Bayesian Models for Therapeutic Monitoring of Vancomycin in the Critically Ill: What Should They Predict?
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Hyperoxia on Venoarterial Extracorporeal Membrane Oxygenation: A Modifiable Risk?
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Possible Underestimation of Cerebral Hyperoxia in Patients With Left Ventricular Output Encountering With Extracorporeal Membrane Oxygenation Flow at the Aortic Arch
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Potential Confounders in Evaluating the Impact of Hyperoxia on Neurological Outcomes in Patients Receiving Extracorporeal Membrane Oxygenation
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Coronavirus Disease-Induced Blurred Judgment
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Thrombocytopenia After Coronavirus Disease 2019 Vaccination: Remember to Put the Blame on Others Too
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Sedation, Neuromuscular Blockade, and Mortality in Acute Respiratory Distress Syndrome: Important Questions Remain
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Concerning the Association Between Delayed Administration of Antibiotics and Mortality in Patients With Suspected Sepsis
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia
CONCLUSIONS: Vaccine-induced immune thrombotic thrombocytopenia is a serious complication of vaccination that is not feasible to anticipate or prevent. When the patient presents with sustained headache, neurologic symptoms/signs, abdominal pain, dyspnea, or limb pain/swelling beginning 5–30 days post vaccination, platelet count and d-dimer must be measured, and imaging for thrombosis performed. Confirmation of vaccine-induced immune thrombotic thrombocytopenia diagnosis should be ordered (platelet factor 4/polyanion enzyme-linked immunosorbent assay; platelet factor 4–enhanced platelet activation testing) as treatm...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Review Article Source Type: research

Molar Sodium Lactate Attenuates the Severity of Postcardiac Arrest Syndrome: A Preclinical Study
OBJECTIVES: To determine whether continuous IV infusion of molar sodium lactate would limit cardiac arrest–induced neurologic injury and cardiovascular failure. DESIGN: Randomized blinded study (animal model). SETTING: University animal research facility. SUBJECTS: Twenty-four adult male “New Zealand White” rabbits. INTERVENTIONS: Anesthetized rabbits underwent 12.5 minutes of asphyxial cardiac arrest and were randomized to receive either normal saline (control group, n = 12) or molar sodium lactate (molar sodium lactate group, n = 12) at a rate of 5 mL/kg/hr during the whole 120-min...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Noninvasive Tidal Volume Measurements, Using a Time-of-Flight Camera, Under High-Flow Nasal Cannula—A Physiological Evaluation, in Healthy Volunteers*
OBJECTIVES: The mechanisms of high-flow nasal cannula are still debated but may be mediated by the generation of low positive end-expiratory pressure and a washout of the airway dead space. The aims of this study were to assess the effects of high-flow nasal cannula on tidal volume using a noninvasive method using a time-of-flight camera, under various conditions. DESIGN: A physiologic evaluation in healthy volunteers. SETTING: An university hospital ICU. SUBJECTS: Ten healthy volunteers were included in a physiologic study (CamOpt study, ClinicalTrials.gov identifier: NCT04096183). INTERVENTION...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Left Ventricular Function Changes Induced by Moderate Hypothermia Are Rapidly Reversed After Rewarming—A Clinical Study
OBJECTIVES: Targeted temperature management (32–36°C) is used for neuroprotection in cardiac arrest survivors. The isolated effects of hypothermia on myocardial function, as used in clinical practice, remain unclear. Based on experimental results, we hypothesized that hypothermia would reversibly impair diastolic function with less tolerance to increased heart rate in patients with uninsulted hearts. DESIGN: Prospective clinical study, from June 2015 to May 2018. SETTING: Cardiothoracic surgery operation room, Oslo University Hospital. PATIENTS: Twenty patients with left ventricular ejection fra...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research