Awote Rahmon Ilesanmi Kanmodi Success Chidera Ebube Zainab Folashade Abdulganniyyu Source Type: research

Development and In vitro Evaluation of Aceclofenac Buccal Film
CONCLUSION: Buccal films can be formulated using different polymers either individually or in combination to obtain the drug release profile required to achieve a desired treatment goal. Furthermore, the property of the buccal films depends on the type and concentration of the polymer used.PMID:37807409 | DOI:10.2174/0115701638262447230920061222 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 9, 2023 Category: Drugs & Pharmacology Authors: Samah Hamed Almurisi Ayah Mohammed Farah Qassem Heba Jehad Asma Jassim Khater Ahmed Saeed Al-JapairaI Rana Sammour Source Type: research

Inhibitory Effects of Carvacrol on Biofilm Formation in Colistin Heteroresistant Acinetobacter baumannii Clinical Isolates
CONCLUSION: The results of this study showed that sub-MIC of Carvacrol has anti-biofilm effects in clinical A.baumannii colistin hetero-resistance isolates.PMID:37779401 | DOI:10.2174/0115701638253395230919112548 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 2, 2023 Category: Drugs & Pharmacology Authors: Iraj Pakzad Fatemeh Yarkarami Behrooz Sadeghi Kalani Mahnaz Shafieian Ali Hematian Source Type: research

Computational Studies and Synthesis of New Heterocyclics as CNS Agents
CONCLUSION: The designed scheme was executed in the departmental laboratory. The chemical structure of the compounds was confirmed on the basis of TLC, IR, and 1HNMR analyses. The docking study revealed a good docking score of the compounds. The Log P value of the compounds indicated their good penetration into CNS. The compounds were also screened for anxiolytic activity. Among them, compounds 4f, 4h, and P3 showed maximum activity as anti-anxiolytic agents.PMID:37723630 | DOI:10.2174/1570163820666230918100218 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 19, 2023 Category: Drugs & Pharmacology Authors: Pooja Saini Sushil Kumar Source Type: research