Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily
Clin Immunol. 2024 Apr 2:110202. doi: 10.1016/j.clim.2024.110202. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-driven disease characterized by tissue damage in the small intestine of genetically-susceptible individuals. We evaluated here a crucial immune regulatory pathway involving TYRO3, AXL, and MERTK (TAM) receptors and their ligands PROS1 and GAS6 in duodenal biopsies of controls and CD patients. We found increased GAS6 expression associated with downregulation of PROS1 and variable TAM receptors levels in duodenum tissue of CD patients. Interestingly, CD3+ lymphocytes, CD68+, CD11c+ myeloid and epit...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Federico Perez Mar ía Luz Iribarren Cinthia Mariel Olexen Carolina Naym é Ruera Andrea Emilse Errasti Luciana Guzman Laura Garbi Eugenio Antonio Carrera-Silva Fernando Gabriel Chirdo Source Type: research
Increased AXL < sup > high < /sup > myeloid cells as pathognomonic marker in Langerhans cell histiocytosis and Langerin expression dependence of mTOR inhibition
Clin Immunol. 2024 Apr 2:110203. doi: 10.1016/j.clim.2024.110203. Online ahead of print.ABSTRACTLangerhans cell histiocytosis (LCH) is characterized by an expansion and accumulation of pathological histiocytes expressing langerin (CD207) and CD1a in different organs under an inflammatory milieu. The origin of pathognomonic precursors of LCH is widely debated, but monocytes and pre dendritic cells (pre-DC) play significant role. Remarkable we found an expansion of AXLhigh cells in the CD11c+ subset of patients with active LCH, which also express the pathognomonic CD207 and CD1a. Moreover, we obtained a monocyte-derived LC-l...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Cinthia Mariel Olexen Denise Risnik Mar ía Catalina Lava Guido Luis Dalla Vecchia Diego Alfredo Rosso Andrea Emilse Errasti Eugenio Antonio Carrera Silva Source Type: research
Identification of connective tissue disease autoantibodies and a novel autoantibody anti-annexin A11 in patients with "idiopathic" interstitial lung disease
CONCLUSION: Specific guidance on autoantibody testing and interpretation in patients with ILD could improve diagnostic accuracy. Further work is required to determine the clinical significance of anti-annexin A11.PMID:38575043 | DOI:10.1016/j.clim.2024.110201 (Source: Clinical Immunology)
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Sarah L Tansley Fionnuala McMorrow Caroline V Cotton Huzaifa Adamali Shaney L Barratt Zoe E Betteridge Janire Perurena-Prieto Michael A Gibbons Raman Kular Aravinthan Loganathan Janine A Lamb Hui Lu Robert P New Diane Pratt Pilar Rivera-Ortega Ross Sayers Source Type: research
Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity
In this study, we build up a metal-coding assisted multiplexed proteome assay platform for serum metalloproteomic and immunoproteomic profiling. By taking COVID-19 as a showcase, we unbiasedly uncovered the most evident modulation of iron-related proteins, i.e., Ft and Tf, in serum of severe COVID-19 patients, and the value of Ft/Tf could work as a robust biomarker for COVID-19 severity stratification, which overtakes the well-established clinical risk factors (cytokines). We further uncovered a tight association of transferrin with inflammation mediator IL-10 in COVID-19 patients, which was proved to be mainly governed by...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Ying Zhou Tianfan Cheng Kaiming Tang Hongyan Li Cuiting Luo Fu Yu Fan Xiao Lijian Jin Ivan Fan-Ngai Hung Liwei Lu Kwok-Yung Yuen Jasper Fuk-Woo Chan Shuofeng Yuan Hongzhe Sun Source Type: research
Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily
Clin Immunol. 2024 Apr 2:110202. doi: 10.1016/j.clim.2024.110202. Online ahead of print.ABSTRACTCeliac disease (CD) is an immune-driven disease characterized by tissue damage in the small intestine of genetically-susceptible individuals. We evaluated here a crucial immune regulatory pathway involving TYRO3, AXL, and MERTK (TAM) receptors and their ligands PROS1 and GAS6 in duodenal biopsies of controls and CD patients. We found increased GAS6 expression associated with downregulation of PROS1 and variable TAM receptors levels in duodenum tissue of CD patients. Interestingly, CD3+ lymphocytes, CD68+, CD11c+ myeloid and epit...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Federico Perez Mar ía Luz Iribarren Cinthia Mariel Olexen Carolina Naym é Ruera Andrea Emilse Errasti Luciana Guzman Laura Garbi Eugenio Antonio Carrera-Silva Fernando Gabriel Chirdo Source Type: research
Increased AXL < sup > high < /sup > myeloid cells as pathognomonic marker in Langerhans cell histiocytosis and Langerin expression dependence of mTOR inhibition
Clin Immunol. 2024 Apr 2:110203. doi: 10.1016/j.clim.2024.110203. Online ahead of print.ABSTRACTLangerhans cell histiocytosis (LCH) is characterized by an expansion and accumulation of pathological histiocytes expressing langerin (CD207) and CD1a in different organs under an inflammatory milieu. The origin of pathognomonic precursors of LCH is widely debated, but monocytes and pre dendritic cells (pre-DC) play significant role. Remarkable we found an expansion of AXLhigh cells in the CD11c+ subset of patients with active LCH, which also express the pathognomonic CD207 and CD1a. Moreover, we obtained a monocyte-derived LC-l...
Source: Clinical Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Cinthia Mariel Olexen Denise Risnik Mar ía Catalina Lava Guido Luis Dalla Vecchia Diego Alfredo Rosso Andrea Emilse Errasti Eugenio Antonio Carrera Silva Source Type: research
Methylation levels of the IL10 gene in peripheral blood are related to the intractability of Graves' disease
Clin Immunol. 2024 Apr 1:110196. doi: 10.1016/j.clim.2024.110196. Online ahead of print.ABSTRACTThe prognosis of autoimmune thyroid diseases (AITDs), including Hashimoto's disease (HD) and Graves' disease (GD), is difficult to predict. DNA methylation regulates gene expression of immune mediating factors. Interleukin (IL)-10 is a Th2 cytokine that downregulates inflammatory cytokines produced by Th1 cells. To clarify the role of methylation of the IL10 gene in the prognosis of AITD, we evaluated the methylation levels of two CpG sites in the IL10 promoter using pyrosequencing. The methylation levels of the -185 CpG site of...
Source: Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Riku Kinoshita Naoya Inoue Yoshinori Iwatani Yusuke Noguchi Yoh Hidaka Mikio Watanabe Source Type: research
Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data
Clin Immunol. 2024 Mar 31:110199. doi: 10.1016/j.clim.2024.110199. Online ahead of print.ABSTRACTCell-cell communication is crucial for regulating signaling and cellular function. However, the precise cellular and molecular changes remain poorly understood in skin aging. Based on single-cell and bulk RNA data, we explored to assess the role of cell-cell ligand-receptor interaction in skin aging. We found that the macrophage migration inhibitory factor (MIF)/CD74 was significantly upregulated and frequent interactions were observed on fibroblasts in aged skin. Enrichment analysis and in vitro experiment revealed a close ass...
Source: Clinical Immunology - April 2, 2024 Category: Allergy & Immunology Authors: Songjiang Wu Yujie Ouyang Yibo Hu Ling Jiang Chuhan Fu Li Lei Yushan Zhang Haoran Guo Jinhua Huang Jing Chen Qinghai Zeng Source Type: research
Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data
Clin Immunol. 2024 Mar 31:110199. doi: 10.1016/j.clim.2024.110199. Online ahead of print.ABSTRACTCell-cell communication is crucial for regulating signaling and cellular function. However, the precise cellular and molecular changes remain poorly understood in skin aging. Based on single-cell and bulk RNA data, we explored to assess the role of cell-cell ligand-receptor interaction in skin aging. We found that the macrophage migration inhibitory factor (MIF)/CD74 was significantly upregulated and frequent interactions were observed on fibroblasts in aged skin. Enrichment analysis and in vitro experiment revealed a close ass...
Source: Clinical Immunology - April 2, 2024 Category: Allergy & Immunology Authors: Songjiang Wu Yujie Ouyang Yibo Hu Ling Jiang Chuhan Fu Li Lei Yushan Zhang Haoran Guo Jinhua Huang Jing Chen Qinghai Zeng Source Type: research
Retraction notice to "Glycogen synthase kinase-3 β inhibition attenuates the degree of arthritis caused by type II collagen in the mouse" [Clin. Immunol. 120/1 (2006) 57-67]
Clin Immunol. 2024 Mar 29:110198. doi: 10.1016/j.clim.2024.110198. Online ahead of print.NO ABSTRACTPMID:38555221 | DOI:10.1016/j.clim.2024.110198 (Source: Clinical Immunology)
Source: Clinical Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Salvatore Cuzzocrea Emanuela Mazzon Rosanna Di Paola Carmelo Mui à Concetta Crisafulli Laura Dugo Marika Collin Domenico Britti Achille P Caputi Christoph Thiemermann Source Type: research
Retraction notice to "Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody" [Clin. Immunol. 113/1 (2004) 64-73]
Clin Immunol. 2024 Mar 29:110197. doi: 10.1016/j.clim.2024.110197. Online ahead of print.NO ABSTRACTPMID:38555222 | DOI:10.1016/j.clim.2024.110197 (Source: Clinical Immunology)
Source: Clinical Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Rosanna Di Paola Roberto Di Marco Emanuela Mazzon Tiziana Genovese Klaus Bendtzen Battesimo Macri Ferdinando Nicoletti Salvatore Cuzzocrea Source Type: research
Retraction notice to "Glycogen synthase kinase-3 β inhibition attenuates the degree of arthritis caused by type II collagen in the mouse" [Clin. Immunol. 120/1 (2006) 57-67]
Clin Immunol. 2024 Mar 29:110198. doi: 10.1016/j.clim.2024.110198. Online ahead of print.NO ABSTRACTPMID:38555221 | DOI:10.1016/j.clim.2024.110198 (Source: Clinical Immunology)
Source: Clinical Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Salvatore Cuzzocrea Emanuela Mazzon Rosanna Di Paola Carmelo Mui à Concetta Crisafulli Laura Dugo Marika Collin Domenico Britti Achille P Caputi Christoph Thiemermann Source Type: research
Retraction notice to "Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody" [Clin. Immunol. 113/1 (2004) 64-73]
Clin Immunol. 2024 Mar 29:110197. doi: 10.1016/j.clim.2024.110197. Online ahead of print.NO ABSTRACTPMID:38555222 | DOI:10.1016/j.clim.2024.110197 (Source: Clinical Immunology)
Source: Clinical Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Rosanna Di Paola Roberto Di Marco Emanuela Mazzon Tiziana Genovese Klaus Bendtzen Battesimo Macri Ferdinando Nicoletti Salvatore Cuzzocrea Source Type: research
Retraction notice to "Glycogen synthase kinase-3 β inhibition attenuates the degree of arthritis caused by type II collagen in the mouse" [Clin. Immunol. 120/1 (2006) 57-67]
Clin Immunol. 2024 Mar 29:110198. doi: 10.1016/j.clim.2024.110198. Online ahead of print.NO ABSTRACTPMID:38555221 | DOI:10.1016/j.clim.2024.110198 (Source: Clinical Immunology)
Source: Clinical Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Salvatore Cuzzocrea Emanuela Mazzon Rosanna Di Paola Carmelo Mui à Concetta Crisafulli Laura Dugo Marika Collin Domenico Britti Achille P Caputi Christoph Thiemermann Source Type: research
Retraction notice to "Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody" [Clin. Immunol. 113/1 (2004) 64-73]
Clin Immunol. 2024 Mar 29:110197. doi: 10.1016/j.clim.2024.110197. Online ahead of print.NO ABSTRACTPMID:38555222 | DOI:10.1016/j.clim.2024.110197 (Source: Clinical Immunology)
Source: Clinical Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Rosanna Di Paola Roberto Di Marco Emanuela Mazzon Tiziana Genovese Klaus Bendtzen Battesimo Macri Ferdinando Nicoletti Salvatore Cuzzocrea Source Type: research
