Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research

Gender-affirming hormone therapy and autoimmunity: new insights from a three-year follow-up study
Clin Exp Immunol. 2023 Nov 14:uxad122. doi: 10.1093/cei/uxad122. Online ahead of print.NO ABSTRACTPMID:37962550 | DOI:10.1093/cei/uxad122 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - November 14, 2023 Category: Allergy & Immunology Authors: Matteo Marconi Gloria Riitano Alessandra Daphne Fisher Carlotta Cocchetti Maria Teresa Pagano Antonella Capozzi Agostina Longo Sara D'Arienzo Linda Vignozzi Maurizio Sorice Elena Ortona Marina Pierdominici Source Type: research

The CXCL10-CXCR3 axis plays an important role in Kawasaki Disease
Clin Exp Immunol. 2023 Nov 11:uxad125. doi: 10.1093/cei/uxad125. Online ahead of print.ABSTRACTThe precise pathogenesis of Kawasaki Disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immunity, we comprehensively examined the immunophenotypic changes in immune cells such as lymphocytes and monocytes along with various cytokines, focusing on differences between pre- and post- treatment samples. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of Th1 cells expressing CXCR3. Our results sho...
Source: Clinical and Developmental Immunology - November 12, 2023 Category: Allergy & Immunology Authors: Sho Hosaka Kazuo Imagawa Yusuke Yano Lisheng Lin Junko Shiono Miho Takahashi-Igari Hideki Hara Daisuke Hayashi Hironori Imai Atsushi Morita Hiroko Fukushima Hidetoshi Takada Source Type: research

CD3 downregulation identifies high-avidity human CD8 T cells
Clin Exp Immunol. 2023 Nov 9:uxad124. doi: 10.1093/cei/uxad124. Online ahead of print.ABSTRACTCD8 T cells recognize infected and cancerous cells via their T cell receptor (TCR), which binds peptide-MHC complexes on the target cell. The affinity of the interaction between the TCR and peptide-MHC contributes to the antigen sensitivity, or functional avidity, of the CD8 T cell. In response to peptide-MHC stimulation, the TCR-CD3 complex and CD8 co-receptor are downmodulated. We quantified CD3 and CD8 downmodulation following stimulation of human CD8 T cells with CMV, EBV, and HIV peptides spanning eight MHC restrictions, obse...
Source: Clinical and Developmental Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Genevieve T Clutton Ann Marie K Weideman Melissa A Mischell Sallay Kallon Shayla Z Conrad Fiona R Shaw Joanna Warren Lin Lin JoAnn D Kuruc Yinyan Xu Cynthia Gay Paul M Armistead Michael Hudgens Nilu P Goonetilleke Source Type: research

Plasma circulating microRNAs associated with blood-based immune markers: a population-based study
In this study we aimed to investigate the association of circulating miRNAs with blood cell compositions and blood-based immune markers. Circulating levels of 2083 miRNAs were measured by RNA-sequencing in plasma samples of 1999 participants from the population-based Rotterdam Study collected between 2002 and 2005. Full blood count measurements were performed for absolute granulocyte, platelet, lymphocyte, monocyte, white and red blood cell counts. Multivariate analyses were performed to test the association of miRNAs with blood cell compositions and immune markers. We evaluated the overlap between predicted target genes o...
Source: Clinical and Developmental Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Samantha Leonard Irma Karabegovi ć M Arfan Ikram Shahzad Ahmad Mohsen Ghanbari Source Type: research

Transcriptome profiling of regulatory T cells from children with Transient Hypogammaglobulinemia of Infancy
Clin Exp Immunol. 2023 Nov 4:uxad116. doi: 10.1093/cei/uxad116. Online ahead of print.ABSTRACTTransient Hypogammaglobulinemia of Infancy (THI) is one of the most common forms of hypogammaglobulinemia in the early childhood. THI is usually associated with chronic, recurrent bacterial and viral infections, life-threatening in some cases, yet its pathogenesis is still largely unknown. Since our previous findings indicated the possible role of Treg cells in the pathomechanism of THI, the aim of the current study was to investigate gene expression profile of Treg cells isolated from THI patients. The transcriptome-wide gene pro...
Source: Clinical and Developmental Immunology - November 8, 2023 Category: Allergy & Immunology Authors: Magdalena Rutkowska-Zapa ła Agnieszka Grabowska Marzena Lenart Anna Kluczewska Anna Szaflarska Krzysztof Kobylarz Anna Pituch-Noworolska Maciej Siedlar Source Type: research

Tuning the potency and selectivity of ImmTAC molecules by affinity modulation
Clin Exp Immunol. 2023 Nov 1:uxad120. doi: 10.1093/cei/uxad120. Online ahead of print.ABSTRACTT cell engaging bispecifics have great clinical potential for the treatment of cancer and infectious diseases. The binding affinity and kinetics of a bispecific molecule for both target and T cell CD3 have substantial effects on potency and specificity, but the rules governing these relationships are not fully understood. Using ImmTAC (Immune mobilizing monoclonal TCRs Against Cancer) molecules as a model, we explored the impact of altering affinity for target and CD3 on the potency and specificity of the re-directed T cell respon...
Source: Clinical and Developmental Immunology - November 6, 2023 Category: Allergy & Immunology Authors: Ian B Robertson Rachel Mulvaney Nele Dieckmann Alessio Vantellini Martina Canestraro Francesca Amicarella Ronan O'Dwyer David K Cole Stephen Harper Omer Dushek Peter Kirk Source Type: research