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Comprehensive Review on Drug-target Interaction Prediction - Latest Developments and Overview
Curr Drug Discov Technol. 2023 Sep 6. doi: 10.2174/1570163820666230901160043. Online ahead of print.ABSTRACTDrug-target interactions (DTIs) are an important part of the drug development process. When the drug (a chemical molecule) binds to a target (proteins or nucleic acids), it modulates the biological behavior/function of the target, returning it to its normal state. Predicting DTIs plays a vital role in the drug discovery (DD) process as it has the potential to enhance efficiency and reduce costs. However, DTI prediction poses significant challenges and expenses due to the time-consuming and costly nature of experiment...
Source: Current Drug Discovery Technologies - September 8, 2023 Category: Drugs & Pharmacology Authors: Ali K Abdul Raheem Ban N Dhannoon Source Type: research

QSAR Studies and Scaffold Optimization of Predicted Novel ACC 2 Inhibitors to treat Metabolic Syndrome
CONCLUSION: The compounds designed in the present study have tremendous potential to yield orally active ACC 2 inhibitors to treat metabolic syndrome.PMID:37680153 | DOI:10.2174/1570163820666230901144003 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 8, 2023 Category: Drugs & Pharmacology Authors: Kirtika Madan Sarvesh Paliwal Swapnil Sharma Seema Kesar Neha Chauhan Mansi Madan Source Type: research

The Effect of Aloe Vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial
CONCLUSION: These findings are promising and suggest that Aloe vera may be a safe and effective adjunctive treatment for diabetic foot ulcers. However, further research is needed to confirm these results and to investigate the underlying mechanisms of aloe vera's therapeutic effect on diabetic foot ulcers.PMID:37670716 | DOI:10.2174/1570163820666230904150945 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - September 6, 2023 Category: Drugs & Pharmacology Authors: Parichehr Sabaghzadeh Irani Hadi Ranjbar Roghayeh Mehdipour-Rabori Mahya Torkaman Sudabeh Amirsalari Farshi Alazmani-Noode Source Type: research

Assessment of the In Vivo Reprotoxicity of Isotretinoin in Sprague-Dawley Male Rat
CONCLUSION: These observations suggest that ISO was reprotoxic, and future therapies should be further reassessed.PMID:37587808 | DOI:10.2174/1570163820666230816155855 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - August 17, 2023 Category: Drugs & Pharmacology Authors: Ahmad Khalil Mai Daradkeh Amneh Alrabie Hasan Abo Siam Source Type: research