Changes in mucosal IgG4 < sup > + < /sup > - and IL-10 < sup > + < /sup > -cell frequencies in adults with eosinophilic esophagitis on a two-food elimination diet

Clin Immunol. 2023 Nov 25:109853. doi: 10.1016/j.clim.2023.109853. Online ahead of print.ABSTRACTEosinophilic esophagitis (EoE) is increasingly diagnosed in patients with dysphagia. Type-2 immunity can induce EoE histopathology via non-IgE-dependent mechanisms, possibly involving IgG4 and IL-10. To elucidate the contribution of this response to EoE pathogenesis, we examined its association with clinical and histologic endpoints in adult EoE patients given a two-food elimination diet. IgG4- and IL-10-expressing cells were counted in esophageal biopsies and serum food-specific IgG4 measured at baseline and follow-up. Variables were correlated with histologic measures of disease activity. Patients exhibited significant reduction in esophageal eosinophilia and overall histology. A significant decrease in IL-10+-cell frequencies correlated with histologic changes. In contrast, a decline in serum and esophageal IgG4, while substantial, did not correlate with IL-10+-cell frequencies or histologic parameters. These results suggest a critical role of IL-10 in EoE pathogenesis. Conversely, IgG4 expression, while reflecting exposure to food antigens, is not obviously related to EoE histopathology or IL-10 expression.PMID:38013163 | DOI:10.1016/j.clim.2023.109853
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research