IKAROS expression drives the aberrant metabolic phenotype of macrophages in chronic HIV infection
Clin Immunol. 2024 Mar;260:109915. doi: 10.1016/j.clim.2024.109915. Epub 2024 Jan 28.ABSTRACTThe increased risk for acquiring secondary illnesses in people living with HIV (PLWH) has been associated with immune dysfunction. We have previously found that circulating monocytes from PLWH display a trained phenotype. Here, we evaluated the metabolic profile of these cells and found increased mitochondrial respiration and glycolysis of monocyte-derived macrophages (MDMs) from PLWH. We additionally found that cART shifted the energy metabolism of MDMs from controls toward increased utilization of mitochondrial respiration. Impor...
Source: Clinical Immunology - January 29, 2024 Category: Allergy & Immunology Authors: Cecilia Vittori Celeste Faia Dorota Wyczechowska Amber Trauth Karlie Plaisance-Bonstaff Mary Meyaski-Schluter Krzysztof Reiss Francesca Peruzzi Source Type: research
CD36 regulates macrophage and endothelial cell activation and multinucleate giant cell formation in anti neutrophil cytoplasm antibody vasculitis
CONCLUSION: CD36 participates in macrophage and endothelial cell activation and MNGC formation, features of AAV pathogenesis. AAV treatment may involve targeting CD36 or MIF.PMID:38286173 | DOI:10.1016/j.clim.2024.109914 (Source: Clinical Immunology)
Source: Clinical Immunology - January 29, 2024 Category: Allergy & Immunology Authors: Xiang Zhang Catherine King Alexander Dowell Paul Moss Lorraine Harper Dimitrios Chanouzas Xiong-Zhong Ruan Alan David Salama Source Type: research
Revisiting prostaglandin E2: A promising therapeutic target for osteoarthritis
Clin Immunol. 2024 Mar;260:109904. doi: 10.1016/j.clim.2024.109904. Epub 2024 Jan 21.ABSTRACTOsteoarthritis (OA) is a complex disease characterized by cartilage degeneration and persistent pain. Prostaglandin E2 (PGE2) plays a significant role in OA inflammation and pain. Recent studies have revealed the significant role of PGE2-mediated skeletal interoception in the progression of OA, providing new insights into the pathogenesis and treatment of OA. This aspect also deserves special attention in this review. Additionally, PGE2 is directly involved in pathologic processes including aberrant subchondral bone remodeling, car...
Source: Clinical Immunology - January 23, 2024 Category: Allergy & Immunology Authors: Dinglong Yang Ke Xu Xin Xu Peng Xu Source Type: research
The prevalence and incidence of thrombotic primary antiphospholipid syndrome in adults aged 18-49 years: A population-based study in a mountain community in northern Italy
CONCLUSIONS: Thrombotic PAPS was found to be a rare disease in this population-based study. Prevalence and incidence were not significantly different between males and females aged 18-49 years, but a different type of onset was observed.PMID:38246213 | DOI:10.1016/j.clim.2024.109905 (Source: Clinical Immunology)
Source: Clinical Immunology - January 21, 2024 Category: Allergy & Immunology Authors: Laura Andreoli Cecilia Nalli Elena Raffetti Fabrizio Angeli Greta Pascariello Arianna Zentilin Federica Pedersoli Cinzia Gasparotti Michele Magoni Carmelo Scarcella Giuliana Martini Franco Franceschini Francesco Donato Angela Tincani Source Type: research
Clinical presentation and outcomes in patients with antiphospholipid syndrome-associated adrenal hemorrhage. A multicenter cohort study and systematic literature review
CONCLUSION: AH is a severe manifestation of APS with increased mortality. Most patients developed permanent primary adrenal insufficiency, particularly those positive for anticardiolipin IgG and bilateral adrenal involvement.PMID:38244823 | DOI:10.1016/j.clim.2024.109906 (Source: Clinical Immunology)
Source: Clinical Immunology - January 20, 2024 Category: Allergy & Immunology Authors: Jos é A Meade-Aguilar Gabriel Figueroa-Parra Jeffrey X Yang Hannah E Langenfeld Mariana Gonz ález-Treviño Prerna Dogra Irina Bancos Michael R Moynagh M Hassan Murad Larry J Prokop Andrew C Hanson Cynthia S Crowson Al í Duarte-García Source Type: research
Corrigendum to "Intravitreal Dexamethasone Implants facilitate the management of Refractory Beh çet's Uveitis with vasculitis" [Clinical Immunology 251 (2023) 109633]
Clin Immunol. 2024 Feb;259:109893. doi: 10.1016/j.clim.2024.109893. Epub 2024 Jan 16.NO ABSTRACTPMID:38228441 | DOI:10.1016/j.clim.2024.109893 (Source: Clinical Immunology)
Source: Clinical Immunology - January 16, 2024 Category: Allergy & Immunology Authors: Tianyu Tao Shizhao Yang Daquan He Zhaohuai Li Binyao Chen Lei Zhu Wenru Su Source Type: research
Favipiravir induces HuNoV viral mutagenesis and infectivity loss with clinical improvement in immunocompromised patients
Clin Immunol. 2024 Feb;259:109901. doi: 10.1016/j.clim.2024.109901. Epub 2024 Jan 12.ABSTRACTChronic human norovirus (HuNoV) infections in immunocompromised patients result in severe disease, yet approved antivirals are lacking. RNA-dependent RNA polymerase (RdRp) inhibitors inducing viral mutagenesis display broad-spectrum in vitro antiviral activity, but clinical efficacy in HuNoV infections is anecdotal and the potential emergence of drug-resistant variants is concerning. Upon favipiravir (and nitazoxanide) treatment of four immunocompromised patients with life-threatening HuNoV infections, viral whole-genome sequencing...
Source: Clinical Immunology - January 13, 2024 Category: Allergy & Immunology Authors: Alexandra Y Kreins Emma Roux Juanita Pang Iek Cheng Oscar Charles Sunando Roy Reem Mohammed Stephen Owens David M Lowe Rossa Brugha Rachel Williams Evey Howley Timothy Best E Graham Davies Austen Worth Caroline Solas Joseph F Standing Richard A Goldstein Source Type: research
A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants
Clin Immunol. 2024 Mar;260:109902. doi: 10.1016/j.clim.2024.109902. Epub 2024 Jan 11.ABSTRACTThe devastating impact of COVID-19 on global health shows the need to increase our pandemic preparedness. Recombinant therapeutic antibodies were successfully used to treat and protect at-risk patients from COVID-19. However, the currently circulating Omicron subvariants of SARS-CoV-2 are largely resistant to therapeutic antibodies, and novel approaches to generate broadly neutralizing antibodies are urgently needed. Here, we describe a tetravalent bispecific antibody, A7A9 TVB, which actively neutralized many SARS-CoV-2 variants o...
Source: Clinical Immunology - January 13, 2024 Category: Allergy & Immunology Authors: Abhishek Chiyyeadu Girmay Asgedom Matthias Bruhn Cheila Rocha Tom U Schlegel Thomas Neumann Melanie Galla Philippe Vollmer Barbosa Markus Hoffmann Katrin Ehrhardt Teng-Cheong Ha Michael Morgan Clara T Schoeder Stefan P öhlmann Ulrich Kalinke Axel Schamba Source Type: research
Short-chain fatty acids ameliorate experimental anti-glomerular basement membrane disease
CONCLUSION: Treatment with SCFAs, especially butyrate, alleviated anti-GBM nephritis in rat model, indicating its potential therapeutic effects in clinical usage.PMID:38218211 | DOI:10.1016/j.clim.2024.109903 (Source: Clinical Immunology)
Source: Clinical Immunology - January 13, 2024 Category: Allergy & Immunology Authors: Jing Liu Qiu-Hua Gu Zhao Cui Ming-Hui Zhao Xiao-Yu Jia Source Type: research
Immune correlates with disease severity in older patients after SARS-CoV-2 BA.2 infection in Hong Kong
Clin Immunol. 2024 Feb;259:109900. doi: 10.1016/j.clim.2024.109900. Epub 2024 Jan 11.NO ABSTRACTPMID:38218212 | DOI:10.1016/j.clim.2024.109900 (Source: Clinical Immunology)
Source: Clinical Immunology - January 13, 2024 Category: Allergy & Immunology Authors: Na Liu Runhong Zhou Anthony Raymond Tam Wing-Ming Chu Dawei Yang Haode Huang Qiaoli Peng Zhenglong Du Bohao Chen Kelvin Kai-Wang To Zhiwei Chen Source Type: research
The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases
In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10-14), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu...
Source: Clinical Immunology - January 10, 2024 Category: Allergy & Immunology Authors: Hsing-Fang Lu Chen-Hsing Chou Ying-Ju Lin Shunsuke Uchiyama Chikashi Terao Yu-Wen Wang Jai-Sing Yang Ting-Yuan Liu Henry Sung-Ching Wong Sean Chun-Chang Chen Fuu-Jen Tsai Source Type: research
Chemotherapy for a secondary malignancy nearly restores complete chimerism in an SCID-patient after HSCT
We report on a boy with X-SCID who developed Ewing sarcoma ten years after HSCT which was successfully treated with cytoreductive chemotherapy, surgery and local radiation. Surprisingly, this treatment had a positive impact on mixed chimerism with an increase of donor-cell proportions from 40% for neutrophils and 75% for non-T-mononuclear cells (MNCs) to >90% for both. T-cell counts remained stable with 100% of donor origin. This is -to our knowledge- the first report on the impact of cytoreductive chemotherapy on post-HSCT mixed chimerism and provides an important first impression for future patients.PMID:38185266 | DO...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: Felix I Maier Ansgar Schulz Ingrid Furlan Kerstin Felgentreff Eva-Maria Jacobsen Mehtap Sirin Klaus Schwarz Ulrich Pannicke Jana Stursberg Klaus-Michael Debatin Manfred H önig Source Type: research
Th17 cell promotes apoptosis of IL-23R < sup > + < /sup > neurons in experimental autoimmune encephalomyelitis
Clin Immunol. 2024 Feb;259:109898. doi: 10.1016/j.clim.2024.109898. Epub 2024 Jan 5.ABSTRACTMyelin antigen-reactive Th1 and Th17 cells are critical drivers of central nervous system (CNS) autoimmune inflammation. Transcription factors T-bet and RORγt play a crucial role in the differentiation and function of Th1 and Th17 cells, and impart them a pathogenic role in CNS autoimmune inflammation. Mice deficient in these two factors do not develop experimental autoimmune encephalomyelitis (EAE). While T-bet and RORγt are known to regulate the expression of several cell adhesion and migratory molecules in T cells, their role i...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: Sandip Ashok Sonar Heikrujam Thoihen Meitei Surojit Karmakar Amrita Mishra Shrirang Inamdar Nibedita Lenka Girdhari Lal Source Type: research
Alterations in the innate and adaptive immune system in a real-world cohort of multiple sclerosis patients treated with ocrelizumab
Clin Immunol. 2024 Feb;259:109894. doi: 10.1016/j.clim.2024.109894. Epub 2024 Jan 6.ABSTRACTB cell depletion by the anti-CD20 antibody ocrelizumab is effective in relapsing-remitting (RR) and primary progressive (PP) multiple sclerosis (MS). We investigated immunological changes in peripheral blood of a real-world MS cohort after 6 and 12 months of ocrelizumab. All RRMS and most PPMS patients (15/20) showed treatment response. Ocrelizumab not only reduced CD20+ B cells, but also numbers of CD20+ T cells. Absolute numbers of monocytes, dendritic cells and CD8+ T cells were increased, while CD56hi natural killer cells were r...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: L Beckers P Baeten V Popescu D Swinnen A Cardilli I Hamad B Van Wijmeersch S J Tavernier M Kleinewietfeld B Broux J Fraussen V Somers Source Type: research
Guanylate binding protein 5 triggers NF- κB activation to foster radioresistance, metastatic progression and PD-L1 expression in oral squamous cell carcinoma
Clin Immunol. 2024 Feb;259:109892. doi: 10.1016/j.clim.2024.109892. Epub 2024 Jan 5.ABSTRACTRadioresistance and metastasis are critical issues in managing oral squamous cell carcinoma (OSCC). Although immune checkpoint inhibitors (ICIs) has been recommended to treat OSCC, lacking useful biomarkers limited their anti-cancer effectiveness. We found that guanylate binding protein 5 (GBP5) is upregulated in primary tumors and associates with radioresistance in OSCC. GBP5 expression causally associated with cellular radioresistance and migration ability in the OSCC cell variants. GBP5 upregulation was examined to be correlated ...
Source: Clinical Immunology - January 7, 2024 Category: Allergy & Immunology Authors: Hui-Wen Chiu Che-Hsuan Lin Hsun-Hua Lee Hsiao-Wei Lu Yu-Hsien Kent Lin Yuan-Feng Lin Hsin-Lun Lee Source Type: research
