Patient Harm and Institutional Avoidability of Out-of-Hours Discharge From Intensive Care: An Analysis Using Mixed Methods*
CONCLUSIONS: We identified significant limitations in out-of-hours care provision following overnight discharge from ICU. Transfer to the ward before 16:00 should be facilitated where possible. Our work highlights changes to help make day time discharge more likely. Where discharge after 16:00 is unavoidable, support systems should be implemented to ensure the safety of patients discharged from ICU at night. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial*
CONCLUSIONS: The catabolic phenotype measured by increased urea-to-creatinine ratio is associated with increased risk of death during prolonged ICU stay and signals the deleterious effects of glutamine administration in the REDOXS study. Urea-to-creatinine ratio is a promising catabolic signature and potential interventional target. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Etiology, Treatments, and Outcomes of Patients With Severe Community-Acquired Pneumonia in a Large U.S. Sample*
OBJECTIVES: Compare the clinical practice and outcomes in severe community-acquired pneumonia (sCAP) patients to those in non-sCAP patients using guideline-defined criteria for sCAP. DESIGN: Retrospective observational cohort study. SETTING: One hundred seventy-seven U.S. hospitals within the Premier Healthcare Database. PATIENTS: Hospitalized adult (≥ 18 yr old) patients with pneumonia. MEASUREMENTS AND MAIN RESULTS: Adult patients (≥ 18 yr old) with a principal diagnosis of pneumonia or a secondary diagnosis of pneumonia paired with a principal diagnosis of sepsis or respiratory failur...
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Preintubation Sequential Organ Failure Assessment Score for Predicting COVID-19 Mortality: External Validation Using Electronic Health Record From 86 U.S. Healthcare Systems to Appraise Current Ventilator Triage Algorithms*
CONCLUSIONS: In a U.S. cohort of over 15,000 ventilated patients with COVID-19, the SOFA score displayed poor predictive accuracy for short-term mortality. Our findings warrant reappraisal of the SOFA score’s implementation and weightage in existing ventilator triage pathways in current U.S. crisis standards of care guidelines. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

The Global Open Source Severity of Illness Score (GOSSIS)*
CONCLUSIONS: GOSSIS-1 is a modern, free, open-source inhospital mortality prediction algorithm for critical care patients, achieving excellent discrimination and calibration across three countries. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Society of Critical Care Medicine Presidential Address–51st Annual Congress, April 2022
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Presidential Address Source Type: research

Immune Profiling Demonstrates a Common Immune Signature of Delayed Acquired Immunodeficiency in Patients With Various Etiologies of Severe Injury: Erratum
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Erratum Source Type: research

The Fundamentals of Hysteresis and Lung Recruitment in Patients With Acute Respiratory Distress Syndrome
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Sepsis and Resuscitation: The Importance of Time
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Effects of Moderate Hypothermia on Diastolic Functions of Heart
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Wacker et al, Who Conclude That Vitamin C Monotherapy Failed to Significantly Reduce Mortality in Septic Shock Patients: Beware of Potential Confounding Factors!
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Benzodiazepine-Based Sedation Did Not Add an Independent Risk of Delirium?
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research