Recent advances in the involvement of epigenetics in the pathogenesis of systemic lupus erythematosus
Clin Immunol. 2023 Dec 1:109857. doi: 10.1016/j.clim.2023.109857. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a typical systemic autoimmune disease that manifests as skin rash, arthritis, lymphadenopathy, and multiple organ lesions. Epigenetics, including DNA methylation, histone modification, and non-coding RNA regulation, mainly affect the function and characteristics of cells through the regulation of gene transcription or translation. Increasing evidence indicates that there are a variety of complex epigenetic effects in patients with SLE, which interfere with the differentiation and function of...
Source: Clinical Immunology - December 3, 2023 Category: Allergy & Immunology Authors: Hong-Yan Zhou Qi Luo Hua Sui Xiang-Ning Du Yang-Jianing Zhao Lu Liu Qing Guan Yue Zhou Qing-Si Wen Yan Shi Yu Sun Hong-Li Lin Da-Peng Wang Source Type: research
Recent advances in the involvement of epigenetics in the pathogenesis of systemic lupus erythematosus
Clin Immunol. 2023 Dec 1:109857. doi: 10.1016/j.clim.2023.109857. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a typical systemic autoimmune disease that manifests as skin rash, arthritis, lymphadenopathy, and multiple organ lesions. Epigenetics, including DNA methylation, histone modification, and non-coding RNA regulation, mainly affect the function and characteristics of cells through the regulation of gene transcription or translation. Increasing evidence indicates that there are a variety of complex epigenetic effects in patients with SLE, which interfere with the differentiation and function of...
Source: Clinical Immunology - December 3, 2023 Category: Allergy & Immunology Authors: Hong-Yan Zhou Qi Luo Hua Sui Xiang-Ning Du Yang-Jianing Zhao Lu Liu Qing Guan Yue Zhou Qing-Si Wen Yan Shi Yu Sun Hong-Li Lin Da-Peng Wang Source Type: research
Recent advances in the involvement of epigenetics in the pathogenesis of systemic lupus erythematosus
Clin Immunol. 2023 Dec 1:109857. doi: 10.1016/j.clim.2023.109857. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a typical systemic autoimmune disease that manifests as skin rash, arthritis, lymphadenopathy, and multiple organ lesions. Epigenetics, including DNA methylation, histone modification, and non-coding RNA regulation, mainly affect the function and characteristics of cells through the regulation of gene transcription or translation. Increasing evidence indicates that there are a variety of complex epigenetic effects in patients with SLE, which interfere with the differentiation and function of...
Source: Clinical Immunology - December 3, 2023 Category: Allergy & Immunology Authors: Hong-Yan Zhou Qi Luo Hua Sui Xiang-Ning Du Yang-Jianing Zhao Lu Liu Qing Guan Yue Zhou Qing-Si Wen Yan Shi Yu Sun Hong-Li Lin Da-Peng Wang Source Type: research
Natural supplements in antiphospholipid syndrome: A case for further study
The objective of this review is to summarize the mechanistic, epidemiologic and clinical evidence behind the use of natural supplements in APS, with a specific focus on vitamin D, omega-3 fatty acids, coenzyme Q10, gingerol, and isoquercetin. This review should serve as a compelling argument for the future study of natural supplements in APS.PMID:38036277 | DOI:10.1016/j.clim.2023.109848 (Source: Clinical Immunology)
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Nina Kello Young Min Cho Source Type: research
Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment
Clin Immunol. 2023 Nov 28;257:109855. doi: 10.1016/j.clim.2023.109855. Online ahead of print.ABSTRACTWe characterized a family diagnosed with immunodeficiency disease presenting with low immunoglobulin levels and skin dyskeratosis. Exome sequencing revealed compound heterozygous missense variants in SLC5A6, the gene encoding a cellular sodium-dependent multivitamin transporter (SMVT) responsible for transporting vitamins, including biotin (vitamin B7). We showed that the biotin deficiency was caused by the SLC5A6 variants resulting in defective B cell differentiation and antibody deficiency. Altered cellular metabolic prof...
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Chu-Han Hsieh Ju Lee Hsiang-Hsuan Sung Ya-Fang Huang Yu-Sian Ding Chia-Yi Li Chia-Liang Yen Chao-Kai Hsu Chun-Keung Yu Hsin-Ying Hsieh Michael Warren Hughes Peng-Chieh Chen Chi-Chang Shieh Source Type: research
The potential roles and mechanisms of Chitinase-3-like-1 in the pathogenesis of type 2-biased airway diseases
Clin Immunol. 2023 Nov 28;257:109856. doi: 10.1016/j.clim.2023.109856. Online ahead of print.ABSTRACTThe immune modulation in the epithelium is a protective feature of the epithelial function in the mucosal airways. Dysfunction of the epithelium can lead to chronic allergic airway inflammatory diseases, such as chronic rhinosinusitis with nasal polyps (CRSwNP), allergic rhinitis (AR), and allergic asthma. Chitinase-3-like-1 (CHI3L1) is a key modulator in the epithelium against irritants, pathogens, and allergens and is involved in cancers, autoimmune diseases, neurological disorders, and other chronic diseases. Induction o...
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Yian Zhou Zheng Liu Yang Liu Source Type: research
Natural supplements in antiphospholipid syndrome: A case for further study
The objective of this review is to summarize the mechanistic, epidemiologic and clinical evidence behind the use of natural supplements in APS, with a specific focus on vitamin D, omega-3 fatty acids, coenzyme Q10, gingerol, and isoquercetin. This review should serve as a compelling argument for the future study of natural supplements in APS.PMID:38036277 | DOI:10.1016/j.clim.2023.109848 (Source: Clinical Immunology)
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Nina Kello Young Min Cho Source Type: research
Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment
Clin Immunol. 2023 Nov 28:109855. doi: 10.1016/j.clim.2023.109855. Online ahead of print.ABSTRACTWe characterized a family diagnosed with immunodeficiency disease presenting with low immunoglobulin levels and skin dyskeratosis. Exome sequencing revealed compound heterozygous missense variants in SLC5A6, the gene encoding a cellular sodium-dependent multivitamin transporter (SMVT) responsible for transporting vitamins, including biotin (vitamin B7). We showed that the biotin deficiency was caused by the SLC5A6 variants resulting in defective B cell differentiation and antibody deficiency. Altered cellular metabolic profiles...
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Chu-Han Hsieh Ju Lee Hsiang-Hsuan Sung Ya-Fang Huang Yu-Sian Ding Chia-Yi Li Chia-Liang Yen Chao-Kai Hsu Chun-Keung Yu Hsin-Ying Hsieh Michael Warren Hughes Peng-Chieh Chen Chi-Chang Shieh Source Type: research
The potential roles and mechanisms of Chitinase-3-like-1 in the pathogenesis of type 2-biased airway diseases
Clin Immunol. 2023 Nov 28:109856. doi: 10.1016/j.clim.2023.109856. Online ahead of print.ABSTRACTThe immune modulation in the epithelium is a protective feature of the epithelial function in the mucosal airways. Dysfunction of the epithelium can lead to chronic allergic airway inflammatory diseases, such as chronic rhinosinusitis with nasal polyps (CRSwNP), allergic rhinitis (AR), and allergic asthma. Chitinase-3-like-1 (CHI3L1) is a key modulator in the epithelium against irritants, pathogens, and allergens and is involved in cancers, autoimmune diseases, neurological disorders, and other chronic diseases. Induction of ep...
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Yian Zhou Zheng Liu Yang Liu Source Type: research
Natural supplements in antiphospholipid syndrome: A case for further study
The objective of this review is to summarize the mechanistic, epidemiologic and clinical evidence behind the use of natural supplements in APS, with a specific focus on vitamin D, omega-3 fatty acids, coenzyme Q10, gingerol, and isoquercetin. This review should serve as a compelling argument for the future study of natural supplements in APS.PMID:38036277 | DOI:10.1016/j.clim.2023.109848 (Source: Clinical Immunology)
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Nina Kello Young Min Cho Source Type: research
Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment
Clin Immunol. 2023 Nov 28:109855. doi: 10.1016/j.clim.2023.109855. Online ahead of print.ABSTRACTWe characterized a family diagnosed with immunodeficiency disease presenting with low immunoglobulin levels and skin dyskeratosis. Exome sequencing revealed compound heterozygous missense variants in SLC5A6, the gene encoding a cellular sodium-dependent multivitamin transporter (SMVT) responsible for transporting vitamins, including biotin (vitamin B7). We showed that the biotin deficiency was caused by the SLC5A6 variants resulting in defective B cell differentiation and antibody deficiency. Altered cellular metabolic profiles...
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Chu-Han Hsieh Ju Lee Hsiang-Hsuan Sung Ya-Fang Huang Yu-Sian Ding Chia-Yi Li Chia-Liang Yen Chao-Kai Hsu Chun-Keung Yu Hsin-Ying Hsieh Michael Warren Hughes Peng-Chieh Chen Chi-Chang Shieh Source Type: research
The potential roles and mechanisms of Chitinase-3-like-1 in the pathogenesis of type 2-biased airway diseases
Clin Immunol. 2023 Nov 28:109856. doi: 10.1016/j.clim.2023.109856. Online ahead of print.ABSTRACTThe immune modulation in the epithelium is a protective feature of the epithelial function in the mucosal airways. Dysfunction of the epithelium can lead to chronic allergic airway inflammatory diseases, such as chronic rhinosinusitis with nasal polyps (CRSwNP), allergic rhinitis (AR), and allergic asthma. Chitinase-3-like-1 (CHI3L1) is a key modulator in the epithelium against irritants, pathogens, and allergens and is involved in cancers, autoimmune diseases, neurological disorders, and other chronic diseases. Induction of ep...
Source: Clinical Immunology - November 30, 2023 Category: Allergy & Immunology Authors: Yian Zhou Zheng Liu Yang Liu Source Type: research
Chlorophyll a and novel synthetic derivatives alleviate atopic dermatitis by suppressing Th2 cell differentiation via IL-4 receptor modulation
In conclusion, 4aa may be applied for novel therapeutic developments for patients with AD.PMID:38029848 | DOI:10.1016/j.clim.2023.109852 (Source: Clinical Immunology)
Source: Clinical Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Koon Mook Kang Jung-Hyun Han Kyeong Seok Kim Eun Kyung Kim Youna Shin Jae Hyeon Park Hyeon Kim Na Yoon Kim Yoon Gyoon Kim Hyunjun Kim Hyunjin Park Young-Mi Kim Seung-Jung Kee Seong-Jin Kim Hyung Sik Kim Yong-Chul Kim Source Type: research
Chlorophyll a and novel synthetic derivatives alleviate atopic dermatitis by suppressing Th2 cell differentiation via IL-4 receptor modulation
In conclusion, 4aa may be applied for novel therapeutic developments for patients with AD.PMID:38029848 | DOI:10.1016/j.clim.2023.109852 (Source: Clinical Immunology)
Source: Clinical Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Koon Mook Kang Jung-Hyun Han Kyeong Seok Kim Eun Kyung Kim Youna Shin Jae Hyeon Park Hyeon Kim Na Yoon Kim Yoon Gyoon Kim Hyunjun Kim Hyunjin Park Young-Mi Kim Seung-Jung Kee Seong-Jin Kim Hyung Sik Kim Yong-Chul Kim Source Type: research
Changes in mucosal IgG4 < sup > + < /sup > - and IL-10 < sup > + < /sup > -cell frequencies in adults with eosinophilic esophagitis on a two-food elimination diet
Clin Immunol. 2023 Nov 25:109853. doi: 10.1016/j.clim.2023.109853. Online ahead of print.ABSTRACTEosinophilic esophagitis (EoE) is increasingly diagnosed in patients with dysphagia. Type-2 immunity can induce EoE histopathology via non-IgE-dependent mechanisms, possibly involving IgG4 and IL-10. To elucidate the contribution of this response to EoE pathogenesis, we examined its association with clinical and histologic endpoints in adult EoE patients given a two-food elimination diet. IgG4- and IL-10-expressing cells were counted in esophageal biopsies and serum food-specific IgG4 measured at baseline and follow-up. Variabl...
Source: Clinical Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Ramapraba Appanna Domenico Gargano Alessandro Caputo Fabio De Bartolomeis Luca Ricciardi Antonella Santonicola Berenice Stefanelli Laura Caiazza Marialuisa Guarciariello Antonio D'Antonio Raffaella D'Auria Valeria Conti Vincenzo Casolaro Paola Iovino Source Type: research
