Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Chagas disease in immunocompromised patients
Clin Microbiol Rev. 2024 Mar 28:e0009923. doi: 10.1128/cmr.00099-23. Online ahead of print.ABSTRACTSUMMARYAs Chagas disease remains prevalent in the Americas, it is important that healthcare professionals and researchers are aware of the screening, diagnosis, monitoring, and treatment recommendations for the populations of patients they care for and study. Management of Trypanosoma cruzi infection in immunocompromised hosts is challenging, particularly because, regardless of antitrypanosomal treatment status, immunocompromised patients with Chagas disease are at risk for T. cruzi reactivation, which can be lethal. Evidence...
Source: Clinical Microbiology Reviews - March 28, 2024 Category: Microbiology Authors: Eva H Clark Louisa A Messenger Jeffrey D Whitman Caryn Bern Source Type: research
Chagas disease in immunocompromised patients
Clin Microbiol Rev. 2024 Mar 28:e0009923. doi: 10.1128/cmr.00099-23. Online ahead of print.ABSTRACTSUMMARYAs Chagas disease remains prevalent in the Americas, it is important that healthcare professionals and researchers are aware of the screening, diagnosis, monitoring, and treatment recommendations for the populations of patients they care for and study. Management of Trypanosoma cruzi infection in immunocompromised hosts is challenging, particularly because, regardless of antitrypanosomal treatment status, immunocompromised patients with Chagas disease are at risk for T. cruzi reactivation, which can be lethal. Evidence...
Source: Clinical Microbiology Reviews - March 28, 2024 Category: Microbiology Authors: Eva H Clark Louisa A Messenger Jeffrey D Whitman Caryn Bern Source Type: research
