Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
CONCLUSIONS: We found aberrant fibrin clot structure and function in critically ill patients with COVID-19. These findings may contribute to the poor outcomes observed in COVID-19 patients with widespread fibrin deposition. (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Does Unprecedented ICU Capacity Strain, As Experienced During the COVID-19 Pandemic, Impact Patient Outcome?
CONCLUSIONS: For patients admitted to ICU during the pandemic, unprecedented levels of ICU capacity strain were significantly associated with higher acute hospital mortality, after accounting for differences in baseline characteristics. Further study into possible differences in the provision of care and outcome for COVID-19 and non-COVID-19 patients is needed. (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Factors Associated With Brain Tissue Oxygenation Changes After RBC Transfusion in Acute Brain Injury Patients
CONCLUSIONS: Lower PbtO2 values and high HR at baseline could predict a significant increase in brain oxygenation after RBCT. (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome
CONCLUSIONS: This retrospective multicenter analysis showed a six-fold increased adjusted risk for ICH and a 3.5-fold increased incidence of ICH in COVID-19 patients on ECMO. Prospective studies are needed to confirm this observation and to determine whether the bleeding risk can be reduced by adjusting anticoagulation strategies. (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Brain Biopsy for Neurological Diseases of Unknown Etiology in Critically Ill Patients: Feasibility, Safety, and Diagnostic Yield
CONCLUSIONS: Brain biopsy in critically ill patients with neurologic disease of unknown etiology is associated with high diagnostic yield, therapeutic modifications and postbiopsy survival advantage. Safety profile seems acceptable in most patients. The benefit/risk ratio of brain biopsy in this population should be carefully weighted. (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance
This study aims to determine if pathologic mitochondrial fission mediated by Drp1/Fis1 interaction impacts extracellular mitochondrial content and macrophage function in sepsis-induced immunoparalysis. DESIGN: Laboratory investigation. SETTING: University laboratory. SUBJECTS: C57BL/6 and BALB/C mice. INTERVENTIONS: Using in vitro and murine models of endotoxin tolerance (ET), we evaluated changes in Drp1/Fis1-dependent pathologic fission and simultaneously measured the quantity and quality of extracellular mitochondria. Next, by priming mouse macrophages with isolated healthy mitochondria (MC) ...
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Seventeen Years Is Too Long to Move From the ICU to the Emergency Department*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

After a Heart Attack, Who Should Care?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Is This the Beginning of the End of Cytokine Adsorption?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Frailty and Disability: Predictors or Outcomes or Both in Post COVID-19*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

COVID-19, Critical Illness, and Sleep*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Metformin: An Intriguing Protective Agent in Hospitalized Diabetic Patients With Sepsis*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

From Syphilis to Sepsis: Pilot Studies and the Importance of Staying Grounded*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

A Tale of Two ICUs: One for Women and One for Men?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

MEDucation: Healthcare Providers, Educators, and Families Partnering to Address the Educational Challenges of Children After Recovery From Critical Illness*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - May 27, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research