Bone and Muscle Pleiotropy: The Genetics of Associated Traits

Abstract Bone and muscle mass are highly correlated. In part, this is a consequence of both tissues sharing common genetic determinants. In addition, both tissues are responsive to their mechanical environments. New genetic tools in mice will allow genes of interest to be inactivated in experimentally defined contexts, thus allowing investigators to distinguish direct effects on each tissue from physiological responses to a primary phenotype in the other.
Source: Clinical Reviews in Bone and Mineral Metabolism - Category: Internal Medicine Source Type: research