Thrombocytopenia After Coronavirus Disease 2019 Vaccination: Remember to Put the Blame on Others Too
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Sedation, Neuromuscular Blockade, and Mortality in Acute Respiratory Distress Syndrome: Important Questions Remain
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Concerning the Association Between Delayed Administration of Antibiotics and Mortality in Patients With Suspected Sepsis
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia
CONCLUSIONS: Vaccine-induced immune thrombotic thrombocytopenia is a serious complication of vaccination that is not feasible to anticipate or prevent. When the patient presents with sustained headache, neurologic symptoms/signs, abdominal pain, dyspnea, or limb pain/swelling beginning 5–30 days post vaccination, platelet count and d-dimer must be measured, and imaging for thrombosis performed. Confirmation of vaccine-induced immune thrombotic thrombocytopenia diagnosis should be ordered (platelet factor 4/polyanion enzyme-linked immunosorbent assay; platelet factor 4–enhanced platelet activation testing) as treatm...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Review Article Source Type: research

Molar Sodium Lactate Attenuates the Severity of Postcardiac Arrest Syndrome: A Preclinical Study
OBJECTIVES: To determine whether continuous IV infusion of molar sodium lactate would limit cardiac arrest–induced neurologic injury and cardiovascular failure. DESIGN: Randomized blinded study (animal model). SETTING: University animal research facility. SUBJECTS: Twenty-four adult male “New Zealand White” rabbits. INTERVENTIONS: Anesthetized rabbits underwent 12.5 minutes of asphyxial cardiac arrest and were randomized to receive either normal saline (control group, n = 12) or molar sodium lactate (molar sodium lactate group, n = 12) at a rate of 5 mL/kg/hr during the whole 120-min...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Noninvasive Tidal Volume Measurements, Using a Time-of-Flight Camera, Under High-Flow Nasal Cannula—A Physiological Evaluation, in Healthy Volunteers*
OBJECTIVES: The mechanisms of high-flow nasal cannula are still debated but may be mediated by the generation of low positive end-expiratory pressure and a washout of the airway dead space. The aims of this study were to assess the effects of high-flow nasal cannula on tidal volume using a noninvasive method using a time-of-flight camera, under various conditions. DESIGN: A physiologic evaluation in healthy volunteers. SETTING: An university hospital ICU. SUBJECTS: Ten healthy volunteers were included in a physiologic study (CamOpt study, ClinicalTrials.gov identifier: NCT04096183). INTERVENTION...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Left Ventricular Function Changes Induced by Moderate Hypothermia Are Rapidly Reversed After Rewarming—A Clinical Study
OBJECTIVES: Targeted temperature management (32–36°C) is used for neuroprotection in cardiac arrest survivors. The isolated effects of hypothermia on myocardial function, as used in clinical practice, remain unclear. Based on experimental results, we hypothesized that hypothermia would reversibly impair diastolic function with less tolerance to increased heart rate in patients with uninsulted hearts. DESIGN: Prospective clinical study, from June 2015 to May 2018. SETTING: Cardiothoracic surgery operation room, Oslo University Hospital. PATIENTS: Twenty patients with left ventricular ejection fra...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry
Objectives: Multicenter data on the characteristics and outcomes of children hospitalized with coronavirus disease 2019 are limited. Our objective was to describe the characteristics, ICU admissions, and outcomes among children hospitalized with coronavirus disease 2019 using Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 registry. Design: Retrospective study. Setting: Society of Critical Care Medicine Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) registry. Patients: Children ( (Sourc...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Dielectric Blood Coagulometry for the Early Detection of Sepsis-Induced Disseminated Intravascular Coagulation: A Prospective Observational Study
Objectives: To evaluate the utility of dielectric blood coagulometry for early sepsis–induced disseminated intravascular coagulation diagnosis. Design: Single-center, prospective observational study. Setting: Patients with sepsis or septic shock at the Tokyo Medical and Dental University Hospital of Medicine between September 2019 and September 2020. Patients: The patients were divided into three groups according to the timing of disseminated intravascular coagulation diagnosis based on the Disseminated Intravascular Coagulation score by the Japanese Association for Acute Medicine: 1) no dissemin...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Components of Health-Related Quality of Life Most Affected Following Pediatric Critical Illness
OBJECTIVES: To evaluate which individual elements of health-related quality of life contribute most to decline in overall health-related quality of life status following pediatric critical care. DESIGN: Retrospective cohort study. SETTING: Seattle Children’s Hospital. PATIENTS: ICU patients age 1 month to 18 years admitted between December 2011 and February 2017. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We assessed health-relatedquality of life decline from baseline to postdischarge (median, 6 wk) and determined the individual items of the Pediatric Quality of Life Inve...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S)
OBJECTIVES: Delirium is a common and frequently underdiagnosed complication in acutely hospitalized patients, and its severity is associated with worse clinical outcomes. We propose a physiologically based method to quantify delirium severity as a tool that can help close this diagnostic gap: the Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S). DESIGN: Retrospective cohort study. SETTING: Single-center tertiary academic medical center. PATIENTS: Three-hundred seventy-three adult patients undergoing electroencephalography to evaluate altered mental status between August ...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Body Mass Index and Mortality in Coronavirus Disease 2019 and Other Diseases: A Cohort Study in 35,506 ICU Patients
CONCLUSIONS: The obesity paradox, which is the inverse association between body mass index and mortality in critically ill patients, is not present in ICU patients with coronavirus disease 2019–related respiratory failure, in contrast to nonsevere acute respiratory syndrome coronavirus 2 viral and bacterial respiratory infections. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Is Time-of-Flight Ready for Take Off to Measure Patient Self-Inflicted Lung Injury?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Editorials Source Type: research