Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Regulatory T Cells in Inflamed Liver are Dysfunctional in Murine Primary Biliary Cholangitis
In conclusion, the function of Tregs in the inflamed liver of PBC was insufficient, and low-dose IL-2 treatment could not restore their function to suppress pathological immune responses. Transferring normal Tregs or directly targeting effector CD8 T cells may be beneficial for treating PBC.PMID:37916967 | DOI:10.1093/cei/uxad117 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - November 2, 2023 Category: Allergy & Immunology Authors: Chia-I Lin Yu-Wen Wang Chih-Yu Liu Hung-Wen Chen Pi-Hui Liang Ya-Hui Chuang Source Type: research

Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis
Clin Exp Immunol. 2023 Oct 31:uxad119. doi: 10.1093/cei/uxad119. Online ahead of print.ABSTRACTPatients with decompensated liver cirrhosis, in particular those classified as Childs-Pugh class C, are at increased risk of severe COVID-19 upon infection with SARS-CoV-2. The biological mechanisms underlying this are unknown. We aimed to examine the levels of serum intrinsic antiviral proteins as well as alterations in the innate antiviral immune response in patients with decompensated liver cirrhosis. Serum from 53 SARS-CoV-2 unexposed and unvaccinated individuals, with decompensated liver cirrhosis undergoing assessment for l...
Source: Clinical and Developmental Immunology - November 2, 2023 Category: Allergy & Immunology Authors: Gordon Greville Sinead Cremen Shauna O'Neill Sarah Azarian Gareth Brady William McCormack Adam H Dyer Nollaig M Bourke Olivier Touzelet David Courtney Ultan F Power Paul Dowling Tom K Gallagher Connor G G Bamford Mark W Robinson Source Type: research

Valganciclovir modulates the TNF axis molecules expression and CD4+ T cell subsets in disseminated Kaposi Sarcoma patients
In conclusion, VGC, as an add-on therapy in DKS/HIV patients, gradually modulates the activation of CD4+ T cell subsets and the TNF/TNFRs axis, suggesting a better regulation of the inflammatory status.PMID:37904542 | DOI:10.1093/cei/uxad115 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Lucero A Ramon-Luing Julio Flores-Gonzalez Luis Angel Garc ía-Rojas Beda Islas-Mu ñoz Patricia Volkow-Fern ández Leslie Chavez-Galan Source Type: research

Time to treat the climate and nature crisis as one indivisible global health emergency †
Clin Exp Immunol. 2023 Oct 25:uxad111. doi: 10.1093/cei/uxad111. Online ahead of print.NO ABSTRACTPMID:37880176 | DOI:10.1093/cei/uxad111 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - October 25, 2023 Category: Allergy & Immunology Authors: Kamran Abbasi Parveen Ali Virginia Barbour Thomas Benfield Kirsten Bibbins-Domingo Stephen Hancocks Richard Horton Laurie Laybourn-Langton Robert Mash Peush Sahni Wadeia Mohammad Sharief Paul Yonga Chris Zielinski Source Type: research

Cultured lymphocytes' mitochondrial genome integrity is not altered by cladribine
Clin Exp Immunol. 2023 Oct 20:uxad112. doi: 10.1093/cei/uxad112. Online ahead of print.ABSTRACTCladribine tablets are a treatment for multiple sclerosis with effects on lymphocytes, yet its mode of action has not been fully established. Here, we analyzed the effects of cladribine on mitochondrial DNA integrity in lymphocytes. We treated cultured human T-cell lines (CCRF-CEM and Jurkat) with varying concentrations of cladribine to mimic the slow cell depletion observed in treated patients. The CCRF-CEM was more susceptible to cladribine than Jurkat cells. In both cells mitochondrial protein synthesis, mitochondrial DNA copy...
Source: Clinical and Developmental Immunology - October 20, 2023 Category: Allergy & Immunology Authors: Elina J ärvinen Fumi Suomi James B Stewart Dimitri Guala Miko Valori Lilja Jansson Janne Nieminen Thomas G McWilliams Pentti J Tienari Source Type: research

Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis
Clin Exp Immunol. 2023 Oct 17:uxad106. doi: 10.1093/cei/uxad106. Online ahead of print.ABSTRACTTranslocation of gut bacteria into the pancreas promotes the development of severe acute pancreatitis (SAP). Recent clinical studies have also highlighted the association between fungal infections and SAP. The sensing of gut bacteria by pattern recognition receptors promotes the development of SAP via the production of proinflammatory cytokines; however, the mechanism by which gut fungi mediate SAP remains largely unknown. Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that regulates innate immunity against fun...
Source: Clinical and Developmental Immunology - October 17, 2023 Category: Allergy & Immunology Authors: Yasuo Otsuka Akane Hara Kosuke Minaga Ikue Sekai Masayuki Kurimoto Yasuhiro Masuta Ryutaro Takada Tomoe Yoshikawa Ken Kamata Masatoshi Kudo Tomohiro Watanabe Source Type: research