High-Dose Vitamin C: How an Orange Can Be a Lemon
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research
The β1-Adrenergic Receptor Contributes to Sepsis-Induced Immunosuppression Through Modulation of Regulatory T-Cell Inhibitory Function*
CONCLUSIONS:
β1-adrenergic receptor activation enhances regulatory T lymphocyte inhibitory function and thus contributes to sepsis-induced immunosuppression. This can be attenuated by β1-adrenergic receptor blockade, suggesting a potential immunoregulatory role for this therapy in the management of sepsis. (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
Tidal Volume–Dependent Activation of the Renin-Angiotensin System in Experimental Ventilator-Induced Lung Injury*
CONCLUSIONS:
VILI is accompanied by a strong activation of the RAS. Based on circulating Ang metabolite levels and tissue expression of RAS enzymes, classical ACE-dependent and alternative RAS cascades were activated in the HVT group, whereas classical RAS activation prevailed with VHVT ventilation. Ang 1–7 or captopril protected from VILI primarily by modifying the systemic RAS profile. (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
Adrenergic Immune Effects: Is Beta the Enemy of Good?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
The Renin-Angiotensin System in Acute Lung Injury*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Do We Need an ICU for All Elective Postcraniotomy Patients? A Critical Appraisal*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Moving to the Head of the “Claza”—Targeting Interleukin-6 for COVID-19 Pneumonia
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Transient Acute Kidney Injury Versus Persistent Acute Kidney Injury in Acute Liver Failure—Helpful Differentiation or Confusing Dichotomization*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Optimizing Pharmacist Impact in Critically Ill Patients: Is Medication Regimen Complexity the Answer?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Sex, Renin Angiotensin System Inhibitors, and COVID-19 Severity: Biologic Divergence or Healthcare Disparity?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
More Documentation? Who Needs It?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Reexamining the Role of Postoperative ICU Admission for Patients Undergoing Elective Craniotomy: A Systematic Review*
CONCLUSIONS:
Overall, these studies suggest that non-ICU care pathways for appropriately selected postcraniotomy patients may represent a meaningful opportunity to improve care value. However, included studies varied greatly in patient selection, postoperative care protocol, and outcomes reporting. Standardization and multi-institutional collaboration are needed to draw definitive conclusions regarding non-ICU postoperative care for elective craniotomy. (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Review Article Source Type: research
Critical Appraisal of a Systematic Review: A Concise Review
CONCLUSIONS:
Systematic reviews are transparent and reproducible summaries of research and conclusions drawn from them are only as credible and reliable as their development process and the studies which form the systematic review. Applying evidence from a systematic review to patient care considers whether the results can be directly applied, whether all important outcomes have been considered, and if the benefits are worth potential harms and costs. (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research
Tracheostomy Practices and Outcomes in Patients With COVID-19 Supported by Extracorporeal Membrane Oxygenation: An Analysis of the Extracorporeal Life Support Organization Registry
OBJECTIVES:
The use of extracorporeal membrane oxygenation (ECMO) in patients with COVID-19 has been supported by major healthcare organizations, yet the role of specific management strategies during ECMO requires further study. We sought to characterize tracheostomy practices, complications, and outcomes in ECMO-supported patients with acute respiratory failure related to COVID-19.
DESIGN:
Retrospective cohort study.
SETTING:
ECMO centers contributing to the Extracorporeal Life Support Organization Registry.
PATIENTS:
Patients 16 years or older receiving venovenous ECMO for respiratory support for...
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation*
CONCLUSIONS:
Clazakizumab significantly improved 28-day ventilator-free survival, 28- and 60-day overall survival, as well as clinical outcomes in hospitalized patients with COVID-19 and hyperinflammation. (Source: Critical Care Medicine)
Source: Critical Care Medicine - August 24, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
