Presence of ectopic germinal center structures in autoimmune hepatitis
Clin Immunol. 2023 Dec 23:109876. doi: 10.1016/j.clim.2023.109876. Online ahead of print.ABSTRACTAutoimmune tissues may contain ectopic germinal centers (EGCs). However, these structures have never been described in the liver of patients suffering from autoimmune hepatitis (AIH). We retrospectively reviewed histological features of 120 definite AIH cases, and found 10 cases harboring markers of EGCs. In these cases, CD21+ follicular dendritic cells were intermixed with CD3+ T and CD20+ B lymphocytes. The latter expressed the GC-specific markers bcl6 and some were proliferative as assessed by Ki67 expression. Antibody-secre...
Source: Clinical Immunology - December 25, 2023 Category: Allergy & Immunology Authors: B Huard Chemkhi Zeineb D Giovannini M Barre A Baillet D Cornec K Harada N Sturm Source Type: research
AIM2 inflammasome: A potential therapeutic target in ischemic stroke
Clin Immunol. 2023 Dec 22:109881. doi: 10.1016/j.clim.2023.109881. Online ahead of print.ABSTRACTIschemic stroke (IS) is a significant global public health issue with a high incidence, disability, and mortality rate. A robust inflammatory cascade with complex and wide-ranging mechanisms occurs following ischemic brain injury. Inflammasomes are multiprotein complexes in the cytoplasm that modulate the inflammatory response by releasing pro-inflammatory cytokines and inducing cellular pyroptosis. Among these inflammasomes, the Absent in Melanoma 2 (AIM2) inflammasome shows the ability to detect a wide range of pathogen DNAs,...
Source: Clinical Immunology - December 24, 2023 Category: Allergy & Immunology Authors: Rong Fu Linna Zhao Yuying Guo Xiaoli Qin Wenzhe Xu Xueqi Cheng Yunsha Zhang Shixin Xu Source Type: research
Clinical outcome and peripheral immune profile of myasthenic crisis with omicron infections: A prospective cohort study
Clin Immunol. 2023 Dec 22:109879. doi: 10.1016/j.clim.2023.109879. Online ahead of print.ABSTRACTThe impact of Omicron infections on the clinical outcome and immune responses of myasthenia gravis (MG) remained largely unknown. From a prospective multicenter MG cohort (n = 189) with 197 myasthenic crisis (MC), we finally included 41 independent MG patients to classify into two groups: the Omicron Group (n = 13) and the Control Group (n = 28). In this matched cohort study, all-cause mortality was 7.69% (1/13) in Omicron Group and 14.29% (4/28) in Control Group. A higher proportion of elevated serum IL-6 was identified in the...
Source: Clinical Immunology - December 24, 2023 Category: Allergy & Immunology Authors: Xiao Huan Jialin Chen Huahua Zhong Yafang Xu Yuan Wang Haoqin Jiang Jie Song Chong Yan Jianying Xi Zhangyu Zou Jianming Zheng Zhe Ruan Song Tan Lijun Luo Sushan Luo Chongbo Zhao Pan-Yangtze River Delta Alliance for Neuromuscular Disorders (PYDAN) Li Zeng Source Type: research
ProBDNF contributed to patrolling monocyte infiltration and renal damage in systemic lupus erythematosus
Clin Immunol. 2023 Dec 22:109880. doi: 10.1016/j.clim.2023.109880. Online ahead of print.ABSTRACTMonocyte aberrations have been increasingly recognized as contributors to renal damage in systemic lupus erythematosus (SLE), however, recognition of the underlying mechanisms and modulating strategies is at an early stage. Our studies have demonstrated that brain-derived neurotrophic factor precursor (proBDNF) drives the progress of SLE by perturbing antibody-secreting B cells, and proBDNF facilitates pro-inflammatory responses in monocytes. By utilizing peripheral blood from patients with SLE, GEO database and spontaneous MRL...
Source: Clinical Immunology - December 24, 2023 Category: Allergy & Immunology Authors: Cong Luo An-Hui Zha Ru-Yi Luo Zhao-Lan Hu Wei-Yun Shen Ru-Ping Dai Source Type: research
Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response
In this study, we measured inflammatory cytokine concentration and SARS-CoV-2-specific humoral immunity and T cell responses in children with fever and suspected MIS-C at presentation (n = 83) where MIS-C was ultimately confirmed (n = 58) or another diagnosis was made (n = 25) and healthy children (n = 91). Children with confirmed MIS-C exhibited distinctly elevated serum IL-10, IL-6, and CRP at presentation. No differences were detected in SARS-CoV-2 spike IgG serum concentration, neutralisation capacity, antibody dependant cellular phagocytosis, antibody dependant cellular cytotoxicity or SARS-CoV-2-specific T cell frequ...
Source: Clinical Immunology - December 23, 2023 Category: Allergy & Immunology Authors: Claire Butters Ntombi Benede Thandeka Moyo-Gwete Simone I Richardson Ursula Rohlwink Muki Shey Frances Ayres Nelia P Manamela Zanele Makhado Sashkia R Balla Mashudu Madzivhandila Amkele Ngomti Richard Baguma Heidi Facey-Thomas Timothy F Spracklen Jonathan Source Type: research
Renal dysfunction in AQP4 NMOSD and MS; a potential predictor of relapse and prognosis
CONCLUSIONS: The eGFR of patients with AQP4-IgG-seropositive NMOSD emerges as a potential diagnostic biomarker for this condition, indicating its significance in predicting both relapse risk and clinical prognosis.PMID:38141747 | DOI:10.1016/j.clim.2023.109875 (Source: Clinical Immunology)
Source: Clinical Immunology - December 23, 2023 Category: Allergy & Immunology Authors: Yongkang Chen Yilin Wang Ruoqi Jin Zheng Lv Yu Fu Junfang Teng Xuejing Wang Source Type: research
Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response
In this study, we measured inflammatory cytokine concentration and SARS-CoV-2-specific humoral immunity and T cell responses in children with fever and suspected MIS-C at presentation (n = 83) where MIS-C was ultimately confirmed (n = 58) or another diagnosis was made (n = 25) and healthy children (n = 91). Children with confirmed MIS-C exhibited distinctly elevated serum IL-10, IL-6, and CRP at presentation. No differences were detected in SARS-CoV-2 spike IgG serum concentration, neutralisation capacity, antibody dependant cellular phagocytosis, antibody dependant cellular cytotoxicity or SARS-CoV-2-specific T cell frequ...
Source: Clinical Immunology - December 23, 2023 Category: Allergy & Immunology Authors: Claire Butters Ntombi Benede Thandeka Moyo-Gwete Simone I Richardson Ursula Rohlwink Muki Shey Frances Ayres Nelia P Manamela Zanele Makhado Sashkia R Balla Mashudu Madzivhandila Amkele Ngomti Richard Baguma Heidi Facey-Thomas Timothy F Spracklen Jonathan Source Type: research
Renal dysfunction in AQP4 NMOSD and MS; a potential predictor of relapse and prognosis
CONCLUSIONS: The eGFR of patients with AQP4-IgG-seropositive NMOSD emerges as a potential diagnostic biomarker for this condition, indicating its significance in predicting both relapse risk and clinical prognosis.PMID:38141747 | DOI:10.1016/j.clim.2023.109875 (Source: Clinical Immunology)
Source: Clinical Immunology - December 23, 2023 Category: Allergy & Immunology Authors: Yongkang Chen Yilin Wang Ruoqi Jin Zheng Lv Yu Fu Junfang Teng Xuejing Wang Source Type: research
Comment on Narsale et al. Th2 cell clonal expansion at diagnosis in human type 1 diabetes. Clin Immunol. 2023 Oct 29
Clin Immunol. 2023 Dec 18;258:109873. doi: 10.1016/j.clim.2023.109873. Online ahead of print.NO ABSTRACTPMID:38122839 | DOI:10.1016/j.clim.2023.109873 (Source: Clinical Immunology)
Source: Clinical Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Marcelo Maia Pinheiro Felipe Moura Maia Pinheiro Susana Nogueira Diniz Source Type: research
The spectrum of side effects associated with COVID-19 vaccines in patients with inborn errors of immunity
CONCLUSION: IEI-P mRNA vaccination is relatively safe compared to the conventional vaccine. Individuals who experience uncommon side effects should undergo immunological screening.PMID:38122840 | DOI:10.1016/j.clim.2023.109878 (Source: Clinical Immunology)
Source: Clinical Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Cansu Özdemiral Nadira Nabiyeva Cevik Gizem Yavuz Onuralp Gormez Ayse Bet ül Zengin Saliha Esenboga Erdem Karabulut Deniz Cagdas Source Type: research
Comment on Narsale et al. Th2 cell clonal expansion at diagnosis in human type 1 diabetes. Clin Immunol. 2023 Oct 29
Clin Immunol. 2023 Dec 18;258:109873. doi: 10.1016/j.clim.2023.109873. Online ahead of print.NO ABSTRACTPMID:38122839 | DOI:10.1016/j.clim.2023.109873 (Source: Clinical Immunology)
Source: Clinical Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Marcelo Maia Pinheiro Felipe Moura Maia Pinheiro Susana Nogueira Diniz Source Type: research
The spectrum of side effects associated with COVID-19 vaccines in patients with inborn errors of immunity
CONCLUSION: IEI-P mRNA vaccination is relatively safe compared to the conventional vaccine. Individuals who experience uncommon side effects should undergo immunological screening.PMID:38122840 | DOI:10.1016/j.clim.2023.109878 (Source: Clinical Immunology)
Source: Clinical Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Cansu Özdemiral Nadira Nabiyeva Cevik Gizem Yavuz Onuralp Gormez Ayse Bet ül Zengin Saliha Esenboga Erdem Karabulut Deniz Cagdas Source Type: research
Comment on Narsale et al. Th2 cell clonal expansion at diagnosis in human type 1 diabetes. Clin Immunol. 2023 Oct 29
Clin Immunol. 2023 Dec 18:109873. doi: 10.1016/j.clim.2023.109873. Online ahead of print.NO ABSTRACTPMID:38122839 | DOI:10.1016/j.clim.2023.109873 (Source: Clinical Immunology)
Source: Clinical Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Marcelo Maia Pinheiro Felipe Moura Maia Pinheiro Susana Nogueira Diniz Source Type: research
The spectrum of side effects associated with COVID-19 vaccines in patients with inborn errors of immunity
CONCLUSION: IEI-P mRNA vaccination is relatively safe compared to the conventional vaccine. Individuals who experience uncommon side effects should undergo immunological screening.PMID:38122840 | DOI:10.1016/j.clim.2023.109878 (Source: Clinical Immunology)
Source: Clinical Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Cansu Özdemiral Nadira Nabiyeva Cevik Gizem Yavuz Onuralp Gormez Ayse Bet ül Zengin Saliha Esenboga Erdem Karabulut Deniz Cagdas Source Type: research
Fas < sup > lpr < /sup > gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus
Clin Immunol. 2023 Dec 17:109874. doi: 10.1016/j.clim.2023.109874. Online ahead of print.ABSTRACTSle1 and Faslpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus. To evaluate the dosage effects of Faslpr in determining cellular and serological phenotypes associated with lupus, we developed a new C57BL/6 (B6) congenic lupus strain, B6.Sle1/Sle1.Faslpr/+ (Sle1homo.lprhet) and compared it with B6.Faslpr/lpr (lprhomo), B6.Sle1/Sle1 (Sle1homo), and B6.Sle1/Sle1.Faslpr/lpr (Sle1homo.lprhomo) strains. Whereas Sle1homo.lprhomo mice exhibited profound lymphoproliferation and early mortal...
Source: Clinical Immunology - December 19, 2023 Category: Allergy & Immunology Authors: Ritu Bohat Xiaofang Liang Yanping Chen Chunyu Xu Ningbo Zheng Ashley Guerrero Jiakai Hou Roshni Jaffery Nicholas A Egan Yaxi Li Yitao Tang Esra Unsal Adolfo Robles Si Chen Angela M Major Hadil Elldakli Sang-Hyuk Chung Han Liang M John Hicks Yong Du Jamie Source Type: research
