Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis
Clin Immunol. 2023 Oct 23:109814. doi: 10.1016/j.clim.2023.109814. Online ahead of print.ABSTRACTIn Rheumatoid Arthritis (RA), regulatory T cells (Tregs) have been found to be enriched in the synovial fluid. Despite their accumulation, they are unable to suppress synovial inflammation. Recently, we showed the synovial enrichment of interleukin-9 (IL-9) producing helper T cells and its positive correlation with disease activity. Therefore, we investigated the impact of IL-9 on synovial Tregs in RA. Here, we confirmed high synovial Tregs in RA patients, however these cells were functionally impaired in terms of suppressive c...
Source: Clinical Immunology - October 25, 2023 Category: Allergy & Immunology Authors: Sushmita Chakraborty Ranjan Gupta Katharina F Kubatzky Santanu Kar Franziska V Kraus M Margarida Souto-Carneiro Hanns-Martin Lorenz Pankaj Kumar Vijay Kumar Dipendra Kumar Mitra Source Type: research
Oxidative stress is involved in immunosuppression and macrophage regulation in glioblastoma
Clin Immunol. 2023 Oct 20:109802. doi: 10.1016/j.clim.2023.109802. Online ahead of print.ABSTRACTOxidative stress dually affected cancer progression, while its effect on glioblastomas remained unclear. Herein, we clustered the multicenter glioblastoma cohorts based on the oxidative-stress-responsive genes (OSS) expression. We found that cluster 2 with high OSS levels suffered a worse prognosis. Functional analyses and immune-related analyses results exhibited that M2-like pro-tumoral macrophages and neutrophils were enriched in cluster 2, while Natural killer cells' infiltration was decreased. The increased M2-like pro-tum...
Source: Clinical Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Xisong Liang Zeyu Wang Ziyu Dai Jian Liu Hao Zhang Jie Wen Nan Zhang Jian Zhang Peng Luo Zaoqu Liu Zhixiong Liu Quan Cheng Source Type: research
Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis
Clin Immunol. 2023 Oct 20:109812. doi: 10.1016/j.clim.2023.109812. Online ahead of print.ABSTRACTSynovial fluid (SF) extracellular vesicles (EVs) play a pathogenic role in osteoarthritis (OA). However, the surface markers, cell and tissue origins, and effectors of these EVs are largely unknown. We found that SF EVs contained 692 peptides that were positively associated with knee radiographic OA severity; 57.4% of these pathogenic peptides were from 46 proteins of the immune system, predominantly the innate immune system. CSPG4, BGN, NRP1, and CD109 are the major surface markers of pathogenic SF EVs. Genes encoding surface ...
Source: Clinical Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Xin Zhang Sisi Ma Syeda Iffat Naz Vaibhav Jain Erik J Soderblom Constantin Aliferis Virginia Byers Kraus Source Type: research
Oxidative stress is involved in immunosuppression and macrophage regulation in glioblastoma
Clin Immunol. 2023 Oct 20:109802. doi: 10.1016/j.clim.2023.109802. Online ahead of print.ABSTRACTOxidative stress dually affected cancer progression, while its effect on glioblastomas remained unclear. Herein, we clustered the multicenter glioblastoma cohorts based on the oxidative-stress-responsive genes (OSS) expression. We found that cluster 2 with high OSS levels suffered a worse prognosis. Functional analyses and immune-related analyses results exhibited that M2-like pro-tumoral macrophages and neutrophils were enriched in cluster 2, while Natural killer cells' infiltration was decreased. The increased M2-like pro-tum...
Source: Clinical Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Xisong Liang Zeyu Wang Ziyu Dai Jian Liu Hao Zhang Jie Wen Nan Zhang Jian Zhang Peng Luo Zaoqu Liu Zhixiong Liu Quan Cheng Source Type: research
Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis
Clin Immunol. 2023 Oct 20:109812. doi: 10.1016/j.clim.2023.109812. Online ahead of print.ABSTRACTSynovial fluid (SF) extracellular vesicles (EVs) play a pathogenic role in osteoarthritis (OA). However, the surface markers, cell and tissue origins, and effectors of these EVs are largely unknown. We found that SF EVs contained 692 peptides that were positively associated with knee radiographic OA severity; 57.4% of these pathogenic peptides were from 46 proteins of the immune system, predominantly the innate immune system. CSPG4, BGN, NRP1, and CD109 are the major surface markers of pathogenic SF EVs. Genes encoding surface ...
Source: Clinical Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Xin Zhang Sisi Ma Syeda Iffat Naz Vaibhav Jain Erik J Soderblom Constantin Aliferis Virginia Byers Kraus Source Type: research
