Use of Airway Pressure Release Ventilation in Patients With Acute Respiratory Failure Due to COVID-19: Results of a Single-Center Randomized Controlled Trial*
OBJECTIVES: Airway pressure release ventilation is a ventilatory mode characterized by a mandatory inverse inspiratory:expiratory ratio with a very short expiratory phase, aimed to avoid derecruitment and allow spontaneous breathing. Recent basic and clinical evidence suggests that this mode could be associated with improved outcomes in patients with acute respiratory distress syndrome. The aim of this study was to compare the outcomes between airway pressure release ventilation and traditional ventilation targeting low tidal volume, in patients with severe coronavirus disease 2019. DESIGN: Single-center randomi...
Source: Critical Care Medicine - April 1, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

The Association Between the Decision to Withdraw Life-Sustaining Therapy and Patient Mortality in U.K. ICUs*
CONCLUSIONS: Decision to withdraw or withhold life-sustaining treatment in critically ill adults in the United Kingdom was associated with increased 180-day mortality in the marginal patients. The increased mortality from a decision to withdraw or withhold life-sustaining treatment in the marginal patient may be informative when establishing patients’ preferences and evaluating the cost-effectiveness of intensive treatments. (Source: Critical Care Medicine)
Source: Critical Care Medicine - April 1, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Immune Profiling Demonstrates a Common Immune Signature of Delayed Acquired Immunodeficiency in Patients With Various Etiologies of Severe Injury*
CONCLUSIONS: Using REAnimation Low Immune Status Marker immunomonitoring panel, we detected delayed injury-acquired immunodeficiency in a subgroup of severely injured patients independently of primary disease. Critically ill patients’ immune status could be captured through the combined monitoring of a common panel of complementary markers of pro-/anti-inflammatory, innate, and adaptive immune responses. Such immune monitoring needs to be incorporated in larger study cohorts with more extensive immune surveillance to develop specific hypothesis allowing for identification of biological systems affecting altered immun...
Source: Critical Care Medicine - April 1, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Risk of Dementia and Structural Brain Changes Following Nonneurological Infections During 9-Year Follow-Up*
CONCLUSIONS: In this 9-year observational follow-up study, sepsis episodes were associated with subsequent development of dementia. Nonneurologic infections had no effect on the trajectory of structural cerebral changes. (Source: Critical Care Medicine)
Source: Critical Care Medicine - April 1, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Benchmarking Inpatient Mortality Using Electronic Medical Record Data: A Retrospective, Multicenter Analytical Observational Study*
CONCLUSIONS: Variables considered by traditional ICU prognostic models accurately benchmark patient mortality for patients receiving care in multiple hospital locations, not only the ICU. Unlike Acute Physiology and Chronic Health Evaluation, this model relies on electronic medical record data alone and does not require personnel to collect the independent predictor variables. Assessing the model’s utility for benchmarking hospital performance will require prospective testing in a larger representative sample of hospitals. (Source: Critical Care Medicine)
Source: Critical Care Medicine - April 1, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Diversity of Authors of Publications From the Canadian Critical Care Trials Group*
CONCLUSIONS: Authors of Canadian Critical Care Trials Group publications are diverse with regard to demographic and professional characteristics. (Source: Critical Care Medicine)
Source: Critical Care Medicine - April 1, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Hysteresis and Lung Recruitment in Acute Respiratory Distress Syndrome Patients: A CT Scan Study: Erratum
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Erratum Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

Altered Metabolic Resource Allocation May Play Important Role in Multiple Organ Dysfunction Syndrome
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

Look Back, Look Forward, but Use a Fresh Look
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

The author replies
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

How to Preserve Quality of Life Following Extracorporeal Membrane Oxygenation Explantation
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

The RAISE Score: A Possible Tool to Better Identify Subarachnoid Hemorrhage Patients Who Might Benefit From Early Tracheostomy?
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research