The Intriguing, Still Undercovered, Clinical Role of Echocardiography in Critically Ill Coronavirus Disease Patients
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Right Ventricular Dysfunction and Its Association With Mortality in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Do Not Focus on Not Reliable Markers!
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Phospholipid Screening Postcardiac Arrest Detects Decreased Plasma Lysophosphatidylcholine: Supplementation as a New Therapeutic Approach
CONCLUSIONS: Our data suggest that decreased plasma lysophosphatidylcholine is a major contributor to mortality and brain damage postcardiac arrest, and its supplementation may be a novel therapeutic approach. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Exogenous Nicotinamide Adenine Dinucleotide Attenuates Postresuscitation Myocardial and Neurologic Dysfunction in a Rat Model of Cardiac Arrest
OBJECTIVES: To investigate the therapeutic potential and underlying mechanisms of exogenous nicotinamide adenine dinucleotide+ on postresuscitation myocardial and neurologic dysfunction in a rat model of cardiac arrest. DESIGN: Thirty-eight rats were randomized into three groups: 1) Sham, 2) Control, and 3) NAD. Except for the sham group, untreated ventricular fibrillation for 6 minutes followed by cardiopulmonary resuscitation was performed in the control and NAD groups. Nicotinamide adenine dinucleotide+ (20 mg/kg) was IV administered at the onset of return of spontaneous circulation. SETTING: Univers...
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Unassisted Return of Spontaneous Circulation Following Withdrawal of Life-Sustaining Therapy During Donation After Circulatory Determination of Death in a Child
CONCLUSIONS: We provide the first report of unassisted return of spontaneous circulation following withdrawal of life-sustaining treatment in a child. In our case, return of spontaneous circulation occurred in the setting of controlled donation after circulatory determination of death and was accompanied by return of respiration. Return of spontaneous circulation greater than 2 minutes following circulatory arrest in our patient indicates that 2 minutes of observation is insufficient to ensure that cessation of circulation is permanent after withdrawal of life-sustaining treatment in a child. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Case Report Source Type: research

Extracorporeal Life Support for Respiratory Failure in Patients With Electronic Cigarette or Vaping Product Use–Associated Lung Injury
CONCLUSIONS: Electronic cigarette or vaping product use–associated lung injury can cause refractory respiratory failure and hypoxemia. These data suggest that venovenous extracorporeal life support can be an effective treatment option for profound, refractory respiratory failure secondary to electronic cigarette or vaping product use–associated lung injury. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Comparison of Machine Learning Methods for Predicting Outcomes After In-Hospital Cardiac Arrest
In this study, we derive and compare the performance of several machine learning models with each other and with the Cardiac Arrest Survival Post-Resuscitation In-hospital score for predicting the likelihood of favorable neurologic outcomes among survivors of resuscitation. DESIGN: Analysis of the Get With The Guidelines-Resuscitation registry. SETTING: Seven-hundred fifty-five hospitals participating in Get With The Guidelines-Resuscitation from January 1, 2001, to January 28, 2017. PATIENTS: Adult in-hospital cardiac arrest survivors. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: ...
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Rapid Development and Deployment of an Intensivist-Led Venovenous Extracorporeal Membrane Oxygenation Cannulation Program
CONCLUSIONS: There is no difference between success and complication rates of percutaneous venovenous extracorporeal membrane oxygenation canulation when performed by cardiothoracic surgeons versus medical intensivist in an already established extracorporeal membrane oxygenation program. A rapidly deployed cannulation program by intensivists for venovenous extracorporeal membrane oxygenation can be performed with high success and low complication rates. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Anisocoria and Poor Pupil Reactivity by Quantitative Pupillometry in Patients With Intracranial Pathology
CONCLUSIONS: New onset anisocoria occurs in over 60% of patients with neurologic emergencies. Pupil reactivity may be an important distinguishing characteristic of clinically relevant new onset anisocoria phenotypes. New onset anisocoria accompanied by objective evidence of abnormal pupil reactivity was associated with midline shift, and new onset anisocoria accompanied by objective evidence of normal pupil reactivity had an inverse relationship with death. Distinct quantitative pupil characteristics precede new onset anisocoria occurrence and may allow for earlier prediction of neurologic decline. Further work is need...
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial
CONCLUSIONS: In the context of out-of-hospital cardiac arrest with shockable rhythm and no ST-elevation, treatment with mild therapeutic hypothermia was not associated with improved 90-day survival compared with targeted normothermia. Neurologic outcomes at 90 days as well as patient-reported Mental and Physical Health Scores at 1 year did not differ between the groups. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Association of Socioeconomic Status With Postdischarge Pediatric Resource Use and Quality of Life
This study examines the associations between socioeconomic status, resource use, and health-related quality of life in a cohort of children recovering from acute respiratory failure. DESIGN: Secondary analysis of data from the Randomized Evaluation of Sedation Titration for Respiratory Failure clinical trial. SETTING: Thirty-one PICUs. PATIENTS: Children with acute respiratory failure enrolled whose parent/guardians consented for follow-up. MEASUREMENTS AND MAIN RESULTS: Resource use included in-home care, number of healthcare providers, prescribed medications, home medical equipment, emergency ...
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Evaluating the Balance Between Privacy and Access in Digital Information Sharing
CONCLUSIONS: In the context of an ICU admission, sharing personal health information with a person of the patient’s choosing appears desirable for most patients and family members. Policies and implementation of regulations should take this into consideration. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Online Editorial Board Acknowledgment
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Editorial Board Acknowledgment Source Type: research

Pediatric Delirium: We Have Come a Long Way, and We Have Only Just Begun*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research