Exploring the role of insulin-like growth factor binding protein-1 in identifying idiopathic multicentric Castleman's disease types: Implications for the mTOR signaling pathway
CONCLUSION: The mTOR pathway is suggested to be activated in iMCD-TAFRO compared to iMCD-NOS, which may elevate the protein IGFBP-1. This protein may be a biomarker to distinguish iMCD-TAFRO from iMCD-NOS.PMID:37778714 | DOI:10.1016/j.clim.2023.109798 (Source: Clinical Immunology)
Source: Clinical Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Remi Sumiyoshi Tomohiro Koga Shoichi Fukui Kaori Furukawa Mamiko Momoki Kunihiro Ichinose Shingo Yano Atsushi Kawakami Source Type: research

Exploring the role of insulin-like growth factor binding protein-1 in identifying idiopathic multicentric Castleman's disease types: Implications for the mTOR signaling pathway
CONCLUSION: The mTOR pathway is suggested to be activated in iMCD-TAFRO compared to iMCD-NOS, which may elevate the protein IGFBP-1. This protein may be a biomarker to distinguish iMCD-TAFRO from iMCD-NOS.PMID:37778714 | DOI:10.1016/j.clim.2023.109798 (Source: Clinical Immunology)
Source: Clinical Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Remi Sumiyoshi Tomohiro Koga Shoichi Fukui Kaori Furukawa Mamiko Momoki Kunihiro Ichinose Shingo Yano Atsushi Kawakami Source Type: research

Exploring the role of insulin-like growth factor binding protein-1 in identifying idiopathic multicentric Castleman's disease types: Implications for the mTOR signaling pathway
CONCLUSION: The mTOR pathway is suggested to be activated in iMCD-TAFRO compared to iMCD-NOS, which may elevate the protein IGFBP-1. This protein may be a biomarker to distinguish iMCD-TAFRO from iMCD-NOS.PMID:37778714 | DOI:10.1016/j.clim.2023.109798 (Source: Clinical Immunology)
Source: Clinical Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Remi Sumiyoshi Tomohiro Koga Shoichi Fukui Kaori Furukawa Mamiko Momoki Kunihiro Ichinose Shingo Yano Atsushi Kawakami Source Type: research

Exploring the role of insulin-like growth factor binding protein-1 in identifying idiopathic multicentric Castleman's disease types: Implications for the mTOR signaling pathway
CONCLUSION: The mTOR pathway is suggested to be activated in iMCD-TAFRO compared to iMCD-NOS, which may elevate the protein IGFBP-1. This protein may be a biomarker to distinguish iMCD-TAFRO from iMCD-NOS.PMID:37778714 | DOI:10.1016/j.clim.2023.109798 (Source: Clinical Immunology)
Source: Clinical Immunology - October 1, 2023 Category: Allergy & Immunology Authors: Remi Sumiyoshi Tomohiro Koga Shoichi Fukui Kaori Furukawa Mamiko Momoki Kunihiro Ichinose Shingo Yano Atsushi Kawakami Source Type: research

Th1/interferon- γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7
Clin Immunol. 2023 Sep 28;256:109793. doi: 10.1016/j.clim.2023.109793. Online ahead of print.ABSTRACTThe aim of this study was to investigate the impact of thymic dysplasia on the phenotypic and functional characteristics of T cells in patients with 22q11.2 deletion syndrome, including T-cell phenotype, transcriptional profile, cytokine production, as well as the possibility of utilizing IL-7 to recover their numbers and function. We found a strong bias towards Th1 response in pediatric and young adult 22q11.2DS patients, expansion of CXCR5+ follicular helper cells and CXCR3+CCR6- Th1 cells, increased production of cytokin...
Source: Clinical Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ondrej Vladyka Petra Vrabcova Michaela Reiterova Zuzana Parackova Robert Haesler Anna Sediva Tomas Kalina Adam Klocperk Source Type: research

Immune tolerance induced in the anterior chamber ameliorates corneal transplant rejection
Clin Immunol. 2023 Sep 28:109797. doi: 10.1016/j.clim.2023.109797. Online ahead of print.ABSTRACTThe relevance of regulatory T cells (Tregs) in induction of tolerance against corneal allografts has been well established. However, whether Tregs can be induced in the anterior chamber and suppress local alloimmune response after corneal transplantation is largely unknown. In the current study we report that not only can alloantigen specific Tregs be generated in the anterior chamber during corneal transplantation, they also play important roles in suppressing allograft rejection. Allograft rejected mice exhibit reduced Treg i...
Source: Clinical Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Jijun Sun Ting Wang Jiang Bian Weiyun Shi Qingguo Ruan Source Type: research

Th1/interferon- γ bias in 22q11.2 deletion syndrome is driven by memory T cells and exacerbated by IL-7
Clin Immunol. 2023 Sep 28:109793. doi: 10.1016/j.clim.2023.109793. Online ahead of print.ABSTRACTThe aim of this study was to investigate the impact of thymic dysplasia on the phenotypic and functional characteristics of T cells in patients with 22q11.2 deletion syndrome, including T-cell phenotype, transcriptional profile, cytokine production, as well as the possibility of utilizing IL-7 to recover their numbers and function. We found a strong bias towards Th1 response in pediatric and young adult 22q11.2DS patients, expansion of CXCR5+ follicular helper cells and CXCR3+CCR6- Th1 cells, increased production of cytokines I...
Source: Clinical Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ondrej Vladyka Petra Vrabcova Michaela Reiterova Zuzana Parackova Robert Haesler Anna Sediva Tomas Kalina Adam Klocperk Source Type: research

Immune tolerance induced in the anterior chamber ameliorates corneal transplant rejection
Clin Immunol. 2023 Sep 28:109797. doi: 10.1016/j.clim.2023.109797. Online ahead of print.ABSTRACTThe relevance of regulatory T cells (Tregs) in induction of tolerance against corneal allografts has been well established. However, whether Tregs can be induced in the anterior chamber and suppress local alloimmune response after corneal transplantation is largely unknown. In the current study we report that not only can alloantigen specific Tregs be generated in the anterior chamber during corneal transplantation, they also play important roles in suppressing allograft rejection. Allograft rejected mice exhibit reduced Treg i...
Source: Clinical Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Jijun Sun Ting Wang Jiang Bian Weiyun Shi Qingguo Ruan Source Type: research

Dysimmunity in common variable immunodeficiency is associated with alterations in oral, respiratory, and intestinal microbiota
In this study, we assessed the oral, respiratory, and gastrointestinal microbiota of 41 CVID patients (24 with dysimmune and 17 with infection complications) and 15 healthy volunteers using 16S rRNA gene sequencing to explore associations between microbiome profiles and CVID phenotypes. Profound differences in the composition of the microbiota in saliva, sputum, and stool were detected between dysimmune CVID patients and healthy individuals. Globally, respiratory species diversity and faecal bacterial richness were lower in CVID individuals with immune complications. Although a single species could not be identified as a r...
Source: Clinical Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Marta Dafne Cabanero-Navalon Victor Garcia-Bustos Alex Mira Pedro Moral Moral Miguel Salavert-Lleti Mar ía José Forner Giner Mar ía Núñez Beltrán Jos é Todolí Parra Carme Bracke Miguel Carda-Di éguez Source Type: research

Exploration of molecular signatures associated with different clinical features of Takayasu arteritis based on a prospective cohort study
Clin Immunol. 2023 Sep 27:109794. doi: 10.1016/j.clim.2023.109794. Online ahead of print.ABSTRACTTakayasu arteritis (TAK) is complicated disorder without reliable biomarkers. Here, we aimed to explore TAK-associated factor panels and their changes after biologic treatment. Five factor panels were identified: 1. systemic inflammation: C3, ESR, CRP, PLT, IL-6, C4, and IgG; 2. vascular inflammation: YKL40, IL-16, PTX3, and CCL2; 3. immune regulation panel: IL-10, IFN-γ, CCL5, and MMP1; 4. angiogenesis and fibrosis: FGF, PDGFAB, and VEGF; and 5. vascular remodeling: CD19+ B cell ratio, MMP3, and leptin. Panel 1 parameters wer...
Source: Clinical Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Xiufang Kong Jinghua Wang Rongyi Chen Ying Sun Huiyong Chen Lili Ma Lindi Jiang Source Type: research

Integrated analysis of tumour-derived exosome-related immune genes to predict progression and immune status of hepatocellular carcinoma
In conclusion, TIRGs are effective in predicting the prognosis of patients with hepatocellular carcinoma and provide a new perspective on immunotherapy and chemotherapy for patients.PMID:37774907 | DOI:10.1016/j.clim.2023.109774 (Source: Clinical Immunology)
Source: Clinical Immunology - September 29, 2023 Category: Allergy & Immunology Authors: Wenhua Li Bin Zhao Qianwen Wang Junxia Lu Xiangwei Wu Xueling Chen Source Type: research

Specific T-cell receptor beta-rearrangements of gluten-triggered CD8 < sup > + < /sup > T-cells are enriched in celiac disease patients' duodenal mucosa
Clin Immunol. 2023 Sep 26:109795. doi: 10.1016/j.clim.2023.109795. Online ahead of print.ABSTRACTCeliac disease (CeD) is an autoimmune disorder affecting the small intestine with gluten as disease trigger. Infections including Influenza A, increase the CeD risk. While gluten-specific CD4+ T-cells, recognizing HLA-DQ2/DQ8 presented gluten-peptides, initiate and sustain the celiac immune response, CD8+ α/β intraepithelial T-cells elicit mucosal damage. Here, we subjected TCRs from a cohort of 56 CeD patients and 22 controls to an analysis employing 749 published CeD-related TCRβ-rearrangements derived from gluten-specific...
Source: Clinical Immunology - September 28, 2023 Category: Allergy & Immunology Authors: V Seitz K Gennermann S Elezkurtaj D Groth S Schaper A Dr öge N Lachmann E Berg D Lenze A A K ühl C Husemann K Kleo D Horst V Lennerz S Hennig M Hummel M Schumann Source Type: research

The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps
This study highlights the deviated immune response and remodeling mechanisms that contribute to the pathogenesis of uncontrolled severe CRSwNP. CLINICAL IMPLICATIONS: We identified differences in the cellular compositions, transcriptomes, proteomes, and deviations in the immune profiles of T cell and B cell receptors as well as alterations in the intercellular communications in uncontrolled severe CRSwNP patients versus healthy controls, which might help to define potential therapeutic targets in the future.PMID:37769787 | DOI:10.1016/j.clim.2023.109791 (Source: Clinical Immunology)
Source: Clinical Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Zhaofeng Xu Yanran Huang Tim Meese Sharon Van Nevel Gabriele Holtappels Stijn Vanhee Barbara M Br öker Zhengqi Li Ellen de Meester Natalie De Ruyck Thibaut Van Zele Philip Gevaert Filip Van Nieuwerburgh Luo Zhang Mohamed H Shamji Weiping Wen Nan Zhang Cl Source Type: research

Specific T-cell receptor beta-rearrangements of gluten-triggered CD8 < sup > + < /sup > T-cells are enriched in celiac disease patients' duodenal mucosa
Clin Immunol. 2023 Sep 26:109795. doi: 10.1016/j.clim.2023.109795. Online ahead of print.ABSTRACTCeliac disease (CeD) is an autoimmune disorder affecting the small intestine with gluten as disease trigger. Infections including Influenza A, increase the CeD risk. While gluten-specific CD4+ T-cells, recognizing HLA-DQ2/DQ8 presented gluten-peptides, initiate and sustain the celiac immune response, CD8+ α/β intraepithelial T-cells elicit mucosal damage. Here, we subjected TCRs from a cohort of 56 CeD patients and 22 controls to an analysis employing 749 published CeD-related TCRβ-rearrangements derived from gluten-specific...
Source: Clinical Immunology - September 28, 2023 Category: Allergy & Immunology Authors: V Seitz K Gennermann S Elezkurtaj D Groth S Schaper A Dr öge N Lachmann E Berg D Lenze A A K ühl C Husemann K Kleo D Horst V Lennerz S Hennig M Hummel M Schumann Source Type: research

The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps
This study highlights the deviated immune response and remodeling mechanisms that contribute to the pathogenesis of uncontrolled severe CRSwNP. CLINICAL IMPLICATIONS: We identified differences in the cellular compositions, transcriptomes, proteomes, and deviations in the immune profiles of T cell and B cell receptors as well as alterations in the intercellular communications in uncontrolled severe CRSwNP patients versus healthy controls, which might help to define potential therapeutic targets in the future.PMID:37769787 | DOI:10.1016/j.clim.2023.109791 (Source: Clinical Immunology)
Source: Clinical Immunology - September 28, 2023 Category: Allergy & Immunology Authors: Zhaofeng Xu Yanran Huang Tim Meese Sharon Van Nevel Gabriele Holtappels Stijn Vanhee Barbara M Br öker Zhengqi Li Ellen de Meester Natalie De Ruyck Thibaut Van Zele Philip Gevaert Filip Van Nieuwerburgh Luo Zhang Mohamed H Shamji Weiping Wen Nan Zhang Cl Source Type: research