Biofilm antimicrobial susceptibility testing: where are we and where could we be going?
Clin Microbiol Rev. 2023 Oct 9:e0002423. doi: 10.1128/cmr.00024-23. Online ahead of print.ABSTRACTSUMMARYOur knowledge about the fundamental aspects of biofilm biology, including the mechanisms behind the reduced antimicrobial susceptibility of biofilms, has increased drastically over the last decades. However, this knowledge has so far not been translated into major changes in clinical practice. While the biofilm concept is increasingly on the radar of clinical microbiologists, physicians, and healthcare professionals in general, the standardized tools to study biofilms in the clinical microbiology laboratory are still la...
Source: Clinical Microbiology Reviews - October 9, 2023 Category: Microbiology Authors: Tom Coenye Source Type: research
Biofilm antimicrobial susceptibility testing: where are we and where could we be going?
Clin Microbiol Rev. 2023 Oct 9:e0002423. doi: 10.1128/cmr.00024-23. Online ahead of print.ABSTRACTSUMMARYOur knowledge about the fundamental aspects of biofilm biology, including the mechanisms behind the reduced antimicrobial susceptibility of biofilms, has increased drastically over the last decades. However, this knowledge has so far not been translated into major changes in clinical practice. While the biofilm concept is increasingly on the radar of clinical microbiologists, physicians, and healthcare professionals in general, the standardized tools to study biofilms in the clinical microbiology laboratory are still la...
Source: Clinical Microbiology Reviews - October 9, 2023 Category: Microbiology Authors: Tom Coenye Source Type: research
Biofilm antimicrobial susceptibility testing: where are we and where could we be going?
Clin Microbiol Rev. 2023 Oct 9:e0002423. doi: 10.1128/cmr.00024-23. Online ahead of print.ABSTRACTSUMMARYOur knowledge about the fundamental aspects of biofilm biology, including the mechanisms behind the reduced antimicrobial susceptibility of biofilms, has increased drastically over the last decades. However, this knowledge has so far not been translated into major changes in clinical practice. While the biofilm concept is increasingly on the radar of clinical microbiologists, physicians, and healthcare professionals in general, the standardized tools to study biofilms in the clinical microbiology laboratory are still la...
Source: Clinical Microbiology Reviews - October 9, 2023 Category: Microbiology Authors: Tom Coenye Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high de...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
Clin Microbiol Rev. 2023 Jul 13:e0001923. doi: 10.1128/cmr.00019-23. Online ahead of print.ABSTRACTFungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high deg...
Source: Clinical Microbiology Reviews - July 13, 2023 Category: Microbiology Authors: George R Thompson Jeffrey D Jenks John W Baddley James S Lewis Matthias Egger Ilan S Schwartz Johannes Boyer Thomas F Patterson Sharon C-A Chen Peter G Pappas Martin Hoenigl Source Type: research
