Evolving mechanisms and presentations of cardiovascular disease in people with HIV: implications for management
Clin Microbiol Rev. 2024 Feb 1:e0009822. doi: 10.1128/cmr.00098-22. Online ahead of print.ABSTRACTSUMMARYPeople with HIV (PWH) are at elevated risk for cardiovascular diseases (CVDs), including myocardial infarction, heart failure, and sudden cardiac death, among other CVD manifestations. Chronic immune dysregulation resulting in persistent inflammation is common among PWH, particularly those with sustained viremia and impaired CD4+ T cell recovery. This inflammatory milieu is a major contributor to CVDs among PWH, in concert with common comorbidities (such as dyslipidemia and smoking) and, to a lesser extent, off-target e...
Source: Clinical Microbiology Reviews - February 1, 2024 Category: Microbiology Authors: Ilana Nazari Matthew J Feinstein Source Type: research
Advancements and challenges in antifungal therapeutic development
Clin Microbiol Rev. 2024 Jan 31:e0014223. doi: 10.1128/cmr.00142-23. Online ahead of print.ABSTRACTSUMMARYOver recent decades, the global burden of fungal disease has expanded dramatically. It is estimated that fungal disease kills approximately 1.5 million individuals annually; however, the true worldwide burden of fungal infection is thought to be higher due to existing gaps in diagnostics and clinical understanding of mycotic disease. The development of resistance to antifungals across diverse pathogenic fungal genera is an increasingly common and devastating phenomenon due to the dearth of available antifungal classes....
Source: Clinical Microbiology Reviews - January 31, 2024 Category: Microbiology Authors: Emily Puumala Sara Fallah Nicole Robbins Leah E Cowen Source Type: research
Overcoming barriers and stigma: new frontiers in solid organ transplantation for people with HIV
This article first reviews the current state of organ transplantation from donors without HIV to recipients with HIV (HIV D-/R+) by organ and discusses key lessons learned from these transplant trials, including those about drug-drug interactions, rejection, and opportunistic infections. It then explores transplantation from donors with HIV to recipients with HIV (HIV D+/R+), a new frontier. Finally, it investigates challenges of implementation, including public awareness and regulatory requirements, and explores future directions for SOT in people living with HIV.PMID:38240603 | DOI:10.1128/cmr.00111-22 (Source: Clinical ...
Source: Clinical Microbiology Reviews - January 19, 2024 Category: Microbiology Authors: K Storm C M Durand Source Type: research
< em > Pneumocystis jirovecii < /em > pneumonia in people living with HIV: a review
Clin Microbiol Rev. 2024 Jan 18:e0010122. doi: 10.1128/cmr.00101-22. Online ahead of print.ABSTRACTSUMMARYPneumocystis jirovecii is a ubiquitous opportunistic fungus that can cause life-threatening pneumonia. People with HIV (PWH) who have low CD4 counts are one of the populations at the greatest risk of Pneumocystis jirovecii pneumonia (PCP). While guidelines have approached the diagnosis, prophylaxis, and management of PCP, the numerous studies of PCP in PWH are dominated by the 1980s and 1990s. As such, most studies have included younger male populations, despite PCP affecting both sexes and a broad age range. Many stud...
Source: Clinical Microbiology Reviews - January 18, 2024 Category: Microbiology Authors: Emily G McDonald Avideh Afshar Bander Assiri Tom Boyles Jimmy M Hsu Ninh Khuong Connor Prosty Miranda So Zahra N Sohani Guillaume Butler-Laporte Todd C Lee Source Type: research
< em > Neisseria gonorrhoeae < /em > vaccines: a contemporary overview
Clin Microbiol Rev. 2024 Jan 16:e0009423. doi: 10.1128/cmr.00094-23. Online ahead of print.ABSTRACTSUMMARYNeisseria gonorrhoeae infection is an important public health issue, with an annual global incidence of 87 million. N. gonorrhoeae infection causes significant morbidity and can have serious long-term impacts on reproductive and neonatal health and may rarely cause life-threatening disease. Global rates of N. gonorrhoeae infection have increased over the past 20 years. Importantly, rates of antimicrobial resistance to key antimicrobials also continue to increase, with the United States Centers for Disease Control and P...
Source: Clinical Microbiology Reviews - January 16, 2024 Category: Microbiology Authors: Eloise Williams Kate L Seib Christopher K Fairley Georgina L Pollock Jane S Hocking James S McCarthy Deborah A Williamson Source Type: research
Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Clin Microbiol Rev. 2024 Jan 3:e0000923. doi: 10.1128/cmr.00009-23. Online ahead of print.ABSTRACTSUMMARYClonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma...
Source: Clinical Microbiology Reviews - January 3, 2024 Category: Microbiology Authors: Men-Bao Qian Jennifer Keiser J ürg Utzinger Xiao-Nong Zhou Source Type: research
Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Clin Microbiol Rev. 2024 Jan 3:e0000923. doi: 10.1128/cmr.00009-23. Online ahead of print.ABSTRACTSUMMARYClonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma...
Source: Clinical Microbiology Reviews - January 3, 2024 Category: Microbiology Authors: Men-Bao Qian Jennifer Keiser J ürg Utzinger Xiao-Nong Zhou Source Type: research
Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Clin Microbiol Rev. 2024 Jan 3:e0000923. doi: 10.1128/cmr.00009-23. Online ahead of print.ABSTRACTSUMMARYClonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma...
Source: Clinical Microbiology Reviews - January 3, 2024 Category: Microbiology Authors: Men-Bao Qian Jennifer Keiser J ürg Utzinger Xiao-Nong Zhou Source Type: research
Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Clin Microbiol Rev. 2024 Jan 3:e0000923. doi: 10.1128/cmr.00009-23. Online ahead of print.ABSTRACTSUMMARYClonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma...
Source: Clinical Microbiology Reviews - January 3, 2024 Category: Microbiology Authors: Men-Bao Qian Jennifer Keiser J ürg Utzinger Xiao-Nong Zhou Source Type: research
Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Clin Microbiol Rev. 2024 Jan 3:e0000923. doi: 10.1128/cmr.00009-23. Online ahead of print.ABSTRACTSUMMARYClonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma...
Source: Clinical Microbiology Reviews - January 3, 2024 Category: Microbiology Authors: Men-Bao Qian Jennifer Keiser J ürg Utzinger Xiao-Nong Zhou Source Type: research
Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Clin Microbiol Rev. 2024 Jan 3:e0000923. doi: 10.1128/cmr.00009-23. Online ahead of print.ABSTRACTSUMMARYClonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma...
Source: Clinical Microbiology Reviews - January 3, 2024 Category: Microbiology Authors: Men-Bao Qian Jennifer Keiser J ürg Utzinger Xiao-Nong Zhou Source Type: research
2023 Acknowledgment of CMR Reviewers
Clin Microbiol Rev. 2023 Dec 20;36(4):e0013823. doi: 10.1128/cmr.00138-23. Epub 2023 Dec 20.NO ABSTRACTPMID:38117085 | PMC:PMC10732054 | DOI:10.1128/cmr.00138-23 (Source: Clinical Microbiology Reviews)
Source: Clinical Microbiology Reviews - December 20, 2023 Category: Microbiology Authors: Graeme Forrest Source Type: research
2023 Acknowledgment of CMR Reviewers
Clin Microbiol Rev. 2023 Dec 20;36(4):e0013823. doi: 10.1128/cmr.00138-23. Epub 2023 Dec 20.NO ABSTRACTPMID:38117085 | DOI:10.1128/cmr.00138-23 (Source: Clinical Microbiology Reviews)
Source: Clinical Microbiology Reviews - December 20, 2023 Category: Microbiology Authors: Graeme Forrest Source Type: research
Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond
Clin Microbiol Rev. 2023 Dec 14:e0010322. doi: 10.1128/cmr.00103-22. Online ahead of print.ABSTRACTSUMMARYWastewater-based surveillance (WBS) has undergone dramatic advancement in the context of the coronavirus disease 2019 (COVID-19) pandemic. The power and potential of this platform technology were rapidly realized when it became evident that not only did WBS-measured SARS-CoV-2 RNA correlate strongly with COVID-19 clinical disease within monitored populations but also, in fact, it functioned as a leading indicator. Teams from across the globe rapidly innovated novel approaches by which wastewater could be collected from...
Source: Clinical Microbiology Reviews - December 14, 2023 Category: Microbiology Authors: Michael D Parkins Bonita E Lee Nicole Acosta Maria Bautista Casey R J Hubert Steve E Hrudey Kevin Frankowski Xiao-Li Pang Source Type: research
Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond
Clin Microbiol Rev. 2023 Dec 14:e0010322. doi: 10.1128/cmr.00103-22. Online ahead of print.ABSTRACTSUMMARYWastewater-based surveillance (WBS) has undergone dramatic advancement in the context of the coronavirus disease 2019 (COVID-19) pandemic. The power and potential of this platform technology were rapidly realized when it became evident that not only did WBS-measured SARS-CoV-2 RNA correlate strongly with COVID-19 clinical disease within monitored populations but also, in fact, it functioned as a leading indicator. Teams from across the globe rapidly innovated novel approaches by which wastewater could be collected from...
Source: Clinical Microbiology Reviews - December 14, 2023 Category: Microbiology Authors: Michael D Parkins Bonita E Lee Nicole Acosta Maria Bautista Casey R J Hubert Steve E Hrudey Kevin Frankowski Xiao-Li Pang Source Type: research
