Changes in mucosal IgG4 < sup > + < /sup > - and IL-10 < sup > + < /sup > -cell frequencies in adults with eosinophilic esophagitis on a two-food elimination diet
Clin Immunol. 2023 Nov 25:109853. doi: 10.1016/j.clim.2023.109853. Online ahead of print.ABSTRACTEosinophilic esophagitis (EoE) is increasingly diagnosed in patients with dysphagia. Type-2 immunity can induce EoE histopathology via non-IgE-dependent mechanisms, possibly involving IgG4 and IL-10. To elucidate the contribution of this response to EoE pathogenesis, we examined its association with clinical and histologic endpoints in adult EoE patients given a two-food elimination diet. IgG4- and IL-10-expressing cells were counted in esophageal biopsies and serum food-specific IgG4 measured at baseline and follow-up. Variables were correlated with histologic measures of disease activity. Patients exhibited significant reduction in esophageal eosinophilia and overall histology. A significant decrease in IL-10+-cell frequencies correlated with histologic changes. In contrast, a decline in serum and esophageal IgG4, while substantial, did not correlate with IL-10+-cell frequencies or histologic parameters. These results suggest a critical role of IL-10 in EoE pathogenesis. Conversely, IgG4 expression, while reflecting exposure to food antigens, is not obviously related to EoE histopathology or IL-10 expression.PMID:38013163 | DOI:10.1016/j.clim.2023.109853
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Ramapraba Appanna Domenico Gargano Alessandro Caputo Fabio De Bartolomeis Luca Ricciardi Antonella Santonicola Berenice Stefanelli Laura Caiazza Marialuisa Guarciariello Antonio D'Antonio Raffaella D'Auria Valeria Conti Vincenzo Casolaro Paola Iovino Source Type: research