Clinical Reviews in Bone and Mineral Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Physiology of Mechanotransduction: How Do Muscle and Bone “Talk” to One Another?
Abstract The complexity of cell interactions with their microenvironment and their ability to communicate at the autocrine, paracrine, and endocrine levels has gradually but significantly evolved in the last three decades. The musculoskeletal system has been historically recognized to be governed by a relationship of proximity and function, chiefly dictated by mechanical forces and the work of gravity itself. In this review article, we first provide a historical overview of the biomechanical theory of bone–muscle interactions. Next, we expand to detail the significant evolution in our understanding of...
Source: Clinical Reviews in Bone and Mineral Metabolism - June 1, 2014 Category: Internal Medicine Source Type: research

The Influence of Muscular Action on Bone Strength Via Exercise
Abstract Mechanical stimuli influence bone strength, with internal muscular forces thought to be the greatest stressors of bone. Consequently, the effects of exercise in improving and maintaining bone strength have been explored in a number of interventional studies. These studies demonstrate a positive effect of high-impact activities (i.e. where large muscle forces are produced) on bone strength, with benefits being most pronounced in interventions in early pubertal children. However, current studies have not investigated the forces acting on bones and subsequent deformation, preventing the developmen...
Source: Clinical Reviews in Bone and Mineral Metabolism - June 1, 2014 Category: Internal Medicine Source Type: research

Clinical Outcomes of Impaired Muscle and Bone Interactions
Abstract Muscle and bone are in constant interaction. With aging, there is a progressive decline in muscle mass, known as sarcopenia, as well as in bone mass, which is known as osteopenia/osteoporosis. Sarcopenia and osteoporosis increase the risk of suffering falls and fractures, respectively. In fact, the simultaneous occurrence of osteoporosis and sarcopenia has been observed in a subset of frailer individuals at higher risk of disability, falls and fractures. However, the particular clinical outcomes that are unique to the sarco-osteoporotic patients remain unknown. In this review, we propose a comm...
Source: Clinical Reviews in Bone and Mineral Metabolism - June 1, 2014 Category: Internal Medicine Source Type: research

Bone and Muscle Pleiotropy: The Genetics of Associated Traits
Abstract Bone and muscle mass are highly correlated. In part, this is a consequence of both tissues sharing common genetic determinants. In addition, both tissues are responsive to their mechanical environments. New genetic tools in mice will allow genes of interest to be inactivated in experimentally defined contexts, thus allowing investigators to distinguish direct effects on each tissue from physiological responses to a primary phenotype in the other. (Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - June 1, 2014 Category: Internal Medicine Source Type: research

Past, Present and Future of Muscle–Bone Interactions
(Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - June 1, 2014 Category: Internal Medicine Source Type: research

100 Years of Weight Loss Surgery: Voluntary Weight Loss, Involuntary Bone Loss
This article endeavors to do exactly that. Intestinal bypass surgeries to treat obesity are here to stay. Some of the most profound complications of intestinal bypass manifest in the skeleton and include skeletal demineralization, hyperoxaluria, nephrolithiasis, and fractures. Much has been done to further elucidate the underlying mechanisms, identify preventive strategies, and implement practice guidelines, but this patient population remains at increased risk for metabolic bone disease. (Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - April 2, 2014 Category: Internal Medicine Source Type: research

Bariatric Surgery and Bone Loss: Do We Need to Be Concerned?
Abstract Despite significant improvement in weight and comorbid conditions, there is growing evidence that bariatric surgery may exert a negative effect on the skeleton. This review has focused on the impact of bariatric surgery on bone health, with the concern that bariatric surgery may increase skeletal fragility and fracture risk by accelerating bone loss. We have highlighted studies evaluating changes in bone metabolism after three commonly performed bariatric procedures including laparoscopic adjustable gastric banding, Roux-en-Y gastric bypass surgery and increasingly popular sleeve gastrectomy. Thi...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 13, 2014 Category: Internal Medicine Source Type: research

Biochemical Interaction Between Muscle and Bone: A Physiological Reality?
Abstract In elderly with a sedentary lifestyle, often suffering from sarcopenia to osteopenia, a training intervention could be an effective countermeasure for bone as well as muscle. Both bone and muscle adapt their mass and strength in response to mechanical loading in part via similar signaling pathways. Bone as well as muscle produces a wide variety of growth factors and cytokines in response to mechanical loading, which are important for their adaptations. It has been hypothesized that in addition to mechanical stimuli, muscle and bone communicate by these factors. Whether such biochemical interact...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2014 Category: Internal Medicine Source Type: research

Osteocyte Communication with the Kidney Via the Production of FGF23: Remote Control of Phosphate Homeostasis
Abstract Osteocytes have emerged as the principal controlling cell type in bone. It is now clear that osteocytes communicate with each other, with other key bone cell types and also function as a vital endocrine organ. In this review, we will focus on one such humoral factor produced by osteocytes, fibroblast growth factor 23 and the involvement of this key phosphate-regulating hormone in human disease. (Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2014 Category: Internal Medicine Source Type: research

General Introduction
(Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2014 Category: Internal Medicine Source Type: research