Recent advances in the involvement of epigenetics in the pathogenesis of systemic lupus erythematosus

Clin Immunol. 2023 Dec 1:109857. doi: 10.1016/j.clim.2023.109857. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a typical systemic autoimmune disease that manifests as skin rash, arthritis, lymphadenopathy, and multiple organ lesions. Epigenetics, including DNA methylation, histone modification, and non-coding RNA regulation, mainly affect the function and characteristics of cells through the regulation of gene transcription or translation. Increasing evidence indicates that there are a variety of complex epigenetic effects in patients with SLE, which interfere with the differentiation and function of T, and B lymphocytes, monocytes, and neutrophils, and enhance the expression of SLE-associated pathogenic genes. This paper summarizes our currently knowledge regarding pathogenesis of SLE, and introduces current advances in the epigenetic regulation of SLE from three aspects: immune function, inflammatory response, and lupus complications. We propose that epigenetic changes could be used as potential biomarkers and therapeutic targets of SLE.PMID:38043757 | DOI:10.1016/j.clim.2023.109857
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research