Invasive fusariosis
Clin Microbiol Rev. 2023 Nov 8:e0015922. doi: 10.1128/cmr.00159-22. Online ahead of print.ABSTRACTSUMMARYInvasive fusariosis is a serious invasive fungal disease, affecting immunocompetent and, more frequently, immunocompromised patients. Localized disease is the typical clinical form in immunocompetent patients. Immunocompromised hosts at elevated risk of developing invasive fusariosis are patients with acute leukemia receiving chemotherapeutic regimens for remission induction, and those undergoing allogeneic hematopoietic cell transplant. In this setting, the infection is usually disseminated with positive blood cultures...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Marcio Nucci Elias Anaissie Source Type: research
< em > Klebsiella pneumoniae < /em > carbapenemase variants: the new threat to global public health
Clin Microbiol Rev. 2023 Nov 8:e0000823. doi: 10.1128/cmr.00008-23. Online ahead of print.ABSTRACTSUMMARYKlebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution, insertion, or deletion of amino acid sequence compared to wild blaKPC type, have reduced utility of ceftazidime-avibactam (CZA), a pioneer antimicrobial agent in treating carbapenem-resistant Enterobacterales infections. So far, more than 150 blaKPC variants have been reported worldwide, and most of the new variants were discovered in the past 3 years, which calls for public alarm. The KPC variant protein enhances the affinity to ceftaz...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Li Ding Siquan Shen Jing Chen Zhen Tian Qingyu Shi Renru Han Yan Guo Fupin Hu Source Type: research
Human strongyloidiasis: complexities and pathways forward
Clin Microbiol Rev. 2023 Nov 8:e0003323. doi: 10.1128/cmr.00033-23. Online ahead of print.ABSTRACTSUMMARYStrongyloidiasis is a World Health Organization neglected tropical disease usually caused by Strongyloides stercoralis, a parasitic worm with a complex life cycle. Globally, 300-600 million people are infected through contact with fecally contaminated soil. An autoinfective component of the life cycle can lead to chronic infection that may be asymptomatic or cause long-term symptoms, including malnourishment in children. Low larval output can limit the sensitivity of detection in stool, with serology being effective but...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Dora Buonfrate Richard S Bradbury Matthew R Watts Zeno Bisoffi Source Type: research
Invasive fusariosis
Clin Microbiol Rev. 2023 Nov 8:e0015922. doi: 10.1128/cmr.00159-22. Online ahead of print.ABSTRACTSUMMARYInvasive fusariosis is a serious invasive fungal disease, affecting immunocompetent and, more frequently, immunocompromised patients. Localized disease is the typical clinical form in immunocompetent patients. Immunocompromised hosts at elevated risk of developing invasive fusariosis are patients with acute leukemia receiving chemotherapeutic regimens for remission induction, and those undergoing allogeneic hematopoietic cell transplant. In this setting, the infection is usually disseminated with positive blood cultures...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Marcio Nucci Elias Anaissie Source Type: research
< em > Klebsiella pneumoniae < /em > carbapenemase variants: the new threat to global public health
Clin Microbiol Rev. 2023 Nov 8:e0000823. doi: 10.1128/cmr.00008-23. Online ahead of print.ABSTRACTSUMMARYKlebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution, insertion, or deletion of amino acid sequence compared to wild blaKPC type, have reduced utility of ceftazidime-avibactam (CZA), a pioneer antimicrobial agent in treating carbapenem-resistant Enterobacterales infections. So far, more than 150 blaKPC variants have been reported worldwide, and most of the new variants were discovered in the past 3 years, which calls for public alarm. The KPC variant protein enhances the affinity to ceftaz...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Li Ding Siquan Shen Jing Chen Zhen Tian Qingyu Shi Renru Han Yan Guo Fupin Hu Source Type: research
Human strongyloidiasis: complexities and pathways forward
Clin Microbiol Rev. 2023 Nov 8:e0003323. doi: 10.1128/cmr.00033-23. Online ahead of print.ABSTRACTSUMMARYStrongyloidiasis is a World Health Organization neglected tropical disease usually caused by Strongyloides stercoralis, a parasitic worm with a complex life cycle. Globally, 300-600 million people are infected through contact with fecally contaminated soil. An autoinfective component of the life cycle can lead to chronic infection that may be asymptomatic or cause long-term symptoms, including malnourishment in children. Low larval output can limit the sensitivity of detection in stool, with serology being effective but...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Dora Buonfrate Richard S Bradbury Matthew R Watts Zeno Bisoffi Source Type: research
Invasive fusariosis
Clin Microbiol Rev. 2023 Nov 8:e0015922. doi: 10.1128/cmr.00159-22. Online ahead of print.ABSTRACTSUMMARYInvasive fusariosis is a serious invasive fungal disease, affecting immunocompetent and, more frequently, immunocompromised patients. Localized disease is the typical clinical form in immunocompetent patients. Immunocompromised hosts at elevated risk of developing invasive fusariosis are patients with acute leukemia receiving chemotherapeutic regimens for remission induction, and those undergoing allogeneic hematopoietic cell transplant. In this setting, the infection is usually disseminated with positive blood cultures...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Marcio Nucci Elias Anaissie Source Type: research
< em > Klebsiella pneumoniae < /em > carbapenemase variants: the new threat to global public health
Clin Microbiol Rev. 2023 Nov 8:e0000823. doi: 10.1128/cmr.00008-23. Online ahead of print.ABSTRACTSUMMARYKlebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution, insertion, or deletion of amino acid sequence compared to wild blaKPC type, have reduced utility of ceftazidime-avibactam (CZA), a pioneer antimicrobial agent in treating carbapenem-resistant Enterobacterales infections. So far, more than 150 blaKPC variants have been reported worldwide, and most of the new variants were discovered in the past 3 years, which calls for public alarm. The KPC variant protein enhances the affinity to ceftaz...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Li Ding Siquan Shen Jing Chen Zhen Tian Qingyu Shi Renru Han Yan Guo Fupin Hu Source Type: research
Human strongyloidiasis: complexities and pathways forward
Clin Microbiol Rev. 2023 Nov 8:e0003323. doi: 10.1128/cmr.00033-23. Online ahead of print.ABSTRACTSUMMARYStrongyloidiasis is a World Health Organization neglected tropical disease usually caused by Strongyloides stercoralis, a parasitic worm with a complex life cycle. Globally, 300-600 million people are infected through contact with fecally contaminated soil. An autoinfective component of the life cycle can lead to chronic infection that may be asymptomatic or cause long-term symptoms, including malnourishment in children. Low larval output can limit the sensitivity of detection in stool, with serology being effective but...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Dora Buonfrate Richard S Bradbury Matthew R Watts Zeno Bisoffi Source Type: research
Invasive fusariosis
Clin Microbiol Rev. 2023 Nov 8:e0015922. doi: 10.1128/cmr.00159-22. Online ahead of print.ABSTRACTSUMMARYInvasive fusariosis is a serious invasive fungal disease, affecting immunocompetent and, more frequently, immunocompromised patients. Localized disease is the typical clinical form in immunocompetent patients. Immunocompromised hosts at elevated risk of developing invasive fusariosis are patients with acute leukemia receiving chemotherapeutic regimens for remission induction, and those undergoing allogeneic hematopoietic cell transplant. In this setting, the infection is usually disseminated with positive blood cultures...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Marcio Nucci Elias Anaissie Source Type: research
< em > Klebsiella pneumoniae < /em > carbapenemase variants: the new threat to global public health
Clin Microbiol Rev. 2023 Nov 8:e0000823. doi: 10.1128/cmr.00008-23. Online ahead of print.ABSTRACTSUMMARYKlebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution, insertion, or deletion of amino acid sequence compared to wild blaKPC type, have reduced utility of ceftazidime-avibactam (CZA), a pioneer antimicrobial agent in treating carbapenem-resistant Enterobacterales infections. So far, more than 150 blaKPC variants have been reported worldwide, and most of the new variants were discovered in the past 3 years, which calls for public alarm. The KPC variant protein enhances the affinity to ceftaz...
Source: Clinical Microbiology Reviews - November 8, 2023 Category: Microbiology Authors: Li Ding Siquan Shen Jing Chen Zhen Tian Qingyu Shi Renru Han Yan Guo Fupin Hu Source Type: research
Changes in fungal taxonomy: mycological rationale and clinical implications
Clin Microbiol Rev. 2023 Nov 6:e0009922. doi: 10.1128/cmr.00099-22. Online ahead of print.ABSTRACTSUMMARYNumerous fungal species of medical importance have been recently subjected to and will likely continue to undergo nomenclatural changes as a result of the application of molecular approaches to fungal classification together with abandonment of dual nomenclature. Here, we summarize those changes affecting key groups of fungi of medical importance, explaining the mycological (taxonomic) rationale that underpinned the changes and the clinical relevance/importance (where such exists) of the key nomenclatural revisions. Pot...
Source: Clinical Microbiology Reviews - November 6, 2023 Category: Microbiology Authors: Andrew M Borman Elizabeth M Johnson Source Type: research
Changes in fungal taxonomy: mycological rationale and clinical implications
Clin Microbiol Rev. 2023 Nov 6:e0009922. doi: 10.1128/cmr.00099-22. Online ahead of print.ABSTRACTSUMMARYNumerous fungal species of medical importance have been recently subjected to and will likely continue to undergo nomenclatural changes as a result of the application of molecular approaches to fungal classification together with abandonment of dual nomenclature. Here, we summarize those changes affecting key groups of fungi of medical importance, explaining the mycological (taxonomic) rationale that underpinned the changes and the clinical relevance/importance (where such exists) of the key nomenclatural revisions. Pot...
Source: Clinical Microbiology Reviews - November 6, 2023 Category: Microbiology Authors: Andrew M Borman Elizabeth M Johnson Source Type: research
MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets
Clin Microbiol Rev. 2023 Nov 1:e0001523. doi: 10.1128/cmr.00015-23. Online ahead of print.ABSTRACTSUMMARYMicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They have been implicated in the pathogenesis of cancer and neurological, cardiovascular, and autoimmune diseases. Several recent studies have suggested that miRNAs are key players in regulating the differentiation, maturation, and activation of immune cells, thereby influencing the host immune response to infection. The resultant upregulation or downregulation of miRNAs from infec...
Source: Clinical Microbiology Reviews - November 1, 2023 Category: Microbiology Authors: Muneyoshi Kimura Sagar Kothari Wajiha Gohir Jose F Camargo Shahid Husain Source Type: research
MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets
Clin Microbiol Rev. 2023 Nov 1:e0001523. doi: 10.1128/cmr.00015-23. Online ahead of print.ABSTRACTSUMMARYMicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They have been implicated in the pathogenesis of cancer and neurological, cardiovascular, and autoimmune diseases. Several recent studies have suggested that miRNAs are key players in regulating the differentiation, maturation, and activation of immune cells, thereby influencing the host immune response to infection. The resultant upregulation or downregulation of miRNAs from infec...
Source: Clinical Microbiology Reviews - November 1, 2023 Category: Microbiology Authors: Muneyoshi Kimura Sagar Kothari Wajiha Gohir Jose F Camargo Shahid Husain Source Type: research
