Postmortem Evidence of Brain Inflammatory Markers and Injury in Septic Patients: A Systematic Review
CONCLUSIONS: The mechanisms by which sepsis induces brain dysfunction are likely to include vascular and neuronal lesions, followed by the activation of glial cells and the presence of peripheral immune cells in the brain. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Electrical Impedance Tomography Monitoring of Bronchoalveolar Lavage in Patients With Acute Respiratory Distress Syndrome
CONCLUSIONS: The negative impact of bronchoalveolar lavage on regional ventilation, which persisted at least 6 hours, appeared to be more profound in patients with normal lung function or mild acute respiratory distress syndrome. In contrast, regional ventilation, lung recruitment, respiratory mechanics, and gas exchanges were modestly impacted by the bronchoalveolar lavage in patients with severe or moderate acute respiratory distress syndrome. That finding is reassuring and supports not summarily proscribing bronchoalveolar lavage for the most severely ill with acute respiratory distress syndrome. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Pathophysiologic Signature of Impending ICU Hypoglycemia in Bedside Monitoring and Electronic Health Record Data: Model Development and External Validation
CONCLUSIONS: We used data from a large number of critically ill inpatients to develop and externally validate a predictive model of impending ICU hypoglycemia. Future steps include incorporating this model into a clinical decision support system and testing its effects in a multicenter randomized controlled clinical trial. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Bursting at the Seams: Barotrauma in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Why Clinicians Should Adopt Routine Neuroimaging After Extracorporeal Membrane Oxygenation*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

The IMPACT of Transitional Care Management in Sepsis*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Is Ventilator-Associated Pneumonia More Frequent in Patients With Coronavirus Disease 2019?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Taking a New SLANT on Postcardiac Arrest Prognostication?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Improving Sepsis Care: Is It Research? Promoting Clarity in a Zone of Confusion*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Panacea or Perplexing?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Tocilizumab: A Role for Biomarker-Directed Therapy?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Time Out: More Observation Time to Allow for Stronger Science, Sharper Prognostic Tools, and Better Outcomes in Cardiac Arrest Survivors*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Physical Rehabilitation in the ICU: Is It Worth the Effort?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Pediatric Acute Respiratory Distress Syndrome—Will We Be Able to Predict It and Eventually Prevent It?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Barotrauma in Coronavirus Disease 2019 Patients Undergoing Invasive Mechanical Ventilation: A Systematic Literature Review*
CONCLUSIONS: Barotrauma occurs in one out of six coronavirus disease 2019 acute respiratory distress syndrome patients receiving invasive mechanical ventilation and is associated with a mortality rate of about 60%. Barotrauma rate may be higher than noncoronavirus disease 2019 controls. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Review Article Source Type: research