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Repurposing Phytochemicals against Breast Cancer (MCF-7) using Classical Structure-Based Drug Design
CONCLUSION: The study suggests that compounds 162412 and 443440 could be useful for developing innovative anti-ERα medicines. However, more research is needed to prove the compounds' breast cancer treatment efficacy. This will help develop new treatments for ERα-associated breast cancer.PMID:38551041 | DOI:10.2174/0115701638295736240315105737 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 29, 2024 Category: Drugs & Pharmacology Authors: Faten Essam Hussain Aldoghachi Amjad Oraibi Noor Hamid Mohsen Sara S Hassan Source Type: research

Spinacia Oleracea: Exploring the Therapeutic Potential in Persian Medicine and Modern Pharmacology
CONCLUSION: Spinach exhibits a wide range of beneficial effects on various health conditions. Its widespread availability, low cost, and exceptional nutritional richness position it as a promising candidate for further investigation. Future studies should explore the clinical effectiveness of spinach in various diseases, while taking into consideration the principles emphasized in Persian medicine to guide research and inform therapeutic strategies.PMID:38549540 | DOI:10.2174/0115701638275971240201060710 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 29, 2024 Category: Drugs & Pharmacology Authors: Fatemeh Akbari Melika Mollaei Pendar Argani Babak Daneshfard Ali Reza Derakhshan Source Type: research

In-silico Studies, Synthesis, and Antacid Activities of Magnesium (II) Complexes
CONCLUSION: The antacid activities of Mg (II) complexes were excellent as compared to the semicarbazone ligand and comparable with that of marketed antacid drugs like ENO, and Pantop-D. Insilco studies also confirmed that semicarbazone ligand and its Mg (II) complexes were both found to be fitted into the active sites of molecular targets, and Mg (II) complexes showed better binding affinities towards macromolecular as compared to semicarbazone ligand.PMID:38509676 | DOI:10.2174/0115701638276401240315084143 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 21, 2024 Category: Drugs & Pharmacology Authors: Basuki Nath Jha Richa Kothari Anurag Agrawal Source Type: research

A Snapshot of Biomarkers in Psoriasis
Curr Drug Discov Technol. 2024 Mar 18. doi: 10.2174/0115701638278470240312075112. Online ahead of print.ABSTRACTA persistent long-standing, inflammatory skin condition that is brought on by a variety of factors is psoriasis. It is distinguished by itchy, scaly, reddish plaques, particularly on areas of the body that are frequently chafed, including the extensor sites of the limbs. Recent developments in molecular-targeted therapy that use biologics or small-molecule inhibitors can effectively cure even the worst psoriatic indications. The outstanding clinical outcomes of treatment help to clarify the disease's detrimental ...
Source: Current Drug Discovery Technologies - March 19, 2024 Category: Drugs & Pharmacology Authors: Krushna Abhale Addepalli Veeranjaneyulu Shivani Desai Source Type: research

Synthesis, Molecular Docking, and Biological Evaluation of Novel Indole--triazole Conjugates
CONCLUSION: In summary, our research underscores the efficacy of molecular hybridization in shaping the physicochemical, pharmacokinetic, and biological characteristics of novel indole-triazole derivatives.PMID:38482620 | DOI:10.2174/0115701638295739240222074426 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 14, 2024 Category: Drugs & Pharmacology Authors: Paras Berwal Suman Rohilla Nancy Mathur Ketki Rani Source Type: research