Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Plasma circulating microRNAs associated with blood-based immune markers: a population-based study
In this study we aimed to investigate the association of circulating miRNAs with blood cell compositions and blood-based immune markers. Circulating levels of 2083 miRNAs were measured by RNA-sequencing in plasma samples of 1999 participants from the population-based Rotterdam Study collected between 2002 and 2005. Full blood count measurements were performed for absolute granulocyte, platelet, lymphocyte, monocyte, white and red blood cell counts. Multivariate analyses were performed to test the association of miRNAs with blood cell compositions and immune markers. We evaluated the overlap between predicted target genes o...
Source: Clinical and Developmental Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Samantha Leonard Irma Karabegovi ć M Arfan Ikram Shahzad Ahmad Mohsen Ghanbari Source Type: research

CD3 downregulation identifies high-avidity human CD8 T cells
Clin Exp Immunol. 2023 Nov 9:uxad124. doi: 10.1093/cei/uxad124. Online ahead of print.ABSTRACTCD8 T cells recognize infected and cancerous cells via their T cell receptor (TCR), which binds peptide-MHC complexes on the target cell. The affinity of the interaction between the TCR and peptide-MHC contributes to the antigen sensitivity, or functional avidity, of the CD8 T cell. In response to peptide-MHC stimulation, the TCR-CD3 complex and CD8 co-receptor are downmodulated. We quantified CD3 and CD8 downmodulation following stimulation of human CD8 T cells with CMV, EBV, and HIV peptides spanning eight MHC restrictions, obse...
Source: Clinical and Developmental Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Genevieve T Clutton Ann Marie K Weideman Melissa A Mischell Sallay Kallon Shayla Z Conrad Fiona R Shaw Joanna Warren Lin Lin JoAnn D Kuruc Yinyan Xu Cynthia Gay Paul M Armistead Michael Hudgens Nilu P Goonetilleke Source Type: research

Transcriptome profiling of regulatory T cells from children with Transient Hypogammaglobulinemia of Infancy
Clin Exp Immunol. 2023 Nov 4:uxad116. doi: 10.1093/cei/uxad116. Online ahead of print.ABSTRACTTransient Hypogammaglobulinemia of Infancy (THI) is one of the most common forms of hypogammaglobulinemia in the early childhood. THI is usually associated with chronic, recurrent bacterial and viral infections, life-threatening in some cases, yet its pathogenesis is still largely unknown. Since our previous findings indicated the possible role of Treg cells in the pathomechanism of THI, the aim of the current study was to investigate gene expression profile of Treg cells isolated from THI patients. The transcriptome-wide gene pro...
Source: Clinical and Developmental Immunology - November 8, 2023 Category: Allergy & Immunology Authors: Magdalena Rutkowska-Zapa ła Agnieszka Grabowska Marzena Lenart Anna Kluczewska Anna Szaflarska Krzysztof Kobylarz Anna Pituch-Noworolska Maciej Siedlar Source Type: research

Tuning the potency and selectivity of ImmTAC molecules by affinity modulation
Clin Exp Immunol. 2023 Nov 1:uxad120. doi: 10.1093/cei/uxad120. Online ahead of print.ABSTRACTT cell engaging bispecifics have great clinical potential for the treatment of cancer and infectious diseases. The binding affinity and kinetics of a bispecific molecule for both target and T cell CD3 have substantial effects on potency and specificity, but the rules governing these relationships are not fully understood. Using ImmTAC (Immune mobilizing monoclonal TCRs Against Cancer) molecules as a model, we explored the impact of altering affinity for target and CD3 on the potency and specificity of the re-directed T cell respon...
Source: Clinical and Developmental Immunology - November 6, 2023 Category: Allergy & Immunology Authors: Ian B Robertson Rachel Mulvaney Nele Dieckmann Alessio Vantellini Martina Canestraro Francesca Amicarella Ronan O'Dwyer David K Cole Stephen Harper Omer Dushek Peter Kirk Source Type: research

Diagnostic significance of blood lymphocyte activation markers in pre-eclampsia
Clin Exp Immunol. 2023 Oct 31:uxad121. doi: 10.1093/cei/uxad121. Online ahead of print.ABSTRACTThe adaptive and innate immune system is important in both initiating and preventing functional disorders during pregnancy, one of which is pre-eclampsia. The research aims to conduct the comparative quantification of selected subpopulations of peripheral blood immunoregulatory cells in pregnant women with pre-eclampsia in the third trimester. The marker receptors CD4, CD8, CD95, CD25, CD27, and the marker antigen HLA-DR were considered. The screening was performed by flow cytometry with dual phenotyping using phycoerythrin- and ...
Source: Clinical and Developmental Immunology - November 3, 2023 Category: Allergy & Immunology Authors: Almagul Kurmanova Gulfairuz Urazbayeva Aigul Terlikbayeva Damilya Salimbaeva Ardak Ayazbekov Source Type: research

Regulatory T Cells in Inflamed Liver are Dysfunctional in Murine Primary Biliary Cholangitis
In conclusion, the function of Tregs in the inflamed liver of PBC was insufficient, and low-dose IL-2 treatment could not restore their function to suppress pathological immune responses. Transferring normal Tregs or directly targeting effector CD8 T cells may be beneficial for treating PBC.PMID:37916967 | DOI:10.1093/cei/uxad117 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - November 2, 2023 Category: Allergy & Immunology Authors: Chia-I Lin Yu-Wen Wang Chih-Yu Liu Hung-Wen Chen Pi-Hui Liang Ya-Hui Chuang Source Type: research

Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis
Clin Exp Immunol. 2023 Oct 31:uxad119. doi: 10.1093/cei/uxad119. Online ahead of print.ABSTRACTPatients with decompensated liver cirrhosis, in particular those classified as Childs-Pugh class C, are at increased risk of severe COVID-19 upon infection with SARS-CoV-2. The biological mechanisms underlying this are unknown. We aimed to examine the levels of serum intrinsic antiviral proteins as well as alterations in the innate antiviral immune response in patients with decompensated liver cirrhosis. Serum from 53 SARS-CoV-2 unexposed and unvaccinated individuals, with decompensated liver cirrhosis undergoing assessment for l...
Source: Clinical and Developmental Immunology - November 2, 2023 Category: Allergy & Immunology Authors: Gordon Greville Sinead Cremen Shauna O'Neill Sarah Azarian Gareth Brady William McCormack Adam H Dyer Nollaig M Bourke Olivier Touzelet David Courtney Ultan F Power Paul Dowling Tom K Gallagher Connor G G Bamford Mark W Robinson Source Type: research

Valganciclovir modulates the TNF axis molecules expression and CD4+ T cell subsets in disseminated Kaposi Sarcoma patients
In conclusion, VGC, as an add-on therapy in DKS/HIV patients, gradually modulates the activation of CD4+ T cell subsets and the TNF/TNFRs axis, suggesting a better regulation of the inflammatory status.PMID:37904542 | DOI:10.1093/cei/uxad115 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - October 31, 2023 Category: Allergy & Immunology Authors: Lucero A Ramon-Luing Julio Flores-Gonzalez Luis Angel Garc ía-Rojas Beda Islas-Mu ñoz Patricia Volkow-Fern ández Leslie Chavez-Galan Source Type: research