Clinical Reviews in Bone and Mineral Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vitamin D Status in the North African Population: a Review
The objectives of the present review are to summarize the existing literature on vitamin D status and to list the main predictors of hypovitaminosis D in North African population. We searched Medline/PubMed, Cochrane, CINAHL, Embase, Scopus, and Springerlink for the published data on vitamin D in North African countries. The identified articles had to meet all the following criteria: human clinical outcomes rather than animal experiments, a cross-sectional or longitudinal study and quantitative information on vitamin D status in North Africa must be included. Several studies proved a high prevalence of hypovitaminosis D in...
Source: Clinical Reviews in Bone and Mineral Metabolism - September 1, 2018 Category: Internal Medicine Source Type: research

Bringing Attention to Lesser-known Bone Remodeling Pathways
AbstractOsteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer and, by 2025, the number of fractures due to osteoporosis is expected to rise to nearly three million in the USA alone. Pharmacological treatments for osteoporosis are aimed at stabilizing or increasing bone mass. However, there are significant drawbacks to current pharmacological options, particularly for long-term management of this chronic condition. Moreover, the drug development pipelin...
Source: Clinical Reviews in Bone and Mineral Metabolism - September 1, 2018 Category: Internal Medicine Source Type: research

Association Between Social Support and Bone Health Outcomes: a Systematic Review
AbstractPrevious studies on the association between social support and bone health outcomes did not produce consistent results. The main goal of this study was to resolve the inconsistency by systematically examining the studies on the association in the last two decades. In order to do that, we distinguished between two types of social supports: structural supports, which is the pattern of person ’s social relationship, and functional support, which is the perceived specific functions from social ties. For fracture, structural social support, especially marital (or cohabitation) status, showed a strong association betwe...
Source: Clinical Reviews in Bone and Mineral Metabolism - August 17, 2018 Category: Internal Medicine Source Type: research

Vitamin D Status in the North African Population: a Review
The objectives of the present review are to summarize the existing literature on vitamin D status and to list the main predictors of hypovitaminosis D in North African population. We searched Medline/PubMed, Cochrane, CINAHL, Embase, Scopus, and Springerlink for the published data on vitamin D in North African countries. The identified articles had to meet all the following criteria: human clinical outcomes rather than animal experiments, a cross-sectional or longitudinal study and quantitative information on vitamin D status in North Africa must be included. Several studies proved a high prevalence of hypovitaminosis D in...
Source: Clinical Reviews in Bone and Mineral Metabolism - July 6, 2018 Category: Internal Medicine Source Type: research

Skeletal Effects of Thyroid Hormones
AbstractThe importance of functional thyroid abnormalities can hardly be overstated as they affect over 5% of the population. Thyroid hormones exert a multitude of effects on the metabolism of both the developing and the adult skeleton. It is thus unsurprising that changes in thyroid function can have a variety of often severe skeletal consequences. In recent years, numerous advances were made in the understanding of this domain. These include for instance the mapping of different pathways mediating genomic and nongenomic actions of thyroid hormones in osteoblasts and osteoclasts, or the investigation of the direct role of...
Source: Clinical Reviews in Bone and Mineral Metabolism - June 1, 2018 Category: Internal Medicine Source Type: research

Testosterone and Male Osteoporosis
AbstractMale osteoporosis is not a rare public health issue. The prevalence of hypogonadism increases with aging, and the gradual onset of moderate hypogonadism is the most common cause of male osteoporosis. Decreased testosterone levels with aging can directly or indirectly increase the risk of male osteoporosis and fractures. However, testosterone deficiency is not a universal feature of elderly men, and the association of testosterone with osteoporosis is not as strong as that of estrogen with osteoporosis in females; the effect of testosterone on male osteoporosis and treatment of osteoporosis is still controversial. A...
Source: Clinical Reviews in Bone and Mineral Metabolism - June 1, 2018 Category: Internal Medicine Source Type: research

Skeletal Effects of Thyroid Hormones
AbstractThe importance of functional thyroid abnormalities can hardly be overstated as they affect over 5% of the population. Thyroid hormones exert a multitude of effects on the metabolism of both the developing and the adult skeleton. It is thus unsurprising that changes in thyroid function can have a variety of often severe skeletal consequences. In recent years, numerous advances were made in the understanding of this domain. These include for instance the mapping of different pathways mediating genomic and nongenomic actions of thyroid hormones in osteoblasts and osteoclasts, or the investigation of the direct role of...
Source: Clinical Reviews in Bone and Mineral Metabolism - April 24, 2018 Category: Internal Medicine Source Type: research

Testosterone and Male Osteoporosis
AbstractMale osteoporosis is not a rare public health issue. The prevalence of hypogonadism increases with aging, and the gradual onset of moderate hypogonadism is the most common cause of male osteoporosis. Decreased testosterone levels with aging can directly or indirectly increase the risk of male osteoporosis and fractures. However, testosterone deficiency is not a universal feature of elderly men, and the association of testosterone with osteoporosis is not as strong as that of estrogen with osteoporosis in females; the effect of testosterone on male osteoporosis and treatment of osteoporosis is still controversial. A...
Source: Clinical Reviews in Bone and Mineral Metabolism - April 12, 2018 Category: Internal Medicine Source Type: research

Glucocorticoid Excess in Bone and Muscle
AbstractGlucocorticoids (GC), produced and released by the adrenal glands, regulate numerous physiological processes in a wide range of tissues. Because of their profound immunosuppressive and anti-inflammatory actions, GC are extensively used for the treatment of immune and inflammatory conditions, the management of organ transplantation, and as a component of chemotherapy regimens for cancers. However, both pathologic endogenous elevation and long-term use of exogenous GC are associated with severe adverse effects. In particular, excess GC has devastating effects on the musculoskeletal system. GC increase bone resorption...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2018 Category: Internal Medicine Source Type: research

Stress and Insufficiency Fractures
AbstractStress fractures are most common in athletes and military recruits but also occur in patients with underlying metabolic bone disease (insufficiency fractures). Stress fractures are most frequent in the lower extremities and more common in women. Thefemale athlete triad is an important risk factor. At the cellular level, the osteocyte may be important in the detection of stress fractures. Further, osteocytes are probably important in the healing of stress fractures. In patients with recurrent stress fractures, a biochemical evaluation for underlying metabolic bone disease should be undertaken. Prevention includes av...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2018 Category: Internal Medicine Source Type: research

Myokine —Irisin—and Its Effects Linking Bone and Muscle Function
AbstractIrisin is a myokine secreted by the skeletal muscle during physical activity both in mice and humans. Its first identified role was to activate the browning response in white adipocytes, subsequently triggering non-shivering thermogenesis; therefore, Irisin has raised great expectations as a potential target in the treatment of obesity. In 2015, we demonstrated that Irisin plays a central role in the control of bone mass, driving positive effects on cortical mineral density and bone mechanical properties. This effect on the bone was triggered using an Irisin dosage 70 times lower than the one needed to induce the b...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2018 Category: Internal Medicine Source Type: research

2018 —Changing Times for CRBM
(Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2018 Category: Internal Medicine Source Type: research

Effects of Bazedoxifene on Bone Mineral Density and Fracture in Post-Menopausal Osteoporotic Women: a Systematic Review and Meta-Analysis
AbstractBazedoxifene (BZA) is a selective estrogen receptor modulator that reduces the risk of fracture and improves bone mineral density in post-menopausal women with osteoporosis. The aim of the present systematic review and meta-analysis was to investigate effects of BZA on bone mineral density (BMD) and fracture in post-menopausal osteoporotic women. We searched PubMed, Cochrane Central Register of Controlled Trials, Web of Sciences, Embase, and Scopus from until November 30, 2016. All randomized controlled trials that compared the effects of BZA on BMD and the incidence of vertebral and non-vertebral fractures in post...
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2018 Category: Internal Medicine Source Type: research

Acknowledgement for Reviewers 2017
(Source: Clinical Reviews in Bone and Mineral Metabolism)
Source: Clinical Reviews in Bone and Mineral Metabolism - March 1, 2018 Category: Internal Medicine Source Type: research