The Challenge of Conducting Research in the Neonatal and Pediatric Age and of Translating Results Into Clinical Practice*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

The ICU Liberation ABCDEF Bundle: Utilization Among Critically Ill Little Adults*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

Why Predict What Time Will Tell? A Strategic Rationale for Predicting Prolonged Mechanical Ventilation After Subarachnoid Hemorrhage*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

Chimeric Antigen Receptor T Cells, the Shock of the New*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

Renin Kinetics and Mortality—Same, Same But Different?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

Preserving Equity and Quality in the Push to Increase Access to Critical Care Services*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

Sepsis Definitions: I Know It When I See It*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

Time for a New Approach Investigating and Eliminating Racial Inequities in the ICU*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research

Mortality Among Noncoronavirus Disease 2019 Critically Ill Patients Attributable to the Pandemic in France
Objectives: We investigated whether the risk of death among noncoronavirus disease 2019 critically ill patients increased when numerous coronavirus disease 2019 cases were admitted concomitantly to the same hospital units. Design: We performed a nationwide observational study based on the medical information system from all public and private hospitals in France. Setting: Information pertaining to every adult admitted to ICUs or intermediate care units from 641 hospitals between January 1, 2020, and June 30, 2020 was analyzed. Patients: A total of 454,502 patients (428,687 noncoronavirus disease 20...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Brief Report Source Type: research

Cardiac Output Measurement in Neonates and Children Using Noninvasive Electrical Bioimpedance Compared With Standard Methods: A Systematic Review and Meta-Analysis*
Conclusions: The meta-analyses demonstrated no significant difference between means of compared devices (except in neonatal stroke volume studies). The wide range of percentage error reported may be due to heterogeneity of study designs, devices, and populations included. Transthoracic electrical velocimetry/whole body electrical bioimpedance may be acceptable for use in child/adolescent populations, but validity in neonates and congenital heart disease patients remains uncertain. Larger studies in specific clinical contexts with standardized methodologies are required. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries*
Conclusions: ABCDEF bundle components have been adopted with substantial variability across regions. Additional research must rigorously evaluate the efficacy of specific elements with a focus on B, D, E, and full ABCDEF bundle implementation. Implementation science is needed to facilitate an understanding of the barriers to ABCDEF implementation and sustainability with a focus on specific cultural and regional differences. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

Factors Associated With Prolonged Mechanical Ventilation in Patients With Subarachnoid Hemorrhage—The RAISE Score*
CONCLUSIONS: Initial disease severity and neuroimaging findings detected within 24 hours after ICU admission were associated with the need for prolonged mechanical ventilation in patients with subarachnoid hemorrhage. These results may be helpful for patient families and caregivers to better anticipate the course of therapy. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Neurologic Critical Care Source Type: research

Association of Proximity to a Long-Term Acute Care Hospital With Hospital Tracheostomy Practices
OBJECTIVES: Availability of long-term acute care hospitals has been associated with hospital discharge practices. It is unclear if long-term acute care hospital availability can influence patient care decisions. We sought to determine the association of long-term acute care hospital availability at different hospitals with the likelihood of tracheostomy. DESIGN: Retrospective cohort study. SETTING: California Patient Discharge Database, 2016–2018. PATIENTS: Adult patients receiving mechanical ventilation for respiratory failure. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Us...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Critically Ill Patients Treated for Chimeric Antigen Receptor-Related Toxicity: A Multicenter Study*
CONCLUSIONS: This is the first study to describe a multicenter cohort of patients requiring ICU admission with cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy. Despite severe toxicities, organ support and in-hospital mortality were low in this patient population. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Trends in Endotracheal Intubation During In-Hospital Cardiac Arrests: 2001–2018
OBJECTIVES: Airway management during in-hospital cardiac arrest represents a fundamental component of resuscitative efforts, yet little is known about temporal trends in intubation during in-hospital cardiac arrest. Our objective was to investigate changes in in-hospital cardiac arrest airway management over time and in response to national guideline updates. DESIGN: Observational cohort study of a prospectively collected database. SETTING: Multicenter study of hospitals participating in the “Get With The Guidelines—Resuscitation” registry from January 1, 2001, to December 31, 2018. SUBJECTS: ...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research