The Effect of Clusters of Double Triggering and Ineffective Efforts in Critically Ill Patients
OBJECTIVES: To characterize clusters of double triggering and ineffective inspiratory efforts throughout mechanical ventilation and investigate their associations with mortality and duration of ICU stay and mechanical ventilation. DESIGN: Registry-based, real-world study. Background: Asynchronies during invasive mechanical ventilation can occur as isolated events or in clusters and might be related to clinical outcomes. Subjects: Adults requiring mechanical ventilation greater than 24 hours for whom greater than or equal to 70% of ventilator waveforms were available. INTERVENTIONS: We identi...
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Catch Me If You Can—How Herpes Simplex Virus Tries to Evade Diagnosis in Viral Encephalitis*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Lung Ultrasound and Electrical Impedance as Long-Term Monitoring Tools for Acute Respiratory Failure: Sometimes No Numbers Are Better Than Bad (or Confusing) Numbers*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Should We Intubate Pediatric Hematopoietic Cell Transplant Patients With Respiratory Failure Sooner?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Can Early Electroencephalography Findings Predict Survival and Functional Outcome in Patients With Severe COVID-19 Infection?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Leveraging Robust Mixed Methodologies to Advance Implementation Research and Practice*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

REDOX REDUX? Glutamine, Catabolism, and the Urea-to-Creatinine Ratio as a Novel Nutritional Metric*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Hey, Community-Acquired Pneumonia Is Back on the Map!*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Predictive Algorithms for a Crisis*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

A Palace With a Common Tongue or a Multivariate Tower of Babel?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Temperature Management in the ICU
CONCLUSIONS: Body temperature management in critically ill patients remains an appealing therapy for several illnesses, and additional studies are needed to clarify management strategies and therapeutic pathways. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research

The Use and Duration of Preintubation Respiratory Support Is Associated With Increased Mortality in Immunocompromised Children With Acute Respiratory Failure*
CONCLUSIONS: In IC pediatric patients, preintubation exposure to HFNC and/or NIPPV is associated with increased odds of PICU mortality, independent of illness severity. Longer duration of exposure to HFNC/NIPPV prior to IMV is associated with increased mortality in HCT patients. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

Early Neuromuscular Electrical Stimulation in Addition to Early Mobilization Improves Functional Status and Decreases Hospitalization Days of Critically Ill Patients
CONCLUSIONS: The additional application of early NMES promoted better functional status outcomes on the first day awake and at ICU and hospital discharge. The patients in the EM+NMES group also took fewer days to stand up and had shorter hospital LOS, lower frequency of ICU-acquired weakness, and better muscle strength. Future studies are still necessary to clarify the effects of therapies associated with EM, especially to assess long-term outcomes. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Neurologic Critical Care Source Type: research

Early Clinical and Electrophysiological Brain Dysfunction Is Associated With ICU Outcomes in COVID-19 Critically Ill Patients With Acute Respiratory Distress Syndrome: A Prospective Bicentric Observational Study*
OBJECTIVES: Describe the prevalence of acute cerebral dysfunction and assess the prognostic value of an early clinical and electroencephalography (EEG) assessment in ICU COVID-19 patients. DESIGN: Prospective observational study. SETTING: Two tertiary critical care units in Paris, France, between April and December 2020. PATIENTS: Adult critically ill patients with COVID-19 acute respiratory distress syndrome. INTERVENTIONS: Neurologic examination and EEG at two time points during the ICU stay, first under sedation and second 4–7 days after sedation discontinuation. MEASUREMENTS AND MAI...
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Neurologic Critical Care Source Type: research

Lung-Dependent Areas Collapse, Monitored by Electrical Impedance Tomography, May Predict the Oxygenation Response to Prone Ventilation in COVID-19 Acute Respiratory Distress Syndrome
OBJECTIVES: ICUs have had to deal with a large number of patients with acute respiratory distress syndrome COVID-19, a significant number of whom received prone ventilation, which is a substantial consumer of care time. The selection of patients that we have to ventilate in prone position seems interesting. We evaluate the correlation between the percentage of collapsed dependent lung areas in the supine position, monitoring by electrical impedance tomography and the oxygenation response (change in Pao2/Fio2 ratio) to prone position. DESIGN: An observational prospective study. SETTING: From October 21, 20...
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research