Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force
CONCLUSIONS: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.PMID:38604255 | DOI:10.1016/j.clim.2024.110214 (Source: Clinical Immunology)
Source: Clinical Immunology - April 11, 2024 Category: Allergy & Immunology Authors: E M D Smith A Aggarwal J Ainsworth E Al-Abadi T Avcin L Bortey J Burnham C Ciurtin C M Hedrich S Kamphuis L Lambert D M Levy L Lewandowski N Maxwell E Morand S Özen C E Pain A Ravelli C Saad Magalhaes C Pilkington D Schonenberg-Meinema C Scott K Tullus M Source Type: research
P75 < sup > NTR+ < /sup > CD64 < sup > + < /sup > neutrophils promote sepsis-induced acute lung injury
In this study, we found a significant elevation of CD64+ neutrophils, which highly expressed p75 neurotrophin receptor (p75NTR) in peripheral blood of mice and patients with sepsis-induced ALI. p75NTR+CD64+ neutrophils were also abundantly expressed in the lung of ALI mice induced by lipopolysaccharide. Conditional knock-out of the myeloid lineage's p75NTR gene improved the survival rates, attenuated lung tissue inflammation, reduced neutrophil infiltration and enhanced the phagocytic functions of CD64+ neutrophils. In vitro, p75NTR+CD64+ neutrophils exhibited an upregulation and compromised phagocytic activity in blood sa...
Source: Clinical Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Di Fu Shan Gao Jia-Nan Li Yan-Hui Cui Yan-Wei Luo Yan-Jun Zhong Qiao Li Cong Luo Ru-Ping Dai Ru-Yi Luo Zhao-Lan Hu Source Type: research
P75 < sup > NTR+ < /sup > CD64 < sup > + < /sup > neutrophils promote sepsis-induced acute lung injury
In this study, we found a significant elevation of CD64+ neutrophils, which highly expressed p75 neurotrophin receptor (p75NTR) in peripheral blood of mice and patients with sepsis-induced ALI. p75NTR+CD64+ neutrophils were also abundantly expressed in the lung of ALI mice induced by lipopolysaccharide. Conditional knock-out of the myeloid lineage's p75NTR gene improved the survival rates, attenuated lung tissue inflammation, reduced neutrophil infiltration and enhanced the phagocytic functions of CD64+ neutrophils. In vitro, p75NTR+CD64+ neutrophils exhibited an upregulation and compromised phagocytic activity in blood sa...
Source: Clinical Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Di Fu Shan Gao Jia-Nan Li Yan-Hui Cui Yan-Wei Luo Yan-Jun Zhong Qiao Li Cong Luo Ru-Ping Dai Ru-Yi Luo Zhao-Lan Hu Source Type: research
New and emerging therapies for systemic lupus erythematosus
Clin Immunol. 2024 Apr 4:110200. doi: 10.1016/j.clim.2024.110200. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targetin...
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Eleni Papachristodoulou Vasileios C Kyttaris Source Type: research
Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia
CONCLUSION: Our findings present a provocative possibility of resetting R-loops as a therapeutic intervention to correct both immune deficiency and malignancy in T-cell acute lymphoblastic leukemia patients and a novel role of WASp in the epigenetic regulation of T helper cell differentiation in T-ALL patients, anticipating WASp's requirement for the suppression of T-ALL progression.PMID:38582251 | DOI:10.1016/j.clim.2024.110204 (Source: Clinical Immunology)
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: R Pradeep Sudeshna Rakshit Geetha Shanmugam Melvin George Koustav Sarkar Source Type: research
New and emerging therapies for systemic lupus erythematosus
Clin Immunol. 2024 Apr 4:110200. doi: 10.1016/j.clim.2024.110200. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targetin...
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Eleni Papachristodoulou Vasileios C Kyttaris Source Type: research
Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia
CONCLUSION: Our findings present a provocative possibility of resetting R-loops as a therapeutic intervention to correct both immune deficiency and malignancy in T-cell acute lymphoblastic leukemia patients and a novel role of WASp in the epigenetic regulation of T helper cell differentiation in T-ALL patients, anticipating WASp's requirement for the suppression of T-ALL progression.PMID:38582251 | DOI:10.1016/j.clim.2024.110204 (Source: Clinical Immunology)
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: R Pradeep Sudeshna Rakshit Geetha Shanmugam Melvin George Koustav Sarkar Source Type: research
New and emerging therapies for systemic lupus erythematosus
Clin Immunol. 2024 Apr 4:110200. doi: 10.1016/j.clim.2024.110200. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving FDA approval in the last 3 years. Herein we provide an overview of targeted therapies for SLE including medications targetin...
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Eleni Papachristodoulou Vasileios C Kyttaris Source Type: research
Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia
CONCLUSION: Our findings present a provocative possibility of resetting R-loops as a therapeutic intervention to correct both immune deficiency and malignancy in T-cell acute lymphoblastic leukemia patients and a novel role of WASp in the epigenetic regulation of T helper cell differentiation in T-ALL patients, anticipating WASp's requirement for the suppression of T-ALL progression.PMID:38582251 | DOI:10.1016/j.clim.2024.110204 (Source: Clinical Immunology)
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: R Pradeep Sudeshna Rakshit Geetha Shanmugam Melvin George Koustav Sarkar Source Type: research
Identification of connective tissue disease autoantibodies and a novel autoantibody anti-annexin A11 in patients with "idiopathic" interstitial lung disease
CONCLUSION: Specific guidance on autoantibody testing and interpretation in patients with ILD could improve diagnostic accuracy. Further work is required to determine the clinical significance of anti-annexin A11.PMID:38575043 | DOI:10.1016/j.clim.2024.110201 (Source: Clinical Immunology)
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Sarah L Tansley Fionnuala McMorrow Caroline V Cotton Huzaifa Adamali Shaney L Barratt Zoe E Betteridge Janire Perurena-Prieto Michael A Gibbons Raman Kular Aravinthan Loganathan Janine A Lamb Hui Lu Robert P New Diane Pratt Pilar Rivera-Ortega Ross Sayers Source Type: research
Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity
In this study, we build up a metal-coding assisted multiplexed proteome assay platform for serum metalloproteomic and immunoproteomic profiling. By taking COVID-19 as a showcase, we unbiasedly uncovered the most evident modulation of iron-related proteins, i.e., Ft and Tf, in serum of severe COVID-19 patients, and the value of Ft/Tf could work as a robust biomarker for COVID-19 severity stratification, which overtakes the well-established clinical risk factors (cytokines). We further uncovered a tight association of transferrin with inflammation mediator IL-10 in COVID-19 patients, which was proved to be mainly governed by...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Ying Zhou Tianfan Cheng Kaiming Tang Hongyan Li Cuiting Luo Fu Yu Fan Xiao Lijian Jin Ivan Fan-Ngai Hung Liwei Lu Kwok-Yung Yuen Jasper Fuk-Woo Chan Shuofeng Yuan Hongzhe Sun Source Type: research
Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily
Clin Immunol. 2024 Apr 2:110202. doi: 10.1016/j.clim.2024.110202. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-driven disease characterized by tissue damage in the small intestine of genetically-susceptible individuals. We evaluated here a crucial immune regulatory pathway involving TYRO3, AXL, and MERTK (TAM) receptors and their ligands PROS1 and GAS6 in duodenal biopsies of controls and CD patients. We found increased GAS6 expression associated with downregulation of PROS1 and variable TAM receptors levels in duodenum tissue of CD patients. Interestingly, CD3+ lymphocytes, CD68+, CD11c+ myeloid and epit...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Federico Perez Mar ía Luz Iribarren Cinthia Mariel Olexen Carolina Naym é Ruera Andrea Emilse Errasti Luciana Guzman Laura Garbi Eugenio Antonio Carrera-Silva Fernando Gabriel Chirdo Source Type: research
Increased AXL < sup > high < /sup > myeloid cells as pathognomonic marker in Langerhans cell histiocytosis and Langerin expression dependence of mTOR inhibition
Clin Immunol. 2024 Apr 2:110203. doi: 10.1016/j.clim.2024.110203. Online ahead of print.ABSTRACTLangerhans cell histiocytosis (LCH) is characterized by an expansion and accumulation of pathological histiocytes expressing langerin (CD207) and CD1a in different organs under an inflammatory milieu. The origin of pathognomonic precursors of LCH is widely debated, but monocytes and pre dendritic cells (pre-DC) play significant role. Remarkable we found an expansion of AXLhigh cells in the CD11c+ subset of patients with active LCH, which also express the pathognomonic CD207 and CD1a. Moreover, we obtained a monocyte-derived LC-l...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Cinthia Mariel Olexen Denise Risnik Mar ía Catalina Lava Guido Luis Dalla Vecchia Diego Alfredo Rosso Andrea Emilse Errasti Eugenio Antonio Carrera Silva Source Type: research
Identification of connective tissue disease autoantibodies and a novel autoantibody anti-annexin A11 in patients with "idiopathic" interstitial lung disease
CONCLUSION: Specific guidance on autoantibody testing and interpretation in patients with ILD could improve diagnostic accuracy. Further work is required to determine the clinical significance of anti-annexin A11.PMID:38575043 | DOI:10.1016/j.clim.2024.110201 (Source: Clinical Immunology)
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Sarah L Tansley Fionnuala McMorrow Caroline V Cotton Huzaifa Adamali Shaney L Barratt Zoe E Betteridge Janire Perurena-Prieto Michael A Gibbons Raman Kular Aravinthan Loganathan Janine A Lamb Hui Lu Robert P New Diane Pratt Pilar Rivera-Ortega Ross Sayers Source Type: research
Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity
In this study, we build up a metal-coding assisted multiplexed proteome assay platform for serum metalloproteomic and immunoproteomic profiling. By taking COVID-19 as a showcase, we unbiasedly uncovered the most evident modulation of iron-related proteins, i.e., Ft and Tf, in serum of severe COVID-19 patients, and the value of Ft/Tf could work as a robust biomarker for COVID-19 severity stratification, which overtakes the well-established clinical risk factors (cytokines). We further uncovered a tight association of transferrin with inflammation mediator IL-10 in COVID-19 patients, which was proved to be mainly governed by...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Ying Zhou Tianfan Cheng Kaiming Tang Hongyan Li Cuiting Luo Fu Yu Fan Xiao Lijian Jin Ivan Fan-Ngai Hung Liwei Lu Kwok-Yung Yuen Jasper Fuk-Woo Chan Shuofeng Yuan Hongzhe Sun Source Type: research
