Herpes Simplex Virus Encephalitis With Initial Negative Polymerase Chain Reaction in the Cerebrospinal Fluid: Prevalence, Associated Factors, and Clinical Impact*
OBJECTIVES:
To describe the prevalence, associated factors, and clinical impact of an initial negative herpes simplex virus (HSV) polymerase chain reaction (PCR) in critically ill patients with PCR-proven HSV encephalitis.
DESIGN:
Retrospective multicenter study from 2007 to 2017.
SETTING:
Forty-seven French ICUs.
PATIENTS:
Critically ill patients admitted to the ICU with possible/probable acute encephalitis and a positive cerebrospinal fluid (CSF) PCR for HSV.
INTERVENTIONS:
None.
MEASUREMENTS AND MAIN RESULTS:
We included 273 patients with a median Glasgow Coma Scale score of 9 (6â€...
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Online Brief Reports Source Type: research
Validation of Respiratory Rate-Oxygenation Index in Patients With COVID-19–Related Respiratory Failure
This study aimed to validate ROX in a cohort of inpatients with COVID-19–related respiratory failure.
DESIGN:
Retrospective validation of the ROX index. We calculated sensitivity, specificity, positive predictive value, negative predictive value, and 95% CIs of ROX for invasive mechanical ventilation any time during hospitalization.
SETTING:
Twenty-one hospitals of Kaiser Permanente Northern California, an integrated healthcare delivery system.
PATIENTS:
We identified adults with positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test within 3 weeks of, or during, hosp...
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Online Brief Reports Source Type: research
Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury*
OBJECTIVES:
Lung damage during mechanical ventilation involves lung volume and alveolar water content, and lung ultrasound (LUS) and electrical impedance tomography changes are related to these variables. We investigated whether these techniques may detect any signal modification during the development of ventilator-induced lung injury (VILI).
DESIGN:
Experimental animal study.
SETTING:
Experimental Department of a University Hospital.
Subjects:
Forty-two female pigs (24.2 ± 2.0 kg).
INTERVENTIONS:
The animals were randomized into three groups (n = 14): high tidal volume (TV) (mean TV, 803....
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
The Effect of Clusters of Double Triggering and Ineffective Efforts in Critically Ill Patients
OBJECTIVES:
To characterize clusters of double triggering and ineffective inspiratory efforts throughout mechanical ventilation and investigate their associations with mortality and duration of ICU stay and mechanical ventilation.
DESIGN:
Registry-based, real-world study.
Background:
Asynchronies during invasive mechanical ventilation can occur as isolated events or in clusters and might be related to clinical outcomes.
Subjects:
Adults requiring mechanical ventilation greater than 24 hours for whom greater than or equal to 70% of ventilator waveforms were available.
INTERVENTIONS:
We identi...
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
Catch Me If You Can—How Herpes Simplex Virus Tries to Evade Diagnosis in Viral Encephalitis*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Lung Ultrasound and Electrical Impedance as Long-Term Monitoring Tools for Acute Respiratory Failure: Sometimes No Numbers Are Better Than Bad (or Confusing) Numbers*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Should We Intubate Pediatric Hematopoietic Cell Transplant Patients With Respiratory Failure Sooner?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Can Early Electroencephalography Findings Predict Survival and Functional Outcome in Patients With Severe COVID-19 Infection?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Leveraging Robust Mixed Methodologies to Advance Implementation Research and Practice*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
REDOX REDUX? Glutamine, Catabolism, and the Urea-to-Creatinine Ratio as a Novel Nutritional Metric*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Hey, Community-Acquired Pneumonia Is Back on the Map!*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Predictive Algorithms for a Crisis*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
A Palace With a Common Tongue or a Multivariate Tower of Babel?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research
Temperature Management in the ICU
CONCLUSIONS:
Body temperature management in critically ill patients remains an appealing therapy for several illnesses, and additional studies are needed to clarify management strategies and therapeutic pathways. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research
The Use and Duration of Preintubation Respiratory Support Is Associated With Increased Mortality in Immunocompromised Children With Acute Respiratory Failure*
CONCLUSIONS:
In IC pediatric patients, preintubation exposure to HFNC and/or NIPPV is associated with increased odds of PICU mortality, independent of illness severity. Longer duration of exposure to HFNC/NIPPV prior to IMV is associated with increased mortality in HCT patients. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research
