Immmunometabolism of systemic lupus erythematosus
Clin Immunol. 2024 Feb 19:109939. doi: 10.1016/j.clim.2024.109939. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a potentially fatal chronic autoimmune disease which is underlain by complex dysfunction of the innate and adaptive immune systems. Although a series of well-defined genetic and environmental factors have been implicated in disease etiology, neither the development nor the persistence of SLE is well understood. Given that several disease susceptibility genes and environmental factors interact and influence inflammatory lineage specification through metabolism, the field of immunometabolism ...
Source: Clinical Immunology - February 21, 2024 Category: Allergy & Immunology Authors: Marlene Marte Furment Andras Perl Source Type: research
Immmunometabolism of systemic lupus erythematosus
Clin Immunol. 2024 Feb 19:109939. doi: 10.1016/j.clim.2024.109939. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a potentially fatal chronic autoimmune disease which is underlain by complex dysfunction of the innate and adaptive immune systems. Although a series of well-defined genetic and environmental factors have been implicated in disease etiology, neither the development nor the persistence of SLE is well understood. Given that several disease susceptibility genes and environmental factors interact and influence inflammatory lineage specification through metabolism, the field of immunometabolism ...
Source: Clinical Immunology - February 21, 2024 Category: Allergy & Immunology Authors: Marlene Marte Furment Andras Perl Source Type: research
Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia
Clin Immunol. 2024 Feb 15;261:109942. doi: 10.1016/j.clim.2024.109942. Online ahead of print.ABSTRACTSevere combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, the...
Source: Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Roshini S Abraham Amrita Basu Jennifer R Heimall Elizabeth Dunn Alison Yip Malika Kapadia Neena Kapoor Lisa Forbes Satter Rebecca Buckley Richard O'Reilly Geoffrey D E Cuvelier Sharat Chandra Jeffrey Bednarski Sonali Chaudhury Theodore B Moore Hilary Hain Source Type: research
Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia
Clin Immunol. 2024 Feb 15;261:109942. doi: 10.1016/j.clim.2024.109942. Online ahead of print.ABSTRACTSevere combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, the...
Source: Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Roshini S Abraham Amrita Basu Jennifer R Heimall Elizabeth Dunn Alison Yip Malika Kapadia Neena Kapoor Lisa Forbes Satter Rebecca Buckley Richard O'Reilly Geoffrey D E Cuvelier Sharat Chandra Jeffrey Bednarski Sonali Chaudhury Theodore B Moore Hilary Hain Source Type: research
Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia
Clin Immunol. 2024 Feb 15;261:109942. doi: 10.1016/j.clim.2024.109942. Online ahead of print.ABSTRACTSevere combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, the...
Source: Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Roshini S Abraham Amrita Basu Jennifer R Heimall Elizabeth Dunn Alison Yip Malika Kapadia Neena Kapoor Lisa Forbes Satter Rebecca Buckley Richard O'Reilly Geoffrey D E Cuvelier Sharat Chandra Jeffrey Bednarski Sonali Chaudhury Theodore B Moore Hilary Hain Source Type: research
Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia
Clin Immunol. 2024 Feb 15:109942. doi: 10.1016/j.clim.2024.109942. Online ahead of print.ABSTRACTSevere combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there w...
Source: Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Roshini S Abraham Amrita Basu Jennifer R Heimall Elizabeth Dunn Alison Yip Malika Kapadia Neena Kapoor Lisa Forbes Satter Rebecca Buckley Richard O'Reilly Geoffrey D E Cuvelier Sharat Chandra Jeffrey Bednarski Sonali Chaudhury Theodore B Moore Hilary Hain Source Type: research
Bruton's tyrosine kinase ablation inhibits B cell responses and antibody production for the prevention of chronic rejection in cardiac transplantation
This study investigated the efficacy of blocking BTK signalling in the prevention of chronic rejection. BTK signalling was blocked using the BTK inhibitor ibrutinib and gene knockout. In vitro assays were conducted to examine the consequences and underlying mechanisms of BTK blockade in regards to B cell activation, differentiation, and antibody secretion. Additionally, we established a cardiac transplantation mouse model of chronic rejection to explore the preventive effects and mechanisms of BTK ablation on chronic rejection. Ablating BTK signalling in vitro resulted in the inhibition of B cell activation, differentiatio...
Source: Clinical Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Fei Han Xiaoyi Shi Tao Liao Wei Zhang Maolin Ma Qianghua Leng Weichen Jiang Ning Na Yun Miao Zhengyu Huang Source Type: research
Progranulin promotes regulatory T cells plasticity by mitochondrial metabolism through AMPK/PGC-1 α pathway in ARDS
Clin Immunol. 2024 Feb 14:109940. doi: 10.1016/j.clim.2024.109940. Online ahead of print.ABSTRACTAs the aging population increases, the focus on elderly patients with acute respiratory distress syndrome (ARDS) is also increasing. In this article, we found progranulin (PGRN) differential expression in ARDS patients and healthy controls, even in young and old ARDS patients. Its expression strongly correlates with several cytokines in both young and elderly ARDS patients. PGRN has comparable therapeutic effects in young and elderly mice with lipopolysaccharide-induced acute lung injury, manifesting as lung injury, apoptosis, ...
Source: Clinical Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Yanqing Chen Minkang Guo Ke Xie Ming Lei Yusen Chai Zhengtao Zhang Zhenhua Deng Qiaozhi Peng Ju Cao Shihui Lin Fang Xu Source Type: research
Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome
Clin Immunol. 2024 Feb 12:109926. doi: 10.1016/j.clim.2024.109926. Online ahead of print.ABSTRACTOur study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0.008), anti-phosphatidylserine/prot...
Source: Clinical Immunology - February 14, 2024 Category: Allergy & Immunology Authors: Elizabeth E Sloan Katarina Kmetova Somanathapura K NaveenKumar Lyndsay Kluge Emily Chong Claire K Hoy Srilakshmi Yalavarthi Cyrus Sarosh Jeanine Baisch Lynnette Walters Lorien Nassi Julie Fuller Jessica L Turnier Virginia Pascual Tracey B Wright Jacquelin Source Type: research
Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome
Clin Immunol. 2024 Feb 12:109926. doi: 10.1016/j.clim.2024.109926. Online ahead of print.ABSTRACTOur study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0.008), anti-phosphatidylserine/prot...
Source: Clinical Immunology - February 14, 2024 Category: Allergy & Immunology Authors: Elizabeth E Sloan Katarina Kmetova Somanathapura K NaveenKumar Lyndsay Kluge Emily Chong Claire K Hoy Srilakshmi Yalavarthi Cyrus Sarosh Jeanine Baisch Lynnette Walters Lorien Nassi Julie Fuller Jessica L Turnier Virginia Pascual Tracey B Wright Jacquelin Source Type: research
Determining reference ranges for lymphocyte proliferation responses to phytohemagglutinin and Bacillus Calmette-Gu érin in Iranian children
CONCLUSION: This study establishes PHA-SI and BCG-SI reference ranges to aid in diagnosing and treating congenital immunodeficiency diseases.PMID:38346463 | DOI:10.1016/j.clim.2024.109937 (Source: Clinical Immunology)
Source: Clinical Immunology - February 12, 2024 Category: Allergy & Immunology Authors: Maryam Nourizadeh Shokouh Azam Sarrafzadeh Raheleh Shokouhi Shoormasti Mohammad Reza Fazlollahi Shiva Saghafi Mohsen Badalzadeh Milad Mirmoghtadaei Zahra Pourpak Source Type: research
Z-nucleic acid sensor ZBP1 in sterile inflammation
Clin Immunol. 2024 Feb 10:109938. doi: 10.1016/j.clim.2024.109938. Online ahead of print.ABSTRACTZ-DNA binding protein 1 (ZBP1), a cytosolic nucleic acid sensor for Z-form nucleic acids (Z-NA), can detect both exogenous and endogenous nucleic acids. Upon sensing of self Z-NA or exposure to diverse noxious stimuli, ZBP1 regulates inflammation by activating nuclear factor kappa B and interferon regulating factor 3 signaling pathways. In addition, ZBP1 promotes the assembly of ZBP1 PANoptosome, which initiates caspase 3-mediated apoptosis, mixed lineage kinase domain like pseudokinase (MLKL)-mediated necroptosis, and gasdermi...
Source: Clinical Immunology - February 12, 2024 Category: Allergy & Immunology Authors: Qixiang Song Zehong Qi Kangkai Wang Nian Wang Source Type: research
Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery
Clin Immunol. 2024 Feb 9;261:109930. doi: 10.1016/j.clim.2024.109930. Online ahead of print.ABSTRACTWhile the efficacy of many current vaccines is well-established, various factors can diminish their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats, enhancing vaccine responses is critical. Our review synthesizes insights from immunology and epidemiology, focusing on the concept of trained immunity (TRIM) and the non-specific effects (NSEs) of vaccines that confer heterologous protection. We elucidate the mechanisms driving TRIM, emphasizing its regulation through metabolic and epigenetic r...
Source: Clinical Immunology - February 11, 2024 Category: Allergy & Immunology Authors: Ilayda Baydemir Elisabeth A Dulfer Mihai G Netea Jorge Dom ínguez-Andrés Source Type: research
Age-specific Metabolomic profiles in children with food allergy
CONCLUSIONS: FA children of different ages manifest unique metabolic changes which may reflect at least in part pathogenic mechanisms and environmental influences operative at different time points in the disease course.PMID:38336145 | DOI:10.1016/j.clim.2024.109928 (Source: Clinical Immunology)
Source: Clinical Immunology - February 9, 2024 Category: Allergy & Immunology Authors: E Crestani M Benamar W Phipatanakul R Rachid T A Chatila Source Type: research
Involvement of expanded cytotoxic and proinflammatory CD28 < sup > null < /sup > T cells in primary Sj ögren's syndrome
CONCLUSION: Increasing CD28null T cells with strong cytotoxicity and proinflammatory effects were observed in both peripheral blood and MSGs from pSS patients. The precise mechanism of action and migration still needs further investigation.PMID:38331302 | DOI:10.1016/j.clim.2024.109927 (Source: Clinical Immunology)
Source: Clinical Immunology - February 8, 2024 Category: Allergy & Immunology Authors: Chuiwen Deng Anqi Wang Wenli Li Lidan Zhao Jiaxin Zhou Wen Zhang Mengtao Li Yunyun Fei Source Type: research
