The authors reply
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

Coronavirus Disease 2019 Tracheostomy Candidacy, Ceteris Paribus Assumptions, and Tracking Survivorship Data
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Letters To The Editor Source Type: research

Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis
CONCLUSIONS: Extended-use high-dose IV tranexamic acid does not improve mortality or bleeding outcomes and increases adverse events. Low-dose/enteral tranexamic acid may be effective in reducing hemorrhage; more evidence is required to demonstrate its safety. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Review Articles Source Type: research

IV Vitamin C in Critically Ill Patients: A Systematic Review and Meta-Analysis
CONCLUSIONS: IV vitamin C administration appears safe and may be associated with a trend toward reduction in overall mortality. High-dose IV vitamin C monotherapy may be associated with improved overall mortality, and further randomized controlled trials are warranted. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Review Articles Source Type: research

Neuromuscular Blocker Use in Critically Ill Children: Assessing Mortality Risk by Propensity Score–Weighted Analysis
OBJECTIVES: We aim to describe the use of continuous infusion of neuromuscular blocking agents in mechanically ventilated critically ill children and to test its association with in-hospital mortality. DESIGN: Multicenter, registry-based, observational, two-cohort-comparison retrospective study using prospectively collected data from a web-based national registry. SETTING: Seventeen PICUs in Italy. PATIENTS: We included children less than 18 years who received mechanical ventilation and a neuromuscular blocking agent infusion from January 2010 to October 2017. A propensity score–weighted Cox regr...
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness
OBJECTIVES: Multiple organ failure in critically ill patients is associated with poor prognosis, but biomarkers contributory to pathogenesis are unknown. Previous studies support a role for Fas cell surface death receptor (Fas)-mediated apoptosis in organ dysfunction. Our objectives were to test for associations between soluble Fas and multiple organ failure, identify protein quantitative trait loci, and determine associations between genetic variants and multiple organ failure. DESIGN: Retrospective observational cohort study. SETTING: Four academic ICUs at U.S. hospitals. PATIENTS: Genetic analys...
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Peripheral Oxygen Saturation Facilitates Assessment of Respiratory Dysfunction in the Sequential Organ Failure Assessment Score With Implications for the Sepsis-3 Criteria
OBJECTIVES: Sequential Organ Failure Assessment score is the basis of the Sepsis-3 criteria and requires arterial blood gas analysis to assess respiratory function. Peripheral oxygen saturation is a noninvasive alternative but is not included in neither Sequential Organ Failure Assessment score nor Sepsis-3. We aimed to assess the association between worst peripheral oxygen saturation during onset of suspected infection and mortality. DESIGN: Cohort study of hospital admissions from a main cohort and emergency department visits from four external validation cohorts between year 2011 and 2018. Data were collected...
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Association Between Urine Output and Mortality in Critically Ill Patients: A Machine Learning Approach
CONCLUSIONS: Consistent with current definitions of acute kidney injury, a urine output threshold of less than 0.5 mL/kg/hr is modestly predictive of mortality in patients admitted to the ICU. The relative importance of urine output for predicting survival varies with admission diagnosis. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

The Effectiveness of High-Flow Nasal Cannula in Coronavirus Disease 2019 Pneumonia: A Retrospective Cohort Study
CONCLUSIONS: Among unselected patients with severe coronavirus disease 2019 pneumonia, high-flow nasal cannula was not associated with a statistically significant reduction in hazard of death. However, in patients not mechanically ventilated within 6 hours of admission, high-flow nasal cannula was associated with a significantly reduced hazard of death. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Postmortem Evidence of Brain Inflammatory Markers and Injury in Septic Patients: A Systematic Review
CONCLUSIONS: The mechanisms by which sepsis induces brain dysfunction are likely to include vascular and neuronal lesions, followed by the activation of glial cells and the presence of peripheral immune cells in the brain. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Electrical Impedance Tomography Monitoring of Bronchoalveolar Lavage in Patients With Acute Respiratory Distress Syndrome
CONCLUSIONS: The negative impact of bronchoalveolar lavage on regional ventilation, which persisted at least 6 hours, appeared to be more profound in patients with normal lung function or mild acute respiratory distress syndrome. In contrast, regional ventilation, lung recruitment, respiratory mechanics, and gas exchanges were modestly impacted by the bronchoalveolar lavage in patients with severe or moderate acute respiratory distress syndrome. That finding is reassuring and supports not summarily proscribing bronchoalveolar lavage for the most severely ill with acute respiratory distress syndrome. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Pathophysiologic Signature of Impending ICU Hypoglycemia in Bedside Monitoring and Electronic Health Record Data: Model Development and External Validation
CONCLUSIONS: We used data from a large number of critically ill inpatients to develop and externally validate a predictive model of impending ICU hypoglycemia. Future steps include incorporating this model into a clinical decision support system and testing its effects in a multicenter randomized controlled clinical trial. (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Bursting at the Seams: Barotrauma in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

Why Clinicians Should Adopt Routine Neuroimaging After Extracorporeal Membrane Oxygenation*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research

The IMPACT of Transitional Care Management in Sepsis*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - February 23, 2022 Category: Emergency Medicine Tags: Editorials Source Type: research