Invasive fusariosis

Clin Microbiol Rev. 2023 Nov 8:e0015922. doi: 10.1128/cmr.00159-22. Online ahead of print.ABSTRACTSUMMARYInvasive fusariosis is a serious invasive fungal disease, affecting immunocompetent and, more frequently, immunocompromised patients. Localized disease is the typical clinical form in immunocompetent patients. Immunocompromised hosts at elevated risk of developing invasive fusariosis are patients with acute leukemia receiving chemotherapeutic regimens for remission induction, and those undergoing allogeneic hematopoietic cell transplant. In this setting, the infection is usually disseminated with positive blood cultures, multiple painful metastatic skin lesions, and lung involvement. Currently available antifungal agents have poor in vitro activity against Fusarium species, but a clear-cut correlation between in vitro activity and clinical effectiveness does not exist. The outcome of invasive fusariosis is largely dependent on the resolution of immunosuppression, especially neutrophil recovery in neutropenic patients.PMID:37937988 | DOI:10.1128/cmr.00159-22
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Source Type: research