The profile of cholesterol metabolism does not interfere with the cholesterol-lowering efficacy of phytostanol esters
Increasing evidence suggests that high cholesterol absorption efficiency enhances the risk of atherosclerotic cardiovascular diseases. It is not known whether inhibiting cholesterol absorption has different metabolic effects in high- vs. low cholesterol absorbers. We evaluated the effects of phytostanol esters on serum lipids and cholesterol metabolism in a post hoc study of three randomized, double-blind, controlled trials. The participants were classified into low (n=20) and high (n=21) cholesterol absorbers by median cholesterol absorption efficiency based on the plasma cholesterol absorption marker cholestanol at basel...
Source: Clinical Nutrition - January 19, 2024 Category: Nutrition Authors: Helena Gylling, Katariina Öörni, Lotta Nylund, Ingmar Wester, Piia Simonen Tags: Original article Source Type: research
Comment on: ” Impact of a specialized oral nutritional supplement on quality of life in older adults following hospitalization: Post-hoc analysis of the NOURISH trial”
(Source: Clinical Nutrition)
Source: Clinical Nutrition - January 19, 2024 Category: Nutrition Authors: Xi Yin Yang, Qiang Hu Tags: Letter to the Editor Source Type: research
Reply - Letter to the editor "The egg and the chicken: does sarcopenia or cognitive impairment come first?"
(Source: Clinical Nutrition)
Source: Clinical Nutrition - January 19, 2024 Category: Nutrition Authors: Shuyue Tuo, Zhang Wen, Qiuju Ran, Shejiao Dai, Jinhai Wang, Xinxing Tantai Tags: Letter to the Editor Source Type: research
Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus
The hypothalamus is a crucial brain region that mediates the effects of insulin and leptin signals on peripheral metabolic functions. Previous research has shown that insulin signals in the hypothalamus act via multiple neuronal circuits and anabolic/catabolic pathways that converge on the vagus nerve and sympathetic fibers to coordinate energy metabolism in peripheral organs. Additionally, neuropeptide FF (NPFF) has been identified as a regulator of feeding behaviors and energy homeostasis in the hypothalamus, but the mechanisms underlying its involvement in metabolic control remain unclear. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 17, 2024 Category: Nutrition Authors: Ya-Tin Lin, Kuan-Hsuan Wu, Jie-Jhu Jhang, Jie-Lan Jhang, Zachary Yu, Sze-Chi Tsai, Jin-Chung Chen, Po-Hung Hsu, Hui-Yun Li Tags: Original article Source Type: research
Poorly Controlled Glycemia and Worse Beta Cell Function Associate with Higher Resting and Total Energy Expenditure in Adults with Obesity and Type 2 Diabetes: A Doubly Labeled Water Study
Some studies comparing persons with and without type 2 diabetes (T2DM) show no difference in resting energy expenditure (REE). However, the degree of glycemic control may be a crucial factor in determining energy requirements. Few studies have employed the doubly labeled water (DLW) method in persons with T2DM to objectively measure daily energy expenditure. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 17, 2024 Category: Nutrition Authors: Kate Lillegard, John A. Del Castillo, Heidi J. Silver Tags: Original article Source Type: research
The Impact of 5-Hydroxytryptophan Supplementation on Sleep Quality and Gut Microbiota Composition in Older Adults: A Randomized Controlled Trial
Sleep quality is a pivotal part of health and there is growing evidence on the association between gut microbiota composition and sleep quality. 5-Hydroxytryptophan (5-HTP) is known as a precursor of the sleep regulating neurotransmitter and hormone however, efficacy of 5-HTP supplementation for improving sleep quality in older adults is unclear. Hence, the aim of this study is to assess the impact of 5-HTP supplementation on sleep quality and gut microbiota composition in older adults. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 16, 2024 Category: Nutrition Authors: Clarinda Nataria Sutanto, Xuejuan Xia, Chin Wee Heng, Yue Shuian Tan, Delia Pei Shan Lee, Johnson Fam, Jung Eun Kim Tags: Randomized Control Trials Source Type: research
Addressing cancer anorexia-cachexia in older patients: potential therapeutic strategies and molecular pathways
Cancer cachexia (CC) syndrome, a feature of cancer-associated muscle wasting, is particularly pronounced in older patients, and is characterised by decreased energy intake and upregulated skeletal muscle catabolic pathways. To address CC, appetite stimulants, anabolic drugs, cytokine mediators, essential amino acid supplementation, nutritional counselling, cognitive behavioural therapy, and enteral nutrition have been utilised. However, pharmacological treatments that have also shown promising results, such as megestrol acetate, anamorelin, thalidomide, and delta-9-tetrahydrocannabinol, have been associated with gastrointe...
Source: Clinical Nutrition - January 11, 2024 Category: Nutrition Authors: Theocharis Ispoglou, Deaglan McCullough, Angela Windle, Sherena Nair, Natalie Cox, Helen White, Dermot Burke, Anastasios Kanatas, Konstantinos Prokopidis Tags: Narrative Review Source Type: research
Plasma and red blood cell concentrations of zinc, copper, selenium and magnesium in the first week of paediatric critical illness
This study longitudinally examined micronutrient concentrations in both plasma and RBC in critically ill children. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 9, 2024 Category: Nutrition Authors: K. Veldscholte, M. Al Fify, A. Catchpole, D. Talwar, J. Wadsworth, I. Vanhorebeek, M.P. Casaer, G. Van den Berghe, K.F.M. Joosten, K. Gerasimidis, S.C.A.T. Verbruggen Tags: Original article Source Type: research
Various Types of Fasting Diet and Possible Benefits in Nonalcoholic Fatty Liver: Mechanism of Actions and Literature Update
Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver injury, affecting around one-fourth of the general population across the world. Several important pathophysiological mechanisms underlying NAFLD include oxidative stress, inflammation, liver fibrosis, and apoptosis. Currently, therapeutic approaches are not ideal for managing NAFLD, thus new approaches and treatments are still needed. Over the last two decades, various fasting protocols have been explored to reduce body weight and improve metabolic disorders. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 9, 2024 Category: Nutrition Authors: Zahra Sadat Mirrazavi, Vahideh Behrouz Tags: Narrative Review Source Type: research
Elevated 18F-FDG uptake in Subcutaneous Adipose Tissue Correlates Negatively with Nutritional Status and Prognostic Survival in Cachexia Patients with Gastric Cancer
Browning of white adipose tissue is a crucial factor contributing to adipose loss in cachexia patients, detectable via 18F-Fluorodeoxyglucose (18F-FDG) uptake. The present study elucidates the clinical relevance of 18F-FDG uptake in the subcutaneous adipose tissue of gastric cancer patients, specifically focusing on adipose browning and its implications on patient clinical parameters and prognosis. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 8, 2024 Category: Nutrition Authors: Diya Sun, Hongyan Yin, Xiao Liu, Zuoyou Ding, Lei Shen, Szechun Sah, Jun Han, Guohao Wu Tags: Original article Source Type: research
The relation of dietary protein intake before and during the pregnancy with gestational diabetes mellitus (GDM): A GRADE-assessed systematic review and dose-response meta-analysis of epidemiologic studies
Although previous studies investigated the relation of protein intake and gestational diabetes mellitus (GDM), their findings were controversial. Therefore, we aimed to summarize this association, through a comprehensive systematic review and dose-response meta-analysis. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 8, 2024 Category: Nutrition Authors: Zahra Hajhashemy, Mohammad Bagherniya, Omid Sadeghi, Gholamreza Askari Tags: Meta-analyses Source Type: research
Red blood cell distribution width (RDW) – a new nutritional biomarker to assess nutritional risk and response to nutritional therapy?
Red cell distribution width (RDW) has been proposed as a surrogate marker for acute and chronic diseases and may be influenced by nutritional deficits. We assessed the prognostic value of RDW regarding clinical outcomes and nutritional treatment response among medical inpatients at nutritional risk. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 5, 2024 Category: Nutrition Authors: Eliane Haenggi, Nina Kaegi-Braun, Carla Wunderle, Pascal Tribolet, Beat Mueller, Zeno Stanga, Philipp Schuetz Tags: Randomized Control Trials Source Type: research
Letter to the editor: The association between human milk fatty acid composition in mothers with an elevated body mass index and infant growth changes
(Source: Clinical Nutrition)
Source: Clinical Nutrition - January 5, 2024 Category: Nutrition Authors: Karollainy Gomes da Silva, Maria Eduarda Rodrigues Alves dos Santos, Erica Helena Alves da Silva, Sandra Lopes de Souza, Waleska Maria Almeida Barros Tags: Letter to the Editor Source Type: research
Frailty modifies the association of body mass index with mortality among older adults: Kyoto-Kameoka study
This study investigated this association in community-dwelling older adults with and without frailty. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 4, 2024 Category: Nutrition Authors: Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura Tags: Original article Source Type: research
The association between prepregnancy dietary fatty acids and risk of gestational diabetes mellitus: A prospective cohort study
This study aimed to evaluate prepregnancy fatty acids intake in relation to GDM risk. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 1, 2024 Category: Nutrition Authors: Yahui Fan, Zhaofang Li, Jia Shi, Sijiao Liu, Lintian Li, Lu Ding, Jinping Zhao, Yunjin Pan, Haoyuan Lei, Tongqiang He, Weiling Li, Xuelan Li, Yang Mi, Le Ma Tags: Original article Source Type: research
