Improving Timeliness of Antibiotic Administration Using a Provider and Pharmacist Facing Sepsis Early Warning System in the Emergency Department Setting: A Randomized Controlled Quality Improvement Initiative*
CONCLUSIONS: In this single-center randomized quality improvement initiative, the display of an electronic health record–based sepsis early warning system–triggered flag combined with electronic health record–based pharmacist notification was associated with shorter time to antibiotic administration without an increase in undesirable or potentially harmful clinical interventions. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Race Does Not Impact Sepsis Outcomes When Considering Socioeconomic Factors in Multilevel Modeling
CONCLUSIONS: Our study demonstrates that race is not an independent risk factor for sepsis mortality, as well as sepsis-related length of stay. We should expand our inquiry into determinants of sepsis outcomes by including socioeconomic variables. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial*
CONCLUSIONS: Multiple biomarkers prognostic for clinical outcomes were confirmed in COVACTA. Ferritin was identified as a predictive biomarker for the effects of tocilizumab in the COVACTA patient population; high ferritin levels were associated with better clinical outcomes for tocilizumab compared with placebo at day 28. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Should We Prolong the Observation Period for Neurological Recovery After Cardiac Arrest?*
CONCLUSIONS: Up to 9.6% of cardiac arrest patients with favorable outcomes recover consciousness after the recommended 7 days of observation, indicating the observation time of 7 days seems justified but longer duration may be needed. The results of the culturally and clinically isolated population may limit the application to other population. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Physical Rehabilitation in the ICU: A Systematic Review and Meta-Analysis*
CONCLUSIONS: Physical rehabilitation in the ICU improves physical function and reduces ICU and hospital length of stay. However, it does not appear to impact other outcomes. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study*
In this study, we aimed to characterize the frequency and outcomes of children meeting “at risk for pediatric acute respiratory distress syndrome” criteria as defined by the Pediatric Acute Lung Injury Consensus Conference. DESIGN: Planned substudy of the prospective multicenter, international Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology study conducted during 10 nonconsecutive weeks (May 2016–June 2017). SETTING: Thirty-seven international PICUs. PATIENTS: Three-hundred ten critically ill children meeting Pediatric Acute Lung Injury Consensus Conference “at-risk for...
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Association Between Pandemic Coronavirus Disease 2019 Public Health Measures and Reduction in Critical Care Utilization Across ICUs in Alberta, Canada
OBJECTIVES: The coronavirus disease 2019 pandemic has disrupted critical care services across the world. In anticipation of surges in the need for critical care services, governments implemented “lockdown” measures to preserve and create added critical care capacity. Herein, we describe the impact of lockdown measures on the utilization of critical care services and patient outcomes compared with nonlockdown epochs in a large integrated health region. DESIGN: This was a population-based retrospective cohort study. SETTING: Seventeen adult ICUs across 14 acute care hospitals in Alberta, Canada. PATI...
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients: Erratum
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Errata Source Type: research

Orange You Wishing There Were Definitive Randomized Controlled Trials Already?: Erratum
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Errata Source Type: research

21st Century Evidence: Randomized Controlled Trials Versus Systematic Reviews and Meta-Analyses: Erratum
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Errata Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Efficacy and Safety of Corticosteroid Therapy in Patients With Cardiac Arrest
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Hemoglobin Level at Admission Is Less Important
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 1, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research