Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

IL-21, Not IL-17A, Exacerbates Murine Primary Biliary Cholangitis
In this study, we investigated the effects of Th17 effector cytokines, including interleukin (IL)-17A, IL-17F, and IL-21 in PBC using a xenobiotic-induced mouse model of autoimmune cholangitis (inducible chemical xenobiotic models of PBC) treated with cytokine-expressing adeno-associated virus. Our results showed that administration of IL-17A, the well-known main cytokine produced by Th17 cells, did not augment liver inflammation or fibrosis. In contrast, we noted IL-17A-treated mice had lower hepatic Th1 cell numbers and higher hepatic CD11b +Ly6G + polymorphonuclear myeloid-derived suppressor cell numbers. IL-17F did not...
Source: Clinical and Developmental Immunology - September 14, 2023 Category: Allergy & Immunology Authors: Chun-Wen Chan Hung-Wen Chen Yu-Wen Wang Chia-I Lin Ya-Hui Chuang Source Type: research

Toxicity spectrum and risk factors for chemo-immunotherapy in locally advanced or metastatic lung cancer
Clin Exp Immunol. 2023 Sep 11:uxad105. doi: 10.1093/cei/uxad105. Online ahead of print.ABSTRACTChemo-immunotherapy has become the best first-line treatment for advanced lung cancer patients without oncogenic drivers. However, it may also lead to an increased incidence and severity of treatment-related adverse events. In this retrospective study, lung cancer patients administrated with either anti-PD-1 or anti-PD-L1 treatment plus chemotherapy were included. Data on demographic characteristics, disease characteristics, treatment strategies, laboratory results and clinical outcomes were collected from the Electronic Medical ...
Source: Clinical and Developmental Immunology - September 11, 2023 Category: Allergy & Immunology Authors: Jinjin Li Wenhao Shi Jin Xiong Yusheng Huang Yi He Yan Zhou Zhenzhou Yang Yuan Peng Source Type: research

Neutrophil extracellular traps are involved in the occurrence of interstitial lung disease in a murine experimental autoimmune myositis model
This study aimed to answer whether an experimental autoimmune myositis (EAM) model can be used to study IIM-ILD and whether NETs participate in the development of EAM-ILD. An EAM mouse model was established using skeletal muscle homogenate and pertussis toxin (PTX). The relationship between NETs and the ILD phenotype was determined via histopathological analysis. As NETs markers, serum cell-free DNA (cfDNA) and serum citrullinated histone 3 (Cit-H3)-DNA were tested. Healthy mouse was injected with PTX intraperitoneally to determine whether PTX intervention could induce NETs formation in vivo. Neutrophils isolated from the ...
Source: Clinical and Developmental Immunology - September 8, 2023 Category: Allergy & Immunology Authors: Ling Bai Jiarui Zhu Wenlan Ma Feifei Li Peipei Zhao Sigong Zhang Source Type: research

Disease Activity in Chronic Inflammatory Demyelinating Polyneuropathy: Association Between Circulating B Cell Subsets, Cytokine Levels and Clinical Outcomes
DISCUSSION: Altered B-cell homeostasis and IL10 and TNFA gene expression levels imply chronic antigen exposure and overactivity in humoral immune system, and seem to be a common pathological pathway in both typical CIDP and CIDP variants.PMID:37638717 | DOI:10.1093/cei/uxad103 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Ayse Nur Ozdag Acarli Erdem Tuzun Elif Sanli Gizem Koral Ece Akbayir Arman Cakar Nermin Gorkem Sirin Aysun Soysal Fikret Aysal Hacer Durmus Yesim Parman Vuslat Yilmaz Source Type: research